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Limonene and Its Oxyfunctionalized Compounds
Mario Roberto Marostica Junior,Glaucia Maria Pastore 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.4
Monoterpenes, in special limonene and its derivatives, are well studied in the literature due to their several properties. They are well recognized as major components of essential oils; some of them, are important industry residues, and others present some important biological activities. In this review, the biotransformation of the inexpensive limonene into flavor compounds was briefly reviewed and the main pathways for limonene biotransformation are presented. Furthermore, some important biological properties of these compounds were also considered, like bactericidal activity, induction of immune response, and role in disease prevention, with a little emphasis on some possibilities related to the mechanisms of anticancer action.
Producing Alkaline Lipase by Fusarium oxysporum Using Unconventional Medium Components
Cedenir Pereira de Quadros,Juliano Lemos Bicas,Iramaia Angelica Neri-Numa,Glaucia Maria Pastore 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.6
This study reports the use of different inducing agents (olive, soybean, and used frying oils) and culture mediums [synthetic medium (SM), whey protein, and corn steep liqueur (SL)] to optimize the production of lipase by Fusarium oxysporum. A relationship among the inoculum size, presence of a fat source, fungal growth, and lipase production was evident during the fermentation. The best results were achieved when the inoculum was grown in SM or SL and the fermentation was developed in SM with frying oil as the inducing agent. The maximum activity (about 15 U/㎖) was obtained after a 72 hr cultivation.
Diego Santos-García,Teresa de Deus Fonticoba,Carlos Cores Bartolomé,Maria J. Feal Painceiras,Jose M. Paz González,Cristina Martínez Miró,Silvia Jesús,Miquel Aguilar,Pau Pastor,Lluís Planellas,Marina C 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.4
Background and Purpose Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC). Methods Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81. Results At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p=0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval= 1.36–10.17, p=0.011). Conclusions VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.