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From Romantic Historiography to Populist Folklorism:
Metin Turan Institute for Eurasian Turkic Studies Dongduk Wome 2018 The Journal of Eurasian Turkic Stidies Vol.1 No.-
Folklore studies in Turkey date back to the beginning of 20 th century, though folklore studies in the West originated almost a hundred years earlier, during the 19 th century. At this time, theoretical studies on folklore reached a significant level. The folkloric discipline remains a nascent one in Turkey, which has diversified the academic formations of those interested in the field. Initially folkloric research and interest was popularized by sociologist Ziya Gökalp, philosopher Rıza Tevfik, and historian Mehmet Fuar Köprülü and it also aroused interest of a huge mass of curious people with the popularity it evoked culturally. In particular, Community Centers that were founded in 1932 became the focal point for compiling oral and folk-culture products. Yaşar Kemal, a hugely important novelist who is cultivated in Turkish literature throughout the 20 th century, also made his mark on folkloric studies through his collation Ağıtlar which was published by Adana Community Center he joined when he started writing. Ultimately, Kemal became famous for the novels he wrote as an epic narrator of world literature. His phraseology, which was the subject of his novels, was based on his own knowledge of folklore. Kemal also told epics and sung ballads under the nickname “Kör Aşık”. Key words: Folklore, epic novel, epic, Turkish literature, Yaşar Kemal.
Mostafakamal Shams,Ertan Yildirim,Melek Ekinci,Metin Turan,Atilla Dursun,Fazilet Parlakova,Raziye Kul 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.3
We investigated the effects of exogenous glycine betaine (GB) applications on antioxidant enzyme activity, dry matter, and the contents of organic acids, amino acids, total antioxidants, and total phenolics in lettuce, Lactuca sativa, under salt stress. The treatments included four concentrations of GB (0, 5, 10, and 25 mM) and two levels of salinity (0 and 100 mM of NaCl). The 25 mM GB treatment increased dry matter and the content of total phenolics in lettuce plants compared to the non-GB-treated plants under salt stress. Salinity (100 mM NaCl without GB) significantly reduced dry matter, total phenolic content, and total antioxidant content in the plants. However, the lettuce plants grown under salt stress generally had higher amino acid and organic acid contents than those grown under non-salinity conditions. GB treatments had different effect on amino acid and organic acid contents under salinity conditions. Superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX) activities were elevated under the 100 mM NaCl and 0 mM GB treatments, whereas higher concentrations of GB decreased them under salt stress. The 25 mM GB treatment mitigated the negative effect of salt stress and increased the dry matter by 44% compared to the plants that were treated with 100 mM NaCl and 0 mM GB. The results suggested that exogenous GB treatments could ameliorate the tolerance of lettuce to salt stress by increasing the total antioxidants and total phenolics, and regulating antioxidant enzyme activity, and altering the contents of organic acids and amino acids.
Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo
Saraydin, Serpil Unver,Tuncer, Ersin,Tepe, Bektas,Karadayi, Sule,Ozer, Hatice,Sen, Metin,Karadayi, Kursat,Inan, Deniz,Elagoz, Sahande,Polat, Zubeyde,Duman, Mustafa,Turan, Mustafa Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Background: There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. Here we investigated the antiproliferative properties of Melissa officinalis (MO) from Turkey on breast cancer. Methods: MO extracts were studied for cytotoxicity against breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231). In vitro apoptosis studies were performed by annexin V staining and flow cytometry analyses. Immunohistochemistry for Ki-67 and caspase 7 in the tumoral tissue sections of DMBA-induced mammary tumors in rats was also performed, along with TUNEL assays to detect apoptotic cells. In vivo anticancer activity testing was carried out with reference to inhibition of growth of DMBA induced mammary tumors in rats. Results: MO showed cytotoxicity against three cancer cell lines, inducing increase in Annexin-positive cells. Expression of caspase-7 protein and TUNEL positive cells were much higher in rats treated by MO, compared with the untreated control group, while expression of Ki-67 was decreased. Furthermore, in vivo studies showed that mean tumor volume inhibition ratio in MO treated group was 40% compared with the untreated rats. Conclusion: These results indicated that MO extrcts have antitumoral potential against breast cancer.
Cyclin D1 Gene G870A Variants and Primary Brain Tumors
Zeybek, Umit,Yaylim, Ilhan,Ozkan, Nazli Ezgi,Korkmaz, Gurbet,Turan, Saime,Kafadar, Didem,Cacina, Canan,Kafadar, Ali Metin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Alterations of cyclin D1, one of the main regulators of the cell cycle, are known to be involved in various cancers. The CCDN1 G870A polymorphism causes production of a truncated variant with a shorter half-life and thus thought to impact the regulatory effect of CCDN1. The aim of the present study was to contribute to existing results to help to determine the prognostic value of this specific gene variant and evaluate the role of CCDN1 G870A polymorphism in brain cancer susceptibility. A Turkish study group including 99 patients with primary brain tumors and 155 healthy controls were examined. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. The CCDN1 genotype frequencies in meningioma, glioma and control cases were not significantly different (p>0.05). No significant association was detected according to clinical parameters or tumor characteristics; however, a higher frequency of AG genotype was recorded within patients with astrocytic or oligoastrocytic tumors. A significant association between AG genotype and gliobilastoma multiforme (GBM) was recorded within the patients with glial tumors (p value=0.048 OR: 1.87 CI% 1.010-3.463). According to tumor characteristics, no statistically significant difference was detected within astrocytic, oligoasltrocytic tumors and oligodentrioglias. However, patients with astrocytic astrocytic or oligoastrocytic tumors showed a higher frequency of AG genotype (50%) when compared to those with oligodendrioglial tumors (27.3%). Our results indicate a possible relation between GBM formation and CCDN1 genotype.