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POLITICAL LEADERSHIP IN CONTEMPORARY AMERICA: A THEORETICAL ANALYSIS
McWilliams, Wilson Carey,Bathory, Dennis The Institute for Far Eastern Studies Kyungnam Uni 1980 ASIAN PERSPECTIVE Vol.4 No.1
Leadership seems likely to be a central issue in the American persidential election of 1980. President Cater's Democratic and Rep-ublican rivals have made his supposed lack of leadership the center-piece of their criticism. Carter's leadership in the Iranian and Afghan crises, by contrast. Carter's leadership in the Iranian and Afghan crises, by contrast, is credited with his rise in the polls. This concern with leadership reflects a growing uneasiness in America. A recent poll revealed that, for the first time, most Americana. expected the future to be worse than the present. Americans are no longer disposed to trust the course of events; they do not like the road, and they want a leader to show them a better way.
Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells.
McWilliams, Ryan R,Breusegem, Sophia Y,Brodsky, Kelley F,Kim, Eunjoon,Levi, Moshe,Doctor, R Brian American Physiological Society 2005 American journal of physiology. Cell physiology Vol.289 No.4
<P>Proteins expressing postsynaptic density (PSD)-95/Drosophila disk large (Dlg)/zonula occludens-1 (ZO-1) (PDZ) domains are commonly involved in moderating receptor, channel, and transporter activities at the plasma membrane in a variety of cell types. At the apical membrane of renal proximal tubules (PT), the type IIa NaP(i) cotransporter (NaP(i)-IIa) binds specific PDZ domain proteins. Shank2E is a spliceoform of a family of PDZ proteins that is concentrated at the apical domain of liver and pancreatic epithelial cell types and is expressed in kidney. In the present study, immunoblotting of enriched plasma membrane fractions and immunohistology found Shank2E concentrated at the brush border membrane of rat PT cells. Confocal localization of Flag-Shank2E and enhanced green fluorescent protein-NaP(i)-IIa in cotransfected OK cells showed these proteins colocalized in the apical microvilli of this PT cell model. Shank2E co-immunoprecipitated with NaP(i)-IIa from rat renal cortex tissue and HA-NaP(i)-IIa coprecipitated with Flag-Shank2E in cotransfected human embryonic kidney HEK cells. Domain analysis showed that the PDZ domain of Shank2E specifically bound NaP(i)-IIa and truncation of the COOH-terminal TRL motif from NaP(i)-IIa abolished this binding, and Far Western blotting showed that the Shank2E- NaP(i)-IIa interaction occurred directly between the two proteins. NaP(i)-IIa activity is regulated by moderating its abundance in the apical membrane. High-P(i) conditions induce NaP(i)-IIa internalization and degradation. In both rat kidney PT cells and OK cells, shifting to high-P(i) conditions induced an acute internal redistribution of Shank2E and, in OK cells, a significant degree of degradation. In sum, Shank2E is concentrated in the apical domain of renal PT cells, specifically binds NaP(i)-IIa via PDZ interactions, and undergoes P(i)-induced internalization.</P>
Hwang, Byoung-Hoon,McWilliams, Michael,Son, Moon,Yang, Kyounghee Taylor Francis 2007 International geology review Vol.49 No.12
<P> Based on field relations and petrographic characteristics, alkali-feldspar granite in the Gigye area on the western side of the Yangsan fault is classified as an A-type granite. It is mainly composed of quartz, perthitic K-feldspar, and interstitial ferri-annite plus sodic amphiboles such as riebeckite and arfvedsonite, indicating crystallization under hypersolvus, anhydrous conditions. These petrographic features are the same as those of the A-type granite in the Gyeongju area on the east side of the Yangsan fault. These distinctive, pre-Eocene granites are separated by about 21.3 km, indicating Cenozoic dextral strike-slip of this amount along the Yangsan fault.</P>
Portal vein embolization prior to hepatectomy: Techniques, outcomes and novel therapeutic approaches
Matthew L. Hung,Justin P. McWilliams 소화기인터벤션의학회 2018 International journal of gastrointestinal interven Vol.7 No.1
Hepatectomy plays a pivotal role in the management of primary and secondary malignancies of the liver, and offers a curative option for the patient. Postoperative liver failure is a severe complication of liver resection, particularly for patients with underlying liver disease. Portal vein embolization (PVE) is a well-established preoperative technique that redirects blood flow to the anticipated remaining liver after resection in an effort to improve the functional hepatic reserve. PVE has improved the safety of hepatectomy and has extended surgical candidacy to patients who previously would have been ineligible for resection because of insufficient remnant liver volume. This article reviews the following aspects of PVE; indications, contra-indications, liver volumetry, approaches, embolization agents, recent outcomes data, and areas of active research including adjunctive therapies and temporary PVE.
F. B. ROMERO,J. M. MCWILLIAMS,E. A. FAZIO,F. A. IZQUIERDO 한국자동차공학회 2014 International journal of automotive technology Vol.15 No.6
This paper has been developed in the framework of the alternative beam T-junction solution previouslypropoused by the authors (Alcalá et al., 2013), with the scope of optimizing the behavior of buses and coaches upper structuresmodeled with beam type elements. The alternative beam T-junction model proposed by the authors, had a total of six elasticelements at the junction level allowing to modify the localized rigidity of any modeled T-junctions, therefore improving theirbehavior and avoiding the well known rigidity issue these elements have. A fundamental aspect behind the use of thesealternative beam models is related to the necessity of correctly estimating the rigidity values of the elastic elements for eachmodeled T-junction. In this context, we propose applying a surrogate model for the reference calculations which is based onstatistical Bayesian kriging predictors. Statistical predictions have the added value, with respect to deterministic solutions, ofproviding a quantification of uncertainty. The development of the kriging predictors has required the application of a statisticalmethodology including computer experiment design, computation of moments of inertia, graphical and ANOVA typesensitivity analysis and Monte Carlo computation of Bayesian inference. The results of the application have been a verysatisfactory trade-off between accuracy of approximation (prediction) and computational cost. The surrogate kriging modelsalso provide an useful tool for a better understanding of the input-output relationships involved in the reference computations.
Hyun-Jong Woo,Kyu-Sun Chung,Roger McWilliams,Taihyeop Lho 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.II
Accurate measurements of the ion velocity distribution function (IVDF), the ion temperature, and the ion drift velocity by laser-induced fluorescence (LIF) are only possible if the accurate laser wavelength during the wavelength scan is known, yet an absolute calibration is not easily achievable because of the non-linear characteristics of the piezo-electric actuator in a diode laser, the small mode-hop free tuning region, and uncertainty of the wavemeter. The LIF system for the Diversified Plasma Simulator (DiPS), which is a simulator for the divertor and space plasmas, is calibrated both by absolute calibration of the wavemeter and by launching diode lasers in opposite directions. In addition, the first result on the measurement of the ion temperature and the flow velocity is given.
Portal vein embolization prior to hepatectomy: Techniques, outcomes and novel therapeutic approaches
Matthew L. Hung,Justin P. McWilliams 소화기인터벤션의학회 2018 Gastrointestinal Intervention Vol.7 No.1
Hepatectomy plays a pivotal role in the management of primary and secondary malignancies of the liver, and offers a curative option for the patient. Postoperative liver failure is a severe complication of liver resection, particularly for patients with underlying liver disease. Portal vein embolization (PVE) is a well-established preoperative technique that redirects blood flow to the anticipated remaining liver after resection in an effort to improve the functional hepatic reserve. PVE has improved the safety of hepatectomy and has extended surgical candidacy to patients who previously would have been ineligible for resection because of insufficient remnant liver volume. This article reviews the following aspects of PVE; indications, contra-indications, liver volumetry, approaches, embolization agents, recent outcomes data, and areas of active research including adjunctive therapies and temporary PVE.