http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Marko Herga,Aleš Gaspari9,Marko Bitenc,Andrej Pohar,Blaž Likozar 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.72 No.-
An industrial-scale stereo-selective enzymatic oxidation process for the conversion of pyrmetazole toesomeprazole was developed and optimized. Slurry-to-slurry stages are highly demanding syntheticoperations due to several deteriorating factors: competing equilibria, mass transfer limitations and longtermbio-catalytic activity. Challenging characteristics of this bio-oxidation included foaming, thickening,continuous dynamic changes in viscosity, mass transport, and bio-catalyst inactivation. By screening pH,optimization of reactant loading ratios, and modification of control, crucial production attributes ofmaterials, such as substrate particle size, were controlled and better batch-to-batch stability and scale-upwas achieved.