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Arambula, J. F.,McCall, R.,Sidoran, K. J.,Magda, D.,Mitchell, N. A.,Bielawski, C. W.,Lynch, V. M.,Sessler, J. L.,Arumugam, K. THE ROYAL SOCIETY OF CHEMISTRY 2016 Chemical Science Vol.7 No.2
<P>Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)(2)](+) were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-linear geometry around the gold(I) centers (i.e., the C-Au-C bond angle were measured to be similar to 177 degrees and all the Au-C-carbene bonds distances were in the range of 2.00 (7)-2.03 (1) angstrom). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to the amount of ferrocene contained within the [Au(NHC)(2)](+) complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4-6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increased chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase.</P>