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- 저자 : Merhi, Zaher (검색결과 2 건)
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Merhi, Zaher,Seckin, Serin,Mouanness, Marco The Korean Society for Reproductive Medicine 2022 Clinical and Experimental Reproductive Medicine Vol.49 No.3
Objective: Platelet-rich plasma (PRP) therapy has received a considerable attention as an adjunct to fertility treatments, especially in women with very low ovarian reserve and premature ovarian insufficiency. Although recent studies have demonstrated that PRP led to improvements in folliculogenesis and biomarkers of ovarian reserve, the effect of intraovarian PRP administration on embryo genetics has not been studied. Methods: We report a pilot study of patients who had preimplantation genetic testing for aneuploidy (PGT-A) before and then within 3 months following PRP administration. Twelve infertile women with at least one prior failed in vitro fertilization (IVF) cycle underwent ovarian stimulation (cycle 1) with a gentle stimulation protocol and PGT-A performed at the blastocyst stage. Following cycle 1, autologous intraovarian PRP administration was performed. Within 3 months following PRP administration, the patients underwent cycle 2 and produced blastocysts for PGT-A. The percentage of euploid embryos between both cycles was compared. Results: The mean age of all participants was 40.08±1.46 years, and their mean body mass index was 26.18±1.18 kg/m<sup>2</sup>. The number of good-quality embryos formed at the blastocyst stage was similar between cycle 1 and cycle 2 (3.08±0.88 vs. 2.17±0.49, respectively; p=0.11). Among all patients in cycle 1, 3 of 37 embryos were euploid (8.11%) while in cycle 2, 11 out of 28 embryos were euploid (39.28%, p=0.002). Three clinical pregnancies were noted among this patient group. Conclusion: This novel study is the first to present an improvement in the embryo euploidy rate following intraovarian PRP application in infertile women with prior failed IVF cycles. The growth factors present in PRP may exhibit a local paracrine effect that could improve meiotic aberrations in human oocytes and thus improve euploidy rates. Whether PRP improves live birth rates and lowers miscarriage rates remains to be determined in large trials.
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Ali Merhi,Chris W. Letchford 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.5
The concept of Performance objective assessment is extended to wind engineering. This approach applies using the Database-Assisted Design technique, relying on the aerodynamic database provided by the National Institute of Standards and Technology (NIST). A structural model of a low-rise building is analyzed to obtain influence coefficients for internal forces and displacements. Combining these coefficients with time histories of pressure coefficients on the envelope produces time histories of load effects on the structure, for example knee and ridge bending moments, and eave lateral drift. The peak values of such effects are represented by an extreme-value Type I Distribution, which allows the estimation of the gust wind speed leading to the mean hourly extreme loading that cause specific performance objective compromises. Firstly a fully correlated wind field over large tributary areas is assumed and then relaxed to utilize the denser pressure tap data available but with considerably more computational effort. The performance objectives are determined in accordance with the limit state load combinations given in the ASCE 7-16 provisions, particularly the Load and Resistance Factor Design (LRFD) method. The procedure is then repeated for several wind directions and different dominant opening scenarios to determine the cases that produce performance objective criteria. Comparisons with two approaches in ASCE 7 are made.
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