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Biomedical features and therapeutic potential of rosmarinic acid
Saba Noor,Taj Mohammad,Malik Abdul Rub,Ali Raza,Naved Azum,Dharmendra Kumar Yadav,Md Imtaiyaz Hassan,Abdullah M. Asiri 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.4
For decades, the use of secondary metabolitesof various herbs has been an attractive strategy in combatinghuman diseases. Rosmarinic acid (RA) is a bioactivephenolic compound commonly found in plants of Lamiaceaeand Boraginaceae families. RA is biosynthesizedusing amino acids tyrosine and phenylalanine via enzymecatalyzedreactions. However, the chemical synthesis of RAinvolves an esterifi cation reaction between caff eic acid and3,4-dihydroxy phenyl lactic acid contributing two phenolicrings to the structure of RA. Several studies have ascertainedmultiple therapeutic benefi ts of RA in various diseases,including cancer, diabetes, infl ammatory disorders, neurodegenerativedisorders, and liver diseases. Many previousscientifi c papers indicate that RA can be used as an antiplasmodic,anti-viral and anti-bacterial drug. In addition,due to its high anti-oxidant capacity, this natural polyphenolhas recently gained attention for its possible applicationas a nutraceutical compound in the food industry. Here we provide state-of-the-art, fl exible therapeutic potential andbiomedical features of RA, its implications and multipleuses. Along with various valuable applications in safeguardinghuman health, this review further summarizes thetherapeutic advantages of RA in various human diseases,including cancer, diabetes, neurodegenerative diseases. Furthermore,the challenges associated with the clinical applicabilityof RA have also been discussed.
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