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Igawa, Satoshi,Sato, Yuichi,Ishihara, Mikiko,Kasajima, Masashi,Kusuhara, Seiichiro,Nakahara, Yoshiro,Otani, Sakiko,Fukui, Tomoya,Katagiri, Masato,Sasaki, Jiichiro,Masuda, Noriyuki Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Background: Pemetrexed monotherapy has come to be recognized as one of the standard second-line therapies for advanced non-squamous non-small cell lung cancer (NSCLC). However, there have been no reports of studies that have evaluated the efficacy of pemetrexed according to type of active EGFR mutation, i.e., an exon 19 deletion or an L858R point mutation. Materials and Methods: The records of non-squamous NSCLC patients harboring an EGFR mutation who received pemetrexed monotherapy as a second or later line of chemotherapy at Kitasato University Hospital between March 2010 and October 2015 were retrospectively reviewed, and the treatment outcomes were evaluated. Results: The overall response rate and progression-free survival time (PFS) of the 53 patients with non-squamous NSCLC were 15.1% and 2.3 months, respectively. There were significant differences between the disease control rate (37.5% vs. 76.2%) and PFS time (1.8 months vs. 3.3 months) of the exon 19 deletion group and the L858R point mutation group, and a multivariate analysis identified type of EGFR mutation as well as performance status (PS) as independent predictors of PFS. Conclusions: The clinical data obtained in this study provided a valuable rationale for considering type of EGFR mutation as well as non-squamous histology as predictors of the efficacy of pemetrexed monotherapy.
Fumihiko Ogata,Daisuke Imai,Megumu Toda,Masashi Otani,Naohito Kawasaki 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.34 No.-
Nickel hydroxide (Ni) was calcined at 270 and 400 8C (denoted Ni270 and Ni400), and the properties ofNi, Ni270, and Ni400 were investigated. In addition, the phosphate adsorption capabilities of Ni, Ni270,and Ni400 were evaluated by examination of the effects of contact time and solution pH, analysis of anadsorption isotherm, and study of desorption. The amounts of phosphate ion adsorbed by the differentsamples showed the order Ni < Ni400 < Ni270. Finally, phosphate ions adsorbed onto Ni270 could bedesorbed using sodium hydroxide, indicating that Ni270 can be used as a renewable adsorbent.
Development of a microchannel plate based beam profile monitor for a re-accelerated muon beam
Kim, Bongho,Bae, Sunghan,Choi, Hyunsuk,Choi, Seonho,Kawamura, Naritoshi,Kitamura, Ryo,Ko, Ho San,Kondo, Yasuhiro,Mibe, Tsutomu,Otani, Masashi,Razuvaev, Georgiy P.,Won, Eunil Elsevier 2018 Nuclear Instruments & Methods in Physics Research. Vol.899 No.-
<P><B>Abstract</B></P> <P>A beam profile monitor (BPM) based on a microchannel plate has been developed for muon beams with low transverse momentum for the measurement of the muon anomalous magnetic moment and electric dipole moment at high precision, with capability of diagnosing muon beams of kinetic energy range from a few keV to 4 MeV. The performance of the BPM has been evaluated using a surface muon beam at J-PARC and additionally with an ultraviolet (UV) light source. It has been confirmed that the BPM has a dynamic range from a few to 1 <SUP> 0 4 </SUP> muons per bunch without saturation. The spatial resolution of the BPM has been estimated to be less than 0.30 mm. The positron background from muon decays is an obstacle in muon beam profile monitoring and a partial discrimination of the positrons has been achieved under discrete particle conditions.</P>