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- 저자 : Md. Monir Hossain (검색결과 2 건)
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A. F. M. Mahmudul Islam,Md. Farhan Khalik,Nizam Uddin,Md. Sazzad Hossain,Md. Monir Hossain,Md. Mahadi Hasan,S. M. Fahad,Pijus Saha 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.2
The aim of this study was to scrutinize thephysicochemical and qualitative microbial examination of 30 different (of various dosage forms) herbal medicinalproducts marketed by pharmaceutical and herbal manufacturersin Bangladesh. The microbial evaluation includedtotal viable aerobic bacteria, Escherichia coli, fungi andStaphylococcus aureus count; physicochemical propertieslike weight variation, hardness, disintegration time, friabilityand density. The IMViC (indole, methyl red, Voges–Proskauer and citrate utilization) tests were frequentlyemployed for identification of E. coli and S. aureus. Totalviable aerobic bacterial counts in the samples analyzed wereranged from 3.8 × 10⁴ to 3.2 × 108 CFU/ml or CFU/g and 36.67 % were within BP standard limit. S. aureus wasdetected in 53.33 % (16) of the samples, ranged from anestimated 3 × 10² to 9.2 × 106 CFU/ml or CFU/g whichwere above the USP standard. E. coli was detected in 40 %(12) of the samples, ranging from 1 × 10² to 4.8 × 10⁴CFU/ml or CFU/g that were above the USP standard. Theranges of the fungi counts were 3.4 × 10³ – 3.1 × 106 CFU/ml or CFU/g and 46.67 %of which were within BP standard. Physicochemical properties of herbal products manufacturedby pharmaceutical manufacturers were found betterthan that of the herbal manufacturers. From the label andpack insert of herbal products, definite release patterninformation weren’t obtained and the majority of herbalproducts showed scattered disintegration time. In order toreduce the potential health related complications, there isnecessity of constant monitoring and control of the standardsof herbal medicine products available in the Bangladeshimarket.
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Md. Rakib Hasan,Nizam Uddin,Tanmoy Sana,Md. Monir Hossain,Milon Mondal,Ismat Jarin Kanta,M. S. K. Choudhuri 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
The aim of our current study is to investigate the analgesic and anti-inflammatory potentials of methanolic extract of Mallotus repandus stem (MSM) using different in vivo assay models. Analgesic and anti-inflammatory activities were evaluated using acetic acid induced writhing test, tail immersion method, hot-plate test, formalin induced hind paw licking, xylene induced ear edema, carrageenan-induced paw edema and cotton pellet induced granuloma in animal model at doses of 500, 1000 and 2000 mg/kg body weight. MSM showed significant (p < 0.05) analgesic activities in the acetic acid-induced writhing tests in mice. In the tail immersion and hot-plate test, MSM significantly prolonged the latency period (p < 0.05). Significant (p < 0.05) formalin induced paw licking inhibition was observed at different doses and the highest 74.47% inhibition was observed at 2000 mg/kg. Besides, MSM showed significant (p < 0.05) anti-inflammatory responses in carrageenan induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. These findings suggest that the plant may be a potential source for the development of new analgesic and anti-inflammatory agent.
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