Natural and Synthetic Flavonoids: Structure–Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia

Menezes, José,C. J. M. D. S.,Orlikova, Barbora,Morceau, Franck,Diederich, Marc Taylor Francis 2016 Critical reviews in food science and nutrition Vol.56 No.-

<P>Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory, and antiviral activities. These flavonoids can also act as chemopreventive agents by their interaction with different proteins and can play a vital role in chemotherapy, suggesting a positive correlation between a lower risk of cancer and a flavonoid-rich diet. These agents interfere with the main hallmarks of cancer by various individual mechanisms, such as inhibition of cell growth and proliferation by arresting the cell cycle, induction of apoptosis and differentiation, or a combination of these mechanisms. This review is an effort to highlight the therapeutic potential of natural and synthetic flavonoids as anticancer agents in leukemia treatment with respect to the structure-activity relationship (SAR) and their molecular mechanisms. Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family.</P>

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

de Menezes, Raquel Ferreira,Bergmann, Anke,Thuler, Luiz Claudio Santos Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

This study aimed to discuss the consumption of alcohol as a risk factor for major cancers. We performed a search in the PubMed database, using the following inclusion criteria: meta-analysis published in English in the last 10 years that addressed the relationship between alcohol and the risk of developing cancer. The results indicate that moderate to heavy consumption of alcohol increases the risk of developing cancer of the oral cavity and pharynx, esophagus, stomach, larynx, colorectum, central nervous system, pancreas, breast and prostate. This review did not find any association between alcohol consumption and an increased risk of cancers of the lung, bladder, endometrium and ovary. It was also observed that alcohol consumption may be inversely related to thyroid cancer. Our systematic review has confirmed consumption of alcohol as a risk factor for the development of several types of cancer.

Effect of Cattle Manure Inoculation with an Alkaline Phytase Producing Bacilli in Organic P M ineralization, Bacterial Community and Wheat P Uptake

Daniel Menezes-Blackburn,Milko Jorquera,Nitza Inostroza,Ralf Greiner,Jacquelinne Acuna,Maria De La Luz Mora 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test

Liliane Menezes Fernandes,Zaira da Rosa Guterres,Igor Vivian Almeida,Veronica Elisa Pimenta Vicentini 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.6

Vitexin is a C-glycosylated flavone found in various medicinal plants with several proven biological properties such as anti-inflammatory, antispasmodic, antimicrobial, cytotoxic, and antioxidant activities. Considering that the human population consumes many foods that contain this flavonoid, the objective of this study was to investigate the genotoxic and the antigenotoxic potentials of vitexin by the SMART (Somatic Mutation and Recombination Test) in Drosophila melanogaster wings, in vivo. To evaluate the genotoxic activity, larvae obtained from standard (ST) and high bioactivation (HB) crosses were chronically treated with different concentrations of vitexin (0.15, 0.3, and 0.6 mM). For the evaluation of antigenotoxic activity, the same vitexin concentrations were associated with two damage inducing agents: doxorubicin (0.2 mM) and benzo[a]pyrene (1.0 mM). The results obtained for genotoxic activity showed that vitexin did not induce a statistically significant increment in the frequency of mutant spots, when compared to control. The results for the evaluation of antigenotoxicity indicated that the flavonoid statistically reduced the frequency of mutant spots, when compared to those treated with only the damage inducing agents. Thus, this article presents results that have demonstrated the antigenotoxic activity of vitexin, which could be applied in new studies for the development of drugs with chemoprotective effects.

Leadership, Interaction Process, and Effectiveness : Short and Long-Run Behaviour of the COD Value Chain Between Norway and Portugal: A Case Study

( Rui Menezes ),( Joao Ferreira Dias ) 한국행정학회 2003 Bulletins et mémoires de la Societe d'Anthropologi Vol.2003 No.-

Masquerade as Memory: Conflict as Heritage in Lavras do Abade, Brazil

Diogo Menezes Costa 국립민속박물관 2016 International Journal of Intangible Heritage Vol.11 No.-

This article presents a discussion about the memory of an environmental conflict that occurred in the mining village of Lavras do Abade in mid-western Brazil at the end of the nineteenth century. I introduce a study of the phenomenon called Mascarados, part of the religious festival of the present-day town, and its relationship to the previous conflict in the neighbourhood. I report several interviews I conducted about this historical disagreement with the oldest residents in the present-day town of Pirenópolis, an old rival village formerly called Meia Ponte. Finally, I discuss theories about the individual and group implications of this ‘masked memory’ and its impact on the community's archaeological, historical and environmental heritage.

Reconstruction of genome-scale metabolic models of non-conventional yeasts: current state, challenges, and perspectives

Eduardo Luís Menezes de Almeida,Eduard J. Kerkhoven,Wendel Batista da Silveira 한국생물공학회 2024 Biotechnology and Bioprocess Engineering Vol.29 No.1

Non-conventional yeasts are promising cell factories to produce lipids and oleochemicals, metabolites of industrial interest ( e.g ., organics acids, esters, and alcohols), and enzymes. They can also use diff erent agro-industrial by-products as substrates within the context of a circular economy. Some of these yeasts can also comprise economic and health burdens as pathogens. Genome-scale metabolic models (GEMs), networks reconstructed based on the genomic and metabolic information of one or more organisms, are great tools to understand metabolic functions and landscapes, as well as propose engineering targets to improve metabolite production or propose novel drug targets. Previous reviews on yeast GEMs have mainly focused on the history and the evaluation of Saccharomyces cerevisiae modeling paradigms or the accessibility and usability of yeast GEMs. However, they did not describe the reconstruction strategies, limitations, validations, challenges, and research gaps of non-conventional yeast GEMs. Herein, we focused on the reconstruction of available non- Saccharomyces GEMs, their validation, underscoring the physiological insights, as well as the identifi cation of both metabolic engineering and drug targets. We also discuss the challenges and knowledge gaps and propose strategies to boost their use and novel reconstructions.

