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RISS 인기검색어
- 검색키워드
- 저자 : Md. Imtaiyaz Hassan (검색결과 5 건)
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QSAR based therapeutic management of M. tuberculosis
Shahzaib Ahamad,사피쿠르라만,Faez Iqbal Khan,Neeraja Dwivedi,Sher Ali,김지회,Md. Imtaiyaz Hassan 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.6
Mycobacterium tuberculosis is responsible forsevere mortality and morbidity worldwide but, under-developedand developing countries are more prone toinfection. In search of effective and wide-spectrum antitubercularagents, interdisciplinary approaches are beingexplored. Of the several approaches used, computer basedquantitative structure activity relationship (QSAR) havegained momentum. Structure-based drug design and discoveryimplies a combined knowledge of accurate predictionof ligand poses with the good prediction andinterpretation of statistically validated models derived fromthe 3D-QSAR approach. The validated models are generallyused to screen a small combinatorial library ofpotential synthetic candidates to identify hits which furthersubjected to docking to filter out compounds as novelpotential emerging drug molecules to address multidrugresistanttuberculosis. Several newer models are integratedto QSAR methods which include different types of chemicaland biological data, and simultaneous prediction ofpharmacological activities including toxicities and/or othersafety profiles to get new compounds with desired activity. In the process, several newer molecules have been identifiedwhich are now being assessed for their clinical efficacy. Present review deals with the advances made in thefield highlighting overall future prospects of the developmentof anti-tuberculosis drugs.
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Ahmad Abu Turab Naqvi,Farah Anjum,Faez Iqbal Khan,Asimul Islam,Faizan Ahmad,Md. Imtaiyaz Hassan 한국유전체학회 2016 Genomics & informatics Vol.14 No.3
Helicobacter pylori is a Gram-negative bacteria that is responsible for gastritis in human. Its spiral flagellated body helps in locomotion and colonization in the host environment. It is capable of living in the highly acidic environment of the stomach with the help of acid adaptive genes. The genome of H. pylori 26695 strain contains 1,555 coding genes that encode 1,445 proteins. Out of these, 340 proteins are characterized as hypothetical proteins (HP). This study involves extensive analysis of the HPs using an established pipeline which comprises various bioinformatics tools and databases to find out probable functions of the HPs and identification of virulence factors. After extensive analysis of all the 340 HPs, we found that 104 HPs are showing characteristic similarities with the proteins with known functions. Thus, on the basis of such similarities, we assigned probable functions to 104 HPs with high confidence and precision. All the predicted HPs contain representative members of diverse functional classes of proteins such as enzymes, transporters, binding proteins, regulatory proteins, proteins involved in cellular processes and other proteins with miscellaneous functions. Therefore, we classified 104 HPs into aforementioned functional groups. During the virulence factors analysis of the HPs, we found 11 HPs are showing significant virulence. The identification of virulence proteins with the help their predicted functions may pave the way for drug target estimation and development of effective drug to counter the activity of that protein.
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Naqvi, Ahmad Abu Turab,Anjum, Farah,Khan, Faez Iqbal,Islam, Asimul,Ahmad, Faizan,Hassan, Md. Imtaiyaz Korea Genome Organization 2016 Genomics & informatics Vol.14 No.3
Helicobacter pylori is a Gram-negative bacteria that is responsible for gastritis in human. Its spiral flagellated body helps in locomotion and colonization in the host environment. It is capable of living in the highly acidic environment of the stomach with the help of acid adaptive genes. The genome of H. pylori 26695 strain contains 1,555 coding genes that encode 1,445 proteins. Out of these, 340 proteins are characterized as hypothetical proteins (HP). This study involves extensive analysis of the HPs using an established pipeline which comprises various bioinformatics tools and databases to find out probable functions of the HPs and identification of virulence factors. After extensive analysis of all the 340 HPs, we found that 104 HPs are showing characteristic similarities with the proteins with known functions. Thus, on the basis of such similarities, we assigned probable functions to 104 HPs with high confidence and precision. All the predicted HPs contain representative members of diverse functional classes of proteins such as enzymes, transporters, binding proteins, regulatory proteins, proteins involved in cellular processes and other proteins with miscellaneous functions. Therefore, we classified 104 HPs into aforementioned functional groups. During the virulence factors analysis of the HPs, we found 11 HPs are showing significant virulence. The identification of virulence proteins with the help their predicted functions may pave the way for drug target estimation and development of effective drug to counter the activity of that protein.
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Biomedical features and therapeutic potential of rosmarinic acid
Saba Noor,Taj Mohammad,Malik Abdul Rub,Ali Raza,Naved Azum,Dharmendra Kumar Yadav,Md Imtaiyaz Hassan,Abdullah M. Asiri 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.4
For decades, the use of secondary metabolitesof various herbs has been an attractive strategy in combatinghuman diseases. Rosmarinic acid (RA) is a bioactivephenolic compound commonly found in plants of Lamiaceaeand Boraginaceae families. RA is biosynthesizedusing amino acids tyrosine and phenylalanine via enzymecatalyzedreactions. However, the chemical synthesis of RAinvolves an esterifi cation reaction between caff eic acid and3,4-dihydroxy phenyl lactic acid contributing two phenolicrings to the structure of RA. Several studies have ascertainedmultiple therapeutic benefi ts of RA in various diseases,including cancer, diabetes, infl ammatory disorders, neurodegenerativedisorders, and liver diseases. Many previousscientifi c papers indicate that RA can be used as an antiplasmodic,anti-viral and anti-bacterial drug. In addition,due to its high anti-oxidant capacity, this natural polyphenolhas recently gained attention for its possible applicationas a nutraceutical compound in the food industry. Here we provide state-of-the-art, fl exible therapeutic potential andbiomedical features of RA, its implications and multipleuses. Along with various valuable applications in safeguardinghuman health, this review further summarizes thetherapeutic advantages of RA in various human diseases,including cancer, diabetes, neurodegenerative diseases. Furthermore,the challenges associated with the clinical applicabilityof RA have also been discussed.
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