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- 검색키워드
- 저자 : Masumori, Naoya (검색결과 4 건)
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Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk
Sugiyama, Yukiko,Masumori, Naoya,Fukuta, Fumimasa,Yoneta, Akihiro,Hida, Tokimasa,Yamashita, Toshiharu,Minatoya, Machiko,Nagata, Yoshie,Mori, Mitsuru,Tsuji, Hirokazu,Akaza, Hideyuki,Tsukamoto, Taiji Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: The age-adjusted incidence rate of prostate cancer (PCa) has been reported to be lower among Asians than Western populations. A traditional Japanese meal, high in soybean products or isoflavones, may be associated with a decreased risk of PCa. Equol, which is converted from daidzein by human intestinal flora, is biologically more active than any other isoflavone aglycone. Materials and Methods: We reviewed not only recent epidemiological studies on association of isoflavones with PCa risk, but also recent research on human intestinal bacteria responsible for converting daidzein into equol. Studies were systematically searched from the database published within the last 5 years of from 2008-2012. Results: Five out of 6 articles showed significant association of isoflavones with a decreased risk of PCa, and two of them consistently showed that equol-producers carry a significantly reduced risk of PCa. Furthermore, 5 human intestinal bacteria that can convert daidzein into equol were identified in the last 5 years. Conclusions: If equol can reduce risk of PCa, a possible strategy for reducing the risk of PCa may be to increase the proportion of equol-producers by changing the intestinal flora to carrying an equol-producing bacterium with dietary alteration or probiotic technology.
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Ureteral Reconstruction With Bowel Segments: Experience With Eight Patients in a Single Institute
Motoi Takeuchi,Naoya Masumori,Taiji Tsukamoto 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.11
Purpose: Although replacement of the ureter with a bowel segment is indicated for largeureteral defects, it is still a challenging technique for urologists. We present our experienceand outcome of ureteral reconstruction using bowel segments. Materials and Methods: Ureteral reconstruction with bowel segments was performedin eight patients in our institute between 1969 and 2009. We investigated the positionand length of the ureteral defect and methods of reconstruction as well as the patients’backgrounds, postoperative complications, and clinical outcomes. Results: Five patients underwent ureteral replacement with isolated ileal segmentsalone. In one patient, the ureter was reconstructed by using the Yang-Monti procedurewith the ileum. A colon segment was used in two patients who required bladder augmentationfor tuberculous contracted bladder at the same time. Metabolic acidosis occurredin three patients having a solitary kidney and the ureter had to be replaced by a relativelylong intestinal segment. Two patients who received preoperative radiation therapywere required to undergo additional operations. Long-term cancer-free survivalwas achieved in one patient who underwent ileal substitution for low-grade renal pelviccancer. Conclusions: Although ureteral replacement with a bowel segment is a challenging anduseful procedure, attention must be paid to the possibility of metabolic acidosis, whichis likely to occur in patients having a solitary kidney with renal insufficiency or in patientsrequiring a long intestinal segment for reconstruction. In addition, preoperativeradiation therapy for the pelvic organs may cause postoperative complications.
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Tetsuya Shindo,Kohei Hashimoto,Takashi Shimizu,Naoki Itoh,Naoya Masumori 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.4
Purpose: We conducted a prospective single-center study to evaluate the possibility of discontinuation of dutasteride after combination therapy with an alpha blocker for benign prostatic hyperplasia (BPH). Materials and Methods: We prospectively treated BPH patients with an alpha blocker and dutasteride (0.5 mg/d). Patients who had been treated with alpha blockers against BPH for more than 2 months were eligible, and 20 patients were included in the study. After 6 months of combination therapy, dutasteride was discontinued. Patients were followed for 12 months after cessation. Prostate volume, intraprostatic architecture determined by transrectal ultrasound, peak urinary flow rate, postvoid residual urine volume, and the serum prostate-specific antigen level were evaluated every 6 months, and the International Prostate Symptom Score and overactive bladder symptom score (OABSS) every 3 months. Patients were allowed to restart dutasteride during the follow-up period according to their desire. Results: Twelve patients (12/20, 60%) restarted the combination therapy from 6 to 12 months into the follow-up period. For patients who restarted dutasteride, the prostate volume and OABSS had increased and worsened after discontinuation, respectively. A visible transition zone with a clear border on transrectal ultrasound at baseline and regrowth of the prostate after discontinuation of dutasteride were risk factors for restarting the therapy (Mann-Whitney U test: p=0.008, p=0.017). Conclusions: Prostatic enlargement after discontinuation of dutasteride differs among patients. Rapid regrowth of the prostate leads to deterioration of storage symptoms and a tendency to restart dutasteride. Baseline intraprostatic architecture may be a predictive factor for whether the patient is a good candidate for discontinuation.
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Sugiyama, Yukiko,Nagata, Yoshie,Fukuta, Fumimasa,Takayanagi, Akio,Masumori, Naoya,Tsukamoto, Taiji,Akasaka, Hiroshi,Ohnishi, Hirofumi,Saito, Shigeyuki,Miura, Tetsuji,Moriyama, Kaoru,Tsuji, Hirokazu,Ak Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, $r_s$=0.639 and $r_s$=0.572, p<0.01, respectively). Serum concentrations of genistein, daidzein, glycitein, and equol were not significantly associated with risk of prostate cancer. Conclusions: This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients.
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