Water requirement and crop coefficient of sugarcane cultivated in Nicaragua

Pereira Rafael Menezes,Schwerz Felipe,Diotto Adriano Valentim,Sandoval Marlon Daniel Vargas,Aguirre Milton Javier Alvarado 한국작물학회 2024 Journal of crop science and biotechnology Vol.27 No.1

Sugarcane is one of the main agro-industrial crops in Nicaragua and Central America and one of the crops with the highest evapotranspiration rates. The lack of information related to sugarcane evapotranspiration as well as the crop coefficient (Kc) has limited productivity and water resources in Nicaragua. The knowledge of crop coefficient and water requirement for sugarcane, developed locally, will guide companies, farmers, and technicians for better irrigation management. In this context, this study aimed to determine the crop evapotranspiration and Kc for sugarcane in Nicaragua and to compare the results with those suggested by FAO. The study was performed in a field experiment at the Casur Sugarcane mill in Nicaragua, where the sugarcane was cultivated in a vertisol with a furrow irrigation method. The reference evapotranspiration was estimated using the Penman–Monteith FAO approach, and the crop evapotranspiration (ETc) was determined using the field water balance method. During the crop season, the total ETc was 1346.6 mm, resulting in a 0.90 average of Kc. The determined Kc for initial, tillering, grand growth and maturity was 0.37, 0.91, 1.11, and 0.71, respectively. The Kc proposed by FAO showed values 11.11% higher than that obtained in this study. These results highlight the importance of determining the Kc values at a local scale, parameters that guide irrigation management to use the water resources efficiently.

Adhesive systems applied to dentin substrate under electric current; systematic review

Maciel Carolina Menezes,Souto Tatiane Cristina Vieira,Pinto Bárbara de Almeida,Silva-Concilio Laís Regiane,Baroudi Kusai,Vitti Rafael Pino 대한치과보존학회 2021 Restorative Dentistry & Endodontics Vol.46 No.4

Objectives The purpose of this systematic review was to collect and discuss the technique of adhesive systems application on dentin substrate under electric current. Materials and Methods The first search strategy was based on data available at PubMed, LILACS, Scielo, Scopus, and Cochrane Library, using a combination of descriptors such as “dentin bond agents OR adhesive system AND electric current OR electrobond” or “dentin bonding agents OR dentin bonding agent application OR adhesive system AND electric current OR electrobond”, with no limit regarding the publication year. The second search strategy was based on the articles' references found previously. An additional search strategy was applied that concerned the proposed theme in the SBU-UNICAMP (Unicamp's Library System Institutional Repository). Results Twelve studies published between 2006 and 2020 were found. The analyses of the selected studies showed that the use of electric current during adhesive systems application on dentin, whether conventional or self-conditioning, increases resinous monomer infiltration in the dentin substrate, which improves the hybridization processes and the bond strength of the restorative material to dentin. Conclusions Despite the favorable results related to the use of this technique, there is still no specific protocol for the application of adhesive systems under electric current. Objectives The purpose of this systematic review was to collect and discuss the technique of adhesive systems application on dentin substrate under electric current. Materials and Methods The first search strategy was based on data available at PubMed, LILACS, Scielo, Scopus, and Cochrane Library, using a combination of descriptors such as “dentin bond agents OR adhesive system AND electric current OR electrobond” or “dentin bonding agents OR dentin bonding agent application OR adhesive system AND electric current OR electrobond”, with no limit regarding the publication year. The second search strategy was based on the articles' references found previously. An additional search strategy was applied that concerned the proposed theme in the SBU-UNICAMP (Unicamp's Library System Institutional Repository). Results Twelve studies published between 2006 and 2020 were found. The analyses of the selected studies showed that the use of electric current during adhesive systems application on dentin, whether conventional or self-conditioning, increases resinous monomer infiltration in the dentin substrate, which improves the hybridization processes and the bond strength of the restorative material to dentin. Conclusions Despite the favorable results related to the use of this technique, there is still no specific protocol for the application of adhesive systems under electric current.

Convergence of Health Level Seven Version 2 Messages to Semantic Web Technologies for Software-Intensive Systems in Telemedicine Trauma Care

Pedro Monteiro Menezes,Timothy Wayne Cook,Luciana Tricai Cavalini 대한의료정보학회 2016 Healthcare Informatics Research Vol.22 No.1

Objectives: To present the technical background and the development of a procedure that enriches the semantics of Health Level Seven version 2 (HL7v2) messages for software-intensive systems in telemedicine trauma care. Methods: This study followed a multilevel model-driven approach for the development of semantically interoperable health information systems. The Pre-Hospital Trauma Life Support (PHTLS) ABCDE protocol was adopted as the use case. A prototype application embedded the semantics into an HL7v2 message as an eXtensible Markup Language (XML) file, which was validated against an XML schema that defines constraints on a common reference model. This message was exchanged with a second prototype application, developed on the Mirth middleware, which was also used to parse and validate both the original and the hybrid messages. Results: Both versions of the data instance (one pure XML, one embedded in the HL7v2 message) were equally validated and the RDF-based semantics recovered by the receiving side of the prototype from the shared XML schema. Conclusions: This study demonstrated the semantic enrichment of HL7v2 messages for intensive-software telemedicine systems for trauma care, by validating components of extracts generated in various computing environments. The adoption of the method proposed in this study ensures the compliance of the HL7v2 standard in Semantic Web technologies.