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- 저자 : Meiying Xie (검색결과 2 건)
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Meiying Xie,Lina Zhang,Luoye Li,Minhuan Fan,Lianjie Hou 한국유전학회 2020 Genes & Genomics Vol.42 No.9
Background Intestinal epithelial cells are important for defending against pathogen infection. LPS is an endotoxin that is highly antigenic and cytotoxic produced by bacteria. LPS disrupts the intestine epithelium integrity and induced the intestinal epithelial cell infammation and apoptosis. Our previous study has predicted the function of exosome miRNAs through bioinformatics analysis, and we found that miR-339 had a potential function in cell infammation response. To our knowledge, no published paper has demonstrated the miR-339 function in protecting the intestine epithelium against bacterial infection. Objective The objective of this study is to evaluate the miR-339 function in regulating intestinal epithelial cells to defend against bacterial infection through biological experiments and bioinformatics analyses. Methods Through the miR-339 transfection experiment and TLR4 interfering experiment, we evaluated the function of miR339 and TLR4 in the process of infammatory responses and apoptosis. Through Bioinformatics analyses and dual-luciferase reporter experiment, we identifed the target gene of miR-339. Results miR-339 attenuates LPS-induced intestinal epithelial cells infammatory responses through the TLR4/NF-κB signaling pathway and inhibited LPS-induced apoptosis through the P53 signaling pathway. TLR4 is the target gene of miR-339. TLR4 reduced LPS-induced proinfammatory responses and apoptosis. Conclusions In conclusion, miR-339 protected the intestine epithelial cells from LPS-induced cell infammation and apoptosis through targeting TLR4. This study expanded our understanding of how miRNAs and genes work collaboratively in regulating intestinal epithelial cells to defend against bacterial infection.
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Highly elastic aerogel derived from spent coffee grounds as oil removal adsorbent
Yongli Chen,Weijie Cai,Meng Zhang,Meiying Xie,Fengzhi Tan,Fan Yang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.6
In the face of increasing environmental pollution, aerogels have emerged as valuable materials for potentialoil/water separation. However, many of the currently developed aerogels have unsatisfactory compressibility, high costand a single hydrophobic modification method, which limits larger-scale application. In this work, a type of aerogelwith compressible, inexpensive, and fully biodegradable features was designed via a novel zirconium chloride modificationstrategy. Typically, a series of aerogels (HCSW-1, HCSW-2, and HCSW-3) were readily prepared from a mixture ofspent coffee grounds, waste paper and sodium alginate. The prepared aerogels exhibited good elasticity, low density(0.024 g cm3), high porosity (98.3%), efficient oil/water separation and good oil uptake (23-44 times of its weight). Inaddition, the as-prepared aerogels can be easily recycled several times, thus meeting the demand of actual oil/waterseparation. Such prominent results provide a new perspective for the development of efficient hydrophobic aerogels inthe treatment of offshore oil spills and industrial wastewater.
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