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RISS 인기검색어
- 검색키워드
- 저자 : Michael C. Murphy (검색결과 3 건)
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박태현(Taehyun Park),Michael C. Murphy 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
A new concept of circulating tumor cell (CTC) capture device is developed for fast, simple, and inexpensive breast cancer diagnosis. The high flow rate CTC capture device overcomes the current limitation of the CTC capture method. Current technology could not offer high flow rate capture of CTCs or high capture purity of the target cells due to the low flow velocity or lack of specific binding. The high flow rate device manipulates velocity vectors and forces the target cells toward the antibody immobilized channel surfaces to maximize the capture rate. Non-specifically bound cells washed out during rinsing process or drained through micro channels. The remained target cells, fluorescence stained and specifically bound target cells, counted using a fluorescence microscope. The high flow rate devices were hot embossed on the Poly(methyl methacrylate) and UV modified. Anti-EpCAM was immobilized on the UV modified PMMA surface after amine functionalization process. The disposable polymer CTC capture device will increase the early stage detection rate because it increase the breast cancer exam frequency. The disposable high flow rate CTC capture device shows high capture rate (~85%) at high flow rate (0.75 ㎖/min) with high purity from 7.5 ㎖ whole blood. Viable MCF-7 cells were stained with membrane fluorescence. Exact number of MCF-7 cells were spiked in 7.5 ㎖ of undiluted blood and recovered using the high flow rate device in 10 minutes.
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SEALING OF POLYMER MICRO DEVICES USING A BOILING POINT CONTROL SYSTEM
Taehyun Park(박태현),In-Hyouk Song(송인혁),Michael C. Murphy 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
A new advanced technique for thermoplastic fusion bonding (TPB) using a Pressure-Assisted Boiling Point (PABP) control system was developed. The proposed PABP system enables precise control of both the temperature and pressure in the fusion layer. The temperature variation was ~ 0.1℃ at the target temperature and a uniform pressure distribution was accomplished. Very low aspect ratio channels (AR=1/100, 10 ㎛ in depth and 1000 ㎛ in width) were successfully sealed without deformation or collapse. Bond strengths were greater than 496 ㎪. In addition, a microfluidic system on a non-flat surface was sealed, enabling Lab-on-a-Foil technology. The PABP system can be easily built using inexpensive components and simply operated. Moreover the PABP system should be scalable for mass production and large area devices.
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Surgical revascularization for Moyamoya disease in the United States: A cost-effectiveness analysis
Wali Arvin R.,Santiago-Dieppa David. R.,Srinivas Shanmukha,Brandel Michael G.,Steinberg Jeffrey A.,Rennert Robert C,Mandeville Ross,Murphy James D.,Olson Scott,Pannell J. Scott,Khalessi Alexander A. 대한뇌혈관외과학회 2021 Journal of Cerebrovascular and Endovascular Neuros Vol.23 No.1
Objective Moyamoya disease (MMD) is a vasculopathy of the internal carotid arteries with ischemic and hemorrhagic sequelae. Surgical revascularization confers upfront peri-procedural risk and costs in exchange for long-term protective benefit against hemorrhagic disease. The authors present a cost-effectiveness analysis (CEA) of surgical versus non-surgical management of MMD. Methods A Markov Model was used to simulate a 41-year-old suffering a transient ischemic attack (TIA) secondary to MMD and now faced with operative versus nonoperative treatment options. Health utilities, costs, and outcome probabilities were obtained from the CEA registry and the published literature. The primary outcome was incremental cost-effectiveness ratio which compared the quality adjusted life years (QALYs) and costs of surgical and nonsurgical treatments. Base-case, one-way sensitivity, two-way sensitivity, and probabilistic sensitivity analyses were performed with a willingness to pay threshold of $50,000. Results The base case model yielded 3.81 QALYs with a cost of $99,500 for surgery, and 3.76 QALYs with a cost of $106,500 for nonsurgical management. One-way sensitivity analysis demonstrated the greatest sensitivity in assumptions to cost of surgery and cost of admission for hemorrhagic stroke, and probabilities of stroke with no surgery, stroke after surgery, poor surgical outcome, and death after surgery. Probabilistic sensitivity analyses demonstrated that surgical revascularization was the cost-effective strategy in over 87.4% of simulations. Conclusions Considering both direct and indirect costs and the postoperative QALY, surgery is considerably more cost-effective than non-surgical management for adults with MMD.
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