http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Meneghetti, Fiorella,Villa, Stefania,Masciocchi, Daniela,Barlocco, Daniela,Toma, Lucio,Han, Dong‐,Cho,Kwon, Byoung‐,Mog,Ogo, Naohisa,Asai, Akira,Legnani, Laura,Gelain, Arianna WILEY‐VCH Verlag 2015 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY Vol.2015 No.22
<P><B>Abstract</B></P><P>Three new ureido‐pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor <B>AVS‐0288</B>, were designed by taking into account the structure–activity relationships determined for several ureido‐oxadiazole derivatives previously studied by our group. Their synthesis was first attempted through suitable 5‐aminopyridazinone intermediates (<B>6a</B> and <B>6b</B>), which molecular structures were confirmed by means of X‐ray diffraction data on <B>6a</B>. Amine functionalization was unsuccessful, therefore, an alternative method was devised. Dual‐luciferase and AlphaScreen‐based assays were used to test their activity. The obtained data were rationalized on the basis of a modeling study, which focused our attention on the geometrical preferences of the ureido moiety. Computational results seem to indicate that both the 1,2,5‐oxadiazole ring and the extended <I>ZZ</I> arrangement are essential and probably act in a synergistic way to confer significant activity against STAT3.</P>
Branched Polyethylenes Fractionated in Supercritical Propane
Frédéric Pelascini,Simoni Plentz-Meneghetti,Pierre J. Lutz,Val Krukonis,Kara Williams 한국고분자학회 2010 Macromolecular Research Vol.18 No.5
A series of polyethylenes (PEs), were synthesized in the presence of a palladium catalyst containing bulky diimine ligands (VERSIPOLTM) yielding amorphous PEs. The different PE samples were characterized by Size Exclusion Chromatography (SEC) with on line light scattering, NMR, viscometry or small angle neutron scattering (SANS) techniques to assess the molar mass, molar mass distribution (MMD), radius of gyration (or hydrodynamic radius) and degree of branching. Selected PE samples were fractionated in supercritical propane by isothermal increasing the pressure profile. In most cases, PE fractions with a sharper MMD than the original PEs were obtained. The average absolute molar masses of the resulting fractions increased steadily with increasing extraction pressure. Their dilute solution properties were compared with those of unfractionated PEs. Structural analyses confirmed the homogeneity of the degree of branching within a raw PE sample.
Laura Vitória Rizzatto,Daniel Meneghetti,Marielle Di Domênico,Júlia Cadorin Facenda,Katia Raquel Weber,Pedro Henrique Corazza,Márcia Borba 대한치과보철학회 2023 The Journal of Advanced Prosthodontics Vol.15 No.3
Purpose. The study objective was to evaluate the influence of the type of resin cement on the flexural strength and load to fracture of two chairside CAD-CAM materials after aging. Materials and Methods. A polymer-infiltrated ceramic network (PICN) and a nanoceramic resin (RNC) were used to produce the specimens. Two types of dual-cure resin cements, a self-adhesive and a universal, were investigated. Bilayer specimens were produced (n = 10) and aged for 6 months in a humid environment before the biaxial flexural strength test (σf). Bonded specimens were subjected to a mechanical aging protocol (50 N, 2 Hz, 37°C water, 500,000 cycles) before the compressive load test (Lf). σf and Lf data were analyzed using two-way ANOVA and Tukey tests (α = .05). Chi-square test was used to analyze the relationship between failure mode and experimental group (α = .05). Results. The type of resin cement and the interaction between factors had no effect on the σf and Lf of the specimens, while the type of restorative material was significant. RNC had higher σf and Lf than PICN. There was a significant association among the type of cracks identified for specimens tested in Lf and the restorative material. Conclusion. The type of resin cement had no effect on the flexural strength and load to fracture of the two investigated CAD-CAM chairside materials after aging.
