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- 검색키워드
- 저자 : Mehnaz Kamal (검색결과 4 건)
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Mehnaz Kamal,Mamuna Naz,Talha Jawaid,Muhammad Arif 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
Free radicals are the byproducts of physiological aerobic cellular metabolism. Intrinsic antioxidant system plays its pivotal function in prevention of any loss due to free radicals. Though, incorporation or excess production of free radicals from environment to living system or imbalanced defense mechanism of antioxidant system leads to severe consequences like neuro-degeneration. Sensory or functional loss occurs in neural cells in neurodegenerative diseases. Besides numerous other genetic or environmental factors, oxidative stress is the major cause which leads to damage of neurons and production of neurodegenative diseases. However, oxygen is vital for existence, excessive reactive oxygen species production and imbalanced metabolism leads to a variety of diseases such as aging, Parkinson’s disease, Alzheimer’s disease, and many other neurodegenative diseases. Free radicals toxicity contributes to DNA and proteins damage, tissue damage, infammation and consequent cellular apoptosis. Neuroprotection is a broad term commonly used to refer therapeutic strategies that can prevent, delay or even reverse neuronal damage. Since thousands of years, lots of medicinal plants have been used in a group of herbal preparations of Ayurveda (Indian traditional health care system) named Rasayana because of the antioxidant principles present in it, responsible for their medicinal use in neurodegenerative diseases. This work constitutes a literature review on natural products contain antioxidant principles used in the treatment of neurodegenerative disease.
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Mehnaz Kamal,Muhammad Arif,Talha Jawaid 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.1
In chemotherapy for tuberculosis, leprosy, cancer and stress conditions the immune system are impaired and suppressed. In such situations the effect of adaptogenic phytoconstituents are essential for healthy blood to support optimal oxygen carrying capacity which is important for stamina. The aim of this review is to bring together most of the available scientific research related to adaptogens, those are plant-derived biologically active substances. Adaptogens are the substances that appear to induce a state of non-specific increase of resistance of the organism to diverse assaults that threaten internal homeostasis and improve physical endurance. Supplementation with various plant materials which are the source of vitamins, acids, minerals and other phytoconstituents has been evaluated for their adaptogenic activity during exposure to a stressful environment. This review has been compiled using references from major databases such as Chemical Abstracts, Science Direct, Medicinal and Aromatic Plants Abstracts, SciFinder, PubMed, Dr. Duke′s Phytochemical and Ethnobotanical Databases. Nature is a rich source of biological and chemical diversity and a number of plants in the world have been used in traditional medicine remedies. This work constitutes a literature review on medicinal plants with its chemical constituents showing adaptogenic properties. Various medicinal plants with its phytochemical constituentsareshowing adaptogenic properties and it is used during chemotherapy in which the immune system are impaired and suppressed.
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Classification, causes, diagnosis and treatment of male infertility: a review
Mamuna Naz,Mehnaz Kamal 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.2
Infertility refers to the biological inability of an individual to contribute to conception over the course of one year. Male infertility refers to a male’s incapability to cause pregnancy in a fertile female. Approximately 15% of couples are affected by infertility and among them 40–50% cases are attributed to male infertility. Male infertility is mainly categorized into Azoospermia (AS) and Coital infertility (CI). Many studies have supported that different factors such as varicocele, testicular failure, endocrine dysfunction, genital tract infection, testicular disturbances, testicular cancer, hormonal disturbances, retrograde ejaculation, prolonged exposure to heat, obesity, older age, smoking, alcohol, heavy metals, pesticides, oxidative stress, genetic factors and different environmental and nutritional factors reversibly or irreversibly influence male fertility. Male infertility can be diagnosed by different tools. Diagnosing male infertility problems usually involves physical examination, semen analysis, hormone tests, testicular biopsy, urine test etc. There are different pharmacological, non-pharmacological, combination and ethno-pharmacological treatment options for male infertility. The infertility of known etiology has considerable treatment success rate. However, genetic or idiopathic male infertility has optimized and empirical approach. This review summarizes classification, causes, diagnosis and treatment of male infertility. The article is based on English peer-reviewed articles located on Scopus, Pubmed, ScienceDirect etc.
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Talha Jawaid,Mehnaz Kamal,Richa Singh,Deepa Shukla,Vidya Devanathadesikan,Mukty Sinha 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.3
The aim of this study was to investigate the anticonvulsant and neuroprotective eff ects of methanolic extract of Cinnamomum camphora leaves (MECC) in albino wistar rats against maximal electroshock seizure (MES) and seizures induced by pentylenetetrazol (PTZ) models. Acetylcholinesterase (AChE) activity and oxidative stress parameters like malondialdehyde (MDA) and reduced glutathione (GSH) were estimated in the brains after completion of the anticonvulsant studies. MECC (50 and 100 mg/kg b.w., p.o. ) exhibited anticonvulsant activity as indicated by signifi cant ( P < 0.05, P < 0.01) reduction in the duration of hind limb tonic extensor phase in MES induced seizure model and signifi cantly ( P < 0.05, P < 0.01) increased the time of onset of clonic convulsion, decreased the duration of seizures, increased the % protection and decreased the percent mortality in a dose dependent manner. MECC (50 and 100 mg/kg b.w., p.o. ) exhibited neuroprotective activity as indicated by signifi cant reduction in MDA levels, AChE activity and increased GSH level also in a dose dependent manner. These results indicate that MECC may exert anticonvulsant and neuroprotective eff ects which may be attributed to the increase in the level of GABA, inhibition of AChE and infl ammation and antioxidant activity in the brain.
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