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Stefano Grigolato,Stefano Panizza,Marco Pellegrini,Pierre Ackerman,Raffaele Cavalli 한국산림과학회 2016 Forest Science And Technology Vol.12 No.2
Terrain access is a critical factor influencing the feasibility of forest operations in steep mountainous terrain. Long extraction distances coupled with terrain obstacles can favor the use of helicopters in timber extraction in such areas. However, helicopter logging in the Italian Alps is not commonplace when compared to other Alpine regions, for example, in Switzerland and Austria. The use of light-lift helicopters has recently caught the attention of practitioners as an alternative to more traditional medium- to heavy-lift aircraft in the Alps. This article reports the findings of two preliminary case studies using light-lift helicopters for the extraction of high value timber and fire-damaged timber subsequently exposed to bark beetle disturbance. In order to provide a comprehensive analysis of the factors affecting helicopter logging productivity, the two case studies were separately analyzed using time-element analysis supported by on-board global navigation satellite system (GNSS) devices. Additionally, an external video camera was used to continuously monitor the operations. The payload utilization was 86% for the extraction of high value timber and 70% for fire-damaged timber subsequently exposed to bark beetle disturbance. Variation in the turn time was mostly related to the hooking, choker return, and load times, as well as flying distance. Above all, the load hooking time explains c. 27% of the variance, revealing its critical influence on logging productivity.
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Alessandro Serretti,Chiara Fabbri,Silvia Pellegrini,Stefano Porcelli,Pierluigi Politi,Silvio Bellino,Marco Menchetti,Veronica Mariotti,Cristina Demi,Valentina Martinelli,Marco Cappucciati,Paola Bozzat 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.2
Objective-Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated. Methods-One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417). Results-IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome. Conclusion-Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
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이환종,조대선,김윤경,이현주,김경효,이도경,Carlo Curina,Marco Costantini,Silvia Barbi,Yan Miao,Michele Pellegrini 대한