Carr, Robert,Fanti, Stefano,Paez, Diana,Cerci, Juliano,Gyö,rke, Tamá,s,Redondo, Francisca,Morris, Tim P.,Meneghetti, Claudio,Auewarakul, Chirayu,Nair, Reena,Gorospe, Charity,Chung, June-Key Society of Nuclear Medicine 2014 The Journal of nuclear medicine Vol.55 No.12
<P>The International Atomic Energy Agency sponsored a large, multinational, prospective study to further define PET for risk stratification of diffuse large B-cell lymphoma and to test the hypothesis that international biological diversity or diversity of healthcare systems may influence the kinetics of treatment response as assessed by interim PET (I-PET). <B>Methods:</B> Cancer centers in Brazil, Chile, Hungary, India, Italy, the Philippines, South Korea, and Thailand followed a common protocol based on treatment with R-CHOP (cyclophosphamide, hydroxyadriamycin, vincristine, prednisolone with rituximab), with I-PET after 2–3 cycles of chemotherapy and at the end of chemotherapy scored visually. <B>Results:</B> Two-year survivals for all 327 patients (median follow-up, 35 mo) were 79% (95% confidence interval [CI], 74%–83%) for event-free survival (EFS) and 86% (95% CI, 81%–89%) for overall survival (OS). Two hundred ten patients (64%) were I-PET–negative, and 117 (36%) were I-PET–positive. Two-year EFS was 90% (95% CI, 85%–93%) for I-PET–negative and 58% (95% CI, 48%–66%) for I-PET–positive, with a hazard ratio of 5.31 (95% CI, 3.29–8.56). Two-year OS was 93% (95% CI, 88%–96%) for I-PET–negative and 72% (95% CI, 63%–80%) for I-PET–positive, with a hazard ratio of 3.86 (95% CI, 2.12–7.03). On sequential monitoring, 192 of 312 (62%) patients had complete response at both I-PET and end-of-chemotherapy PET, with an EFS of 97% (95% CI, 92%–98%); 110 of these with favorable clinical indicators had an EFS of 98% (95% CI, 92%–100%). In contrast, the 107 I-PET–positive cases segregated into 2 groups: 58 (54%) achieved PET-negative complete remission at the end of chemotherapy (EFS, 86%; 95% CI, 73%–93%); 46% remained PET-positive (EFS, 35%; 95% CI, 22%–48%). Heterogeneity analysis found no significant difference between countries for outcomes stratified by I-PET. <B>Conclusion:</B> This large international cohort delivers 3 novel findings: treatment response assessed by I-PET is comparable across disparate healthcare systems, secondly a negative I-PET findings together with good clinical status identifies a group with an EFS of 98%, and thirdly a single I-PET scan does not differentiate chemoresistant lymphoma from complete response and cannot be used to guide risk-adapted therapy.</P>
Cerci, Juliano J.,Gyö,rke, Tamá,s,Fanti, Stefano,Paez, Diana,Meneghetti, José,Clá,udio,Redondo, Francisca,Celli, Monica,Auewarakul, Chirayu,Rangarajan, Venkatesh,Gujral, Sumeet,G Society of Nuclear Medicine 2014 The Journal of nuclear medicine Vol.55 No.10
<P>Bone marrow is an important extranodal site in diffuse large B-cell lymphoma (DLBCL), and marrow histology has been incorporated into the new National Comprehensive Cancer Network international prognostic index. Marrow involvement demonstrated histologically confers poor prognosis but is identified by staging PET in more cases. How information from staging PET and biopsy should be combined to optimize outcome prediction remains unclear. <B>Methods:</B> The International Atomic Energy Agency sponsored a prospective international cohort study to better define the use of PET in DLBCL. As a planned subsidiary analysis, we examined the interplay of marrow involvement identified by PET and biopsy on clinical outcomes. <B>Results:</B> Eight countries contributed 327 cases with a median follow-up of 35 mo. The 2-y outcomes of cases with no evidence of marrow involvement (<I>n</I> = 231) were 81% (95% confidence interval [CI], 76%–86%) for event-free survival (EFS) and 88% (83%–91%) for overall survival (OS); cases identified only on PET (<I>n</I> = 61), 81% (69%–89%) for EFS and 88% (77%–94%) for OS; cases indentified only on biopsy (<I>n</I> = 10), 80% (41%–95%) for EFS and 100% for OS; or cases identified by both PET and biopsy (<I>n</I> = 25), 45% (25%–64%) for EFS and 55% (32%–73%) for OS. The hazard ratios for PET-negative/biopsy-negative cases versus PET-positive/biopsy-positive cases were 2.67 (95% CI, 1.48–4.79) for EFS and 3.94 (1.93–8.06) for OS. <B>Conclusion:</B> This large study demonstrates that positive iliac crest biopsy histology only confers poor prognosis for patients who also have abnormal marrow <SUP>18</SUP>F-FDG uptake identified on the staging PET scan. Abnormal <SUP>18</SUP>F-FDG uptake in marrow, when iliac crest biopsy histology is normal, has no adverse effect on outcomes.</P>