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- 검색키워드
- 저자 : Mary Ann Lila (검색결과 3 건)
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A Comparative Evaluation of the Anticancer Properties of European and American Elderberry Fruits
Mary Ann Lila,Julie M. Thole,Tristan F. Burns Kraft,Lilly Ann Sueiro,Young-Hwa Kang,Joell J. Gills,Muriel Cuendet,John M. Pezzuto,David S. Seigler 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
European elderberry (Sambucus nigra), recognized in Europe for its health-promoting properties for many gen-erations, is known to contain a range of anthocyanins, flavonoids, and other polyphenolics that contribute to the high antiox-idant capacity of its berries. American elderberry (Sambucus canadensis), on the other hand, has not been cultivated, bred,and promoted as a medicinal plant like its better-characterized European counterpart. In this study, aqueous acetone extractsof the berries from these two species were fractionated and tested in a range of assays that gauge anticarcinogenic potential.Both cultivated S. nigraand wild S. canadensisfruits demonstrated significant chemopreventive potential through strong in-duction of quinone reductase and inhibition of cyclooxygenase-2, which is indicative of anti-initiation and antipromotion prop-erties, respectively. In addition, fractions of S. canadensisextract showed inhibition of ornithine decarboxylase, an enzymemarker related to the promotion stage of carcinogenesis. Analysis of active fractions using mass spectrometry and liquid chro-matography-mass spectrometry revealed, in addition to flavonoids, the presence of more lipophilic compounds such assesquiterpenes, iridoid monoterpene glycosides, and phytosterols.
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Elsa M. Janle,Mary Ann Lila,Michael Grannan,Lauren Wood,Aine Higgins,Gad G. Yousef,Randy B. Rogers,Helen Kim,George S. Jackson,Lap Ho,Connie M. Weaver 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Grape polyphenols confer potential health benefits, including prevention of neurodegenerative diseases. To determine the absorption and tissue distribution of the complex grape polyphenol mixture, 14C-labeled polyphenols were biosynthesized by grape cell suspension cultures, during co-incubation with radioisotopically labeled sucrose, and fractionated into polyphenolic subfractions. The pharmacokinetics and distribution of grape polyphenols into blood, brain, and peripheral interstitial fluid were determined by tracking the 14C label. The blood peak 14C concentration of the fractions ranged from 15 minutes to 4 hours. Absorption and tissue distribution varied greatly between fractions. Concentrations in interstitial fluid were lower than in blood. The amount of residual label in the brain at 24 hours ranged from 0.1% to 1.7% of the dose, depending on the fraction. 14C label found in the brain tissue and brain microdialysate indicated that grape polyphenols or their metabolites are able to cross the blood–brain barrier. Using 14C-labeled plant polyphenols it is possible to track the compounds or their metabolic products into any tissue and determine distribution patterns in spite of low concentrations. A central question regarding the potential role of dietary polyphenolics in neurodegenerative research is whether they are bioavailable in the brain. Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders.
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Maria Elisa Schreckinger,Jennifer Lotton,Mary Ann Lila,Elvira Gonzalez de Mejia 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
Dietary intake of berry fruits has been demonstrated to positively impact human health. Interest in exploring new and exotic types of berries has grown in recent years. This article provides botanical descriptions and reviews the chemistry, biological activities, and commercialization of berry-producing plants from South America, specifically Aristotelia chilensis, Euterpe oleracea, Malpighia emarginata, Ugni molinae, Fragaria chiloensis, Rubus glaucus, Rubus adenotrichus, and Vaccinium floribundum. These species possess a rich and diversified composition of bioactive compounds with health-promoting properties. The most significant health benefits have been attributed to phenolic compounds and vitamin C, potentially protective against cardiovascular disease and cancer. Although both traditional folk medicine and composition of these berries suggest significant health benefits, few studies to date have investigated these potentials.
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