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        Fulminant Subacute Sclerosing Panencephalitis Presenting with Acute Ataxia and Hemiparesis in a 15-Year-Old Boy

        Rukmini Mridula Kandadai,Praveen Yada,Megha S. Uppin,Shaik Afshan Jabeen,Ajith Cherian,Meena Angamuthu Kanikannan,Rupam Borgohain,Sundaram Challa 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4

        Background Subacute sclerosing panencephalitis (SSPE) is a delayed and fatal manifestationof measles infection. Fulminant SSPE is a rare presentation in which the disease progresses todeath over a period of 6 months. The clinical features are atypical and can be misleading. Case Report We report herein a teenage boy who presented with acute-onset gait ataxia followed by right hemiparesis that evolved over 1 month, with left-hemispheric, delta-range slowing on the electroencephalogram (EEG). Magnetic resonance imaging disclosed multiple whitematter hyperintensities, suggesting a diagnosis of acute disseminated encephalomyelitis. Hereceived intravenous steroids, and within 4 days of hospital admission he developed unilateralslow myoclonic jerks. Repeat EEG revealed Rademecker complexes, pathognomonic of SSPE,and an elevated titer of IgG antimeasles antibodies was detected in his cerebrospinal fluid. Thedisease progressed rapidly and the patient succumbed within 15 days of hospitalization. The diagnosis of SSPE was confirmed by autopsy. Conclusions This case illustrates the difficulty of recognizing fulminant SSPE when it manifests with asymmetric clinical and EEG abnormalities.

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        Primary Hepatic Choriocarcinoma with Pregnancy: A Diagnostic and Therapeutic Challenge

        Amith Kumar Pakkala,Phani Kumar Nekarakanti,Bheerappa Nagari,Ashish Kumar Bansal,Gourang Shroff,Megha S Uppin 대한소화기학회 2023 대한소화기학회지 Vol.81 No.2

        Choriocarcinoma occurs mainly in the gonads, but an extragonadal origin has been reported, albeit infrequently. Primary hepatic choriocarcinoma (PHC) is a rare malignancy, with only 11 cases reported. Most cases reported were in males, with none reported in pregnant females. A 23-year-old primigravida presented with a large liver lesion involving the right lobe of the liver at 28 weeks of pregnancy. Preoperative imaging was suggestive of hepatocellular carcinoma. She underwent a non-anatomical resection of the liver lesion. Surprisingly, her postoperative histopathology revealed a diagnosis of PHC. Her blood workup showed elevated beta human chorionic gonadotrophin. She underwent a termination of her pregnancy at 32 weeks. Before initiating adjuvant chemotherapy four weeks after surgery, a whole-body PET scan revealed multiple bi-lobar liver and pelvic deposits. After a multidisciplinary team discussion, she was started on adjuvant chemotherapy. She is currently under regular follow-up, seven months post-surgery. PHC, one of the vascular lesions of the liver, poses a diagnostic and therapeutic challenge, warranting a multidisciplinary approach.

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