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RISS 인기검색어
- 검색키워드
- 저자 : Marietta Sitara (검색결과 2 건)
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Demosthenes Panagiotakos,Marietta Sitara,Christos Pitsavos,Christodoulos Stefanadis 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
In this study this traditional diet was assessed in relation to coronary heart disease risk and its economic con-sequences, in a cross-sectional study with economic analysis. From May 2001 to December 2002 we randomly enrolled 1,514adult men and 1,528 women, without any clinical evidence of cardiovascular disease. Adherence to the Mediterranean dietwas ascertained through a food-frequency questionnaire and a special diet score that incorporated the inherent characteristicsof this dietary pattern. The 10-year absolute risk for coronary heart disease was derived from the Framingham equations. Per-sons with a 10-year risk greater than 10% were considered as potential hospitalized patients. The health care cost of hospi-talization due to an event was estimated in 690A??per patient. Of the participants who were “closer” to the Mediterranean diet(i.e., above the median diet score) and of those “away” from this dietary pattern, 4.2% and 39.8%, respectively, had a 10-yearcoronary risk greater than 10% (P. .001). Moreover, participants “closer” to the Mediterranean diet had a 43% (odds ra-tio. 0.57, 95% confidence interval 0.38 to 0.86) lower likelihood of having a 10-year coronary risk greater than 10%, afteradjusting for potential confounders. Total health care cost was estimated to be 336.720A??in those who were “away” and 35.880A??in those who were closer to this diet pattern. Life-years lost due to disability was 6.8 in those who were “away” and0.9 in those “close” to this pattern. The incremental cost-effectiveness ratio was 50.989A??(i.e., the additive health care costdue to an unhealthy diet for each year lost). The implementation of the Mediterranean dietary pattern may lead to an im-provement in life expectancy, a net gain to health, and a reduction in total lifetime costs.
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Smaragdi Antonopoulou,Elizabeth Fragopoulou,Haralabos C. Karantonis,Eudokia Mitsou,Marietta Sitara,John Rementzis,Alexandros Mourelatos,Alexandros Ginis,Costas Phenekos 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
Patients with type 2 diabetes mellitus have increased risk of cardiovascular disease. Epidemiological studieshave shown a correlation between diet and incidence of coronary heart disease. The aim of the study is to determine the ef-fect of a traditional Greek Mediterranean diet on platelet aggregation induced by ADP, arachidonic acid (AA), and especiallyplatelet-activating factor (PAF) on patients with type 2 diabetes mellitus as well as on healthy volunteers. The patients wererandomized into two subgroups, A and B. The lipid extracts from traditional Greek Mediterranean-type meals were tested invitrofor their ability to reduce PAF- or thrombin-induced platelet aggregation. The meals with the most potent anti-aggre-gating activity were chosen for the diet of both subgroup A and healthy subjects and consumed for a period of 28 days, whereassubgroup B kept to their regular diet that was followed before entering the study. Platelet-rich plasma was isolated before andafter the diet, and the ability of platelets to aggregate under the aggregating factors was tested. One-month consumption ofdiet resulted in a significant reduction in PAF- and ADP-induced aggregation of platelets in both groups of healthy volun-teers (PAF and ADP, P. .05) and subgroup A (PAF, P. .001; ADP, P. .05), whereas the AA-induced aggregation wasnot affected. No effect was observed in subgroup B, which followed the standard diet. Thus the consumption of a traditionalGreek Mediterranean diet even for a short period can reduce platelet activity in patients suffering from type 2 diabetes mel-litus and in healthy subjects.
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