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- 저자 : Masoumeh Moslemi (검색결과 2 건)
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Masoumeh Moslemi,Marjan Mahdavi-Roshan,Farahnaz Joukar,Mohammadreza Naghipour,Fariborz Mansour-Ghanaei 한국식품영양과학회 2021 Preventive Nutrition and Food Science Vol.26 No.3
Food behavior and dietary pattern are major parameters affecting the health status of people. The objective of this study was investigation of food behaviors in people inhabited in North of Iran to find out association of the effective indices (related to salt and fried foods) with hypertension and other cardiovascular diseases (CVDs). This large cross-sectional study was conducted on 10,520 participants and their sociodemographic, medical, and food behavior information were evaluated. Association of salt intake with CVDs and stroke was studied by portfolio at risk (PAR) formula. Association of food behavior with hypertension and CVDs was surveyed by chi-square test. Differences were significant at P≤ 0.05. Analysis of medical information revealed that 43.18% and 8.18% of the participants had hypertension and CVDs, respectively; mostly in women. Significant association was observed between salt-related behaviors and hypertension in the participants. Regarding salt intake, higher PARs were calculated in women than men (2.26 vs. 1.88 for PARCVDs and 3.66 vs. 3.05 for PARstroke), and urban than rural inhabitants (4.56 vs. 3.66 for PARCVDs and 7.27 vs. 5.88 for PARstroke). No significant contribution was observed between oil-related behaviors and CVDs. The majority of participants were well-informed about appropriate preparation and consumption of fried foods but not a healthy behavior about salt intake. Considering the significant association of salt-related behaviors with hypertension, conducting educational programs by healthcare practitioners in the population is suggested.
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The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer
Sohrabi Ehsan,Moslemi Masoumeh,Rezaie Ehsan,Nafissi Nahid,Khaledi Mansoor,Afkhami Hamed,Fathi Javad,Zekri Ali 한국유전학회 2021 Genes & Genomics Vol.43 No.9
Background Breast cancer (BC) is a common malignancy with a high mortality rate. Malignant cell transformation is associated with metabolic changes. One group of proteins that are afected is the monocarboxylate transporters (MCTs-SLC16A). The MCTs comprise 14 members, and they play an important role in the growth, proliferation, and metabolism of cancer cells by transporting monocarboxylates such as lactate, pyruvate and thyroid hormones. Objective We aimed to evaluate the expression of MCT3 (SLC16A8), MCT8 (SLC16A2) and MCT9 (SLC16A9) genes in breast cancer samples, comparing to normal adjacent tissues. Methods Forty paired breast cancer tumor samples, the adjacent non-tumor and fve healthy tissues were collected. Three cancer cell lines (MCF-7, MDA-MB-231, and SKBR3) were also analyzed. The expression of SLC16A8, SLC16A2 and SLC16A9 were assessed using quantitative real-time PCR. The relationship between gene expression with the pathological features of the tumors, and the hormone receptors status of the patient’s tumors were also analyzed. Results There was a signifcantly lower expression of the MCT3 gene in tumor samples compared to adjacent normal tissue and healthy samples (p value<0.05). There was a signifcant diference in the expression of all three candidate genes between the BC tissues and normal tissues, and for the, tissues with diferent hormone receptor status and the molecular subtypes. Altered MCT8 and MCT9 gene expression was associated with a reduced survival Conclusion MCT3 expression is signifcantly downregulated in breast cancer tissue. MCT3 may represent a novel therapeutic target in breast cancer patients, or in some hormone receptor subgroups.
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