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- 저자 : Md. Towhidul Islam (검색결과 1 건)
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Antidiarrheal activities of hydroalcoholic extract of Sida cordifolia roots in Wister albino rats
Md. Shahed-Al-Mahmud,Tajdika Jahan,Md. Towhidul Islam 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.1
Sida cordifolia Linn. (Malvaceae) traditionally used for the treatment of chronic dysentery, diarrhea, and dyspepsia. The core aim of the present study is to evaluate the antidiarrheal activity of hydroalcoholic extract of roots of Sida cordifolia (HESC) in animal models. The antidiarrheal activity was evaluated using castor oil-induced diarrhea and magnesium sulphate-induced diarrhea models whereas Anti-secretory and anti-motility activities were investigated using castor oil-induced enteropooling assay and gastrointestinal transit test examined in animal models respectively. Antidiarrheal activities compared to loperamide, a positive control. The acute toxicity effect of the hydroalcoholic extract of S. cordifolia also investigated. S. cordifolia (100-400mg/kg) produced dose-dependent and significant protection of rats against castor oil-induced diarrhea, magnesium sulphate-induced diarrhea, delayed gastric emptying and inhibited intestinal transit. HESC, dose-dependently and significantly delayed the onset of castor-oil induced diarrhea and magnesium sulphate-induced diarrhea, decreased the frequency of defecation, and reduced the severity of diarrhea in the rats as well as loperamide (5mg/kg). Furthermore, HESC produced dose-dependent and significant anti-motility effect, caused inhibition of castor-oil-induced enteropooling in rats, almost similar to loperamide. Additionally, castor oil-induced enteropooling assay, HESC dose-dependently and significantly decreased the volume of castor oil-induced intestinal fluid secretion compared with the control group. In gastrointestinal transit test, delayed gastric emptying and decreased the propulsion of charcoal meal through the gastrointestinal tract also observed. The effect of HESC significant and dose-dependent when compared with the control group. There was no deaths or abnormalities in behavior seen in the acute toxicity test. The experimental findings indicate that HESC possesses antidiarrheal property in rats. These activities confirm the ethnomedicinal use of S. cordifolia roots a valuable natural remedy for the treatment, management, and control of diarrhea.
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