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- 저자 : McCall, S.K. (검색결과 19 건)
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Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics
McCall, Jordan G,Kim, Tae-il,Shin, Gunchul,Huang, Xian,Jung, Yei Hwan,Al-Hasani, Ream,Omenetto, Fiorenzo G,Bruchas, Michael R,Rogers, John A Nature Publishing Group, a division of Macmillan P 2013 Nature protocols Vol.8 No.12
The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. We describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers and their implementation in vivo for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin in vivo experimentation, can be completed in ∼3–8 weeks. Implementation of these devices allows for chronic (tested for up to 6 months) wireless optogenetic manipulation of neural circuitry in animals navigating complex natural or home-cage environments, interacting socially, and experiencing other freely moving behaviors.
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Grant McCall 세계환경사회거버넌스학회 2013 World Environment and Island Studies Vol.3 No.2
I want to explore some of the efforts that people living on small islands on this Island Earth have used to manage peace in their often remote places, distant from state government as all of us know it and very immediate in consequences. At the end of my conceptual survey, I propose that a space for peace could be created on Jeju Island, the Peace Island, and that an appropriate mechanism could be something we might call the “Jeju Peace Island Peace Bultuk” where interested parties can come to discuss in cultural calm and natural beauty their seeming diffculties. I give my reasons throughout the paper why I have selected Jeju Peace Island as a place for peace not only for its conditions today, but owing to features of its special cultural history. Looking at a map again, Jeju is quite separate from its neighbours in East Asia. Whilst being politically a part of the Republic of Korea, it is an autonomous region where constitutionally it could create special conditions that would permit it to assume a global role in peace negotiations. That crucial location in East Asia is a symbolic shift from the European Atlantic to the Asian Pacifc as the new locus of world power, culture and economy. Jeju’s location is very much in accord with Asia’s growing importance in world affairs. By establishing a World Peace Tribunal or “Bultuk” on Jeju Peace Island it would acknowledge this power shift as the reality that it is. On 27 January 2005, the Government of South Korea declared Jeju “Peace Island” laying the foundation for this proposal. A little over a year later, on 1 July 2006, the Republic of Korea advanced even further by declaring Jeju Peace Island an “Autonomous Self-Governing Province”, providing the basis for the place to assume an international and independent role in world affairs. Unlike existing European focused places of peace, Jeju is a small island with a small population, without global commercial, economic or political interests as is the case with The Netherlands, Switzerland and the USA, respectively. Apart from being an island with restful scenery and many pleasant places where such a World Peace Tribunal could be established, there are characteristics of the ancient Jeju culture that I think make it an appropriate place for the twenty-frst century experiment in world problem solutions.
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Grant McCall 세계섬학회 2016 World Environment and Island Studies Vol.6 No.2
I would extend the concept of “precariat” to islands and to nations. In the case of islands, global climate change may literally force people to evacuate their homes as the sea level rises over their shores. The loss of one’s livelihood can take many forms and come about in many ways, particularly in a globalised world where forces friendly and fierce can overwhelm without warning. But our subject here is islands: small potentially future green islands and why we must think big about small islands. As has often been said and written, our Earth is a relatively small place isolated in the vastness of intergalactic space and, as far as we know, the only place where we as humans effectively can survive. Just as people on small islands must get along to prosper, so must we humans do the same on our small island earth. Perhaps this is the nissological lesson that islands can teach us: how to survive and grow on our small green islands on our small blue planet?
