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RISS 인기검색어
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- 저자 : Mariano Victoria (검색결과 3 건)
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Hemostatic state of children with type 1 diabetes
Aleman Mariano Nicolás,Díaz Elba Irma,Luciardi Maria Constanza,Mariani Ana Carolina,Bazán Maria Cristina,Abregu Adela Victoria 대한소아내분비학회 2021 Annals of Pediatirc Endocrinology & Metabolism Vol.26 No.2
Purpose: Hyperglycemia is one of the factors responsible for the molecular alterations that modify hemostasis. The aim of this study was to determine the levels of circulating molecules that have a prothrombotic impact on the child and adolescent population with type 1 diabetes mellitus. Methods: There were 35 patients with type 1 diabetes mellitus (11.0±2.5 years of age and a median 3.7±2.0 years of the disease) with no vascular complications and 20 healthy controls with similar age, sex, and body mass index included in the study. The evaluated parameters were fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor antigen, and standard coagulation tests (platelet count, prothrombin time, and activated partial thromboplastin time). Glycemic control was evaluated by hemoglobin A1c and fasting blood glucose tests, and the presence of retinopathy and nephropathy was ruled out. The data obtained were analyzed by IBM SPSS Statistics ver. 20.0 and expressed as mean±standard deviation. The Pearson correlation coefficient was applied to investigate correlations between variables. Results: Diabetic patients showed significantly higher levels of fibrinogen (308±66 mg/dL vs. 246±18 mg/dL, P=0.0001), PAI-1 (41.6±12 ng/mL vs. 11.7±1.0 ng/mL, P=0.0001), and von Willebrand factor antigen (284%±55% vs. 121%±19%, P=0.0001). However, standard coagulation tests did not show differences between the 2 groups. PAI-1 was correlated with glycemia, hemoglobin A1c, fibrinogen, and von Willebrand factor antigen. Conclusion: Elevated levels of fibrinogen, PAI-1, and von Willebrand factor antigen were found in the pediatric and adolescent population with type 1 diabetes mellitus, which suggests a prothrombotic state.
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FE Model of Three-Dimensional Steel Beam-to-Column Bolted Extended End-Plate Joint
Concepción Díaz,Mariano Victoria,Osvaldo M. Querin,Pascual Martí 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.3
The rotational behaviour of three-dimensional steel end-plate connections can be studied using the fi nite element method for the following four reasons: (1) such models are inexpensive and robust; (2) they allow the understanding of local eff ects; (3) they can be used to generate extensive parametric studies; (4) current version of the component method lacks the appropriate components to predict the behaviour of minor-axis and three-dimensional joints. This work presents a full ANSYS fi nite element parametric model of a three-dimensional steel beam-to-column bolted extended end-plate joint in both axes for use to obtain their behaviour. The model allows to study four joint confi gurations (internal, external, corner, and plane) and includes: contact and sliding between diff erent elements; bolt-pretension, and geometric and material non-linearity. This model was calibrated and validated with experimental results found in the literature. The results from the fi nite element analysis were verifi ed by comparing the obtained moment–rotation curve of the joint. Three parametric studies are presented to show the versatility of the FE model. The results were compared with those obtained with the model proposed by Eurocode 3. The developed ANSYS FE model can be downloaded for free as a single ZIP compressed fi le from the Technical University of Cartagena (UPCT): http://www.upct.es/goe/publi cacio nes/FEM_3D_EEP.zip .
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