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Why Jeju “World Peace” Island? 4.3
Grant McCall 세계섬학회 2021 World Environment and Island Studies Vol.11 No.2
The thought occurs that through “Korean Tolerance” Wonsan and the Jeju “Peace Port” at Gangeong village could be linked as “sister holiday places” by ferry, which sailing could include other ports to promote peace and Korean tolerance cruises featuring entertainment from all parts of the peninsula. Those Korean relatives in Japan could meet their DPRK families on Jeju and at other places on the Korean Tolerance cruise itinerary. There no doubt are many barriers to such a proposal as a peace and Korean Tolerance voyage between the DPRK and RoK, but the principle of Korean Tolerance and exchange between Wonsan and Jeju World Peace Island should be able to overcome such difficulties with good will throughout the peninsular polity.. “Korean Tolerance Peace Cruises” would serve to promote cultural exchange by using artists from all of Korea to learn from one another’s experiences, using their common language, shared culture and deep history
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Weir-McCall, Jonathan R.,Blanke, Philipp,Sellers, Stephanie L.,Ahmadi, Amir A.,Andreini, Daniele,Budoff, Matthew J.,Cademartiri, Filippo,Chinnaiyan, Kavitha,Choi, Jung Hyun,Chun, Eun Ju,Conte, Edoardo Elsevier 2018 Journal of cardiovascular computed tomography Vol.12 No.3
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The aim of the study is examine the impact of non-obstructive (<50%stenosis) left main (LM) disease on the natural history of coronary artery disease using serial coronary computed tomography angiography (CTA).</P> <P><B>Methods</B></P> <P>CTAs from the PARADIGM (Progression of atherosclerotic plaque determined by computed tomographic angiography imaging) study, a prospective multinational registry of patients who underwent serial CTA at a ≥2 year interval were analyzed. Those without evidence of CAD on their baseline scan were excluded, as were those with obstructive left main disease. Coronary artery vessels and their branches underwent quantification of: plaque volume and composition; diameter stenosis; presence of high-risk plaque.</P> <P><B>Results</B></P> <P>Of 944 (62 ± 9 years, 60% male) who had evidence of CAD at baseline, 444 (47%) had LM disease. Those with LM disease had a higher baseline plaque volume (194.8 ± 221mm3 versus 72.9 ± 84.3mm3, p < 0.001) and a higher prevalence of high-risk plaque (17.5% versus 13%, p < 0.001) than those without LM disease. On multivariable general linear model, patients with LM disease had greater annual rates of progression of total (26.5 ± 31.4mm3/yr versus 14.9 ± 20.1mm3/yr, p < 0.001) and calcified plaque volume (17 ± 24mm3/yr versus 7 ± 11mm3/yr, p < 0.001), with no difference in fibrous, fibrofatty or necrotic core plaque components.</P> <P><B>Conclusion</B></P> <P>The presence of non-obstructive LM disease is associated with greater rates of plaque progression and a higher prevalence of high-risk plaque throughout the entire coronary artery tree compared to CAD without LM involvement. Our data suggests that non-obstructive LM disease may be a marker for an aggressive phenotype of CAD that may benefit from more intensive treatment strategies.</P>
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Jeju World Peace Island Korean Peninsula Cruise: Planting the seeds of the Jeju King
Cherry Grant McCall 세계환경사회거버넌스학회 2022 World Environment and Island Studies Vol.12 No.2
The proposal in this paper outlines an idea for a Korean Peninsula focused Peace Cruise starting from Jeju World Peace Island and going up the eastern coast of the peninsula , taking in a port or two in Japan (such as Fukuoka) to accommodate potential Korean-descended passengers there and ending at Wonsan, where a grove of Jeju King Cherry (Prunus Yedoensis var. Nudiflora) trees could be planted progressively as a welcome avenue for those on the peace cruise ship. This grove of Jeju King Cherry trees will grow each time a Jeju World Peace Island Peninsula Cruise arrives. Wonsan has been a holiday place for the DPRK for some time and with the permission of that country could become a limited and controlled international destination for Peace and, perhaps, other cruise tours. There are precedents internationally for special zones to be declared for specific activities. Such places frequently become economic development zones for the host country. After successful itineraries have been shown, the Jeju World Peace Island ship could extend its cruise north to ports on the Kamchatka Peninsula and west to Chinese ports interested in the concept
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Arambula, J. F.,McCall, R.,Sidoran, K. J.,Magda, D.,Mitchell, N. A.,Bielawski, C. W.,Lynch, V. M.,Sessler, J. L.,Arumugam, K. THE ROYAL SOCIETY OF CHEMISTRY 2016 Chemical Science Vol.7 No.2
<P>Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)(2)](+) were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-linear geometry around the gold(I) centers (i.e., the C-Au-C bond angle were measured to be similar to 177 degrees and all the Au-C-carbene bonds distances were in the range of 2.00 (7)-2.03 (1) angstrom). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to the amount of ferrocene contained within the [Au(NHC)(2)](+) complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4-6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increased chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase.</P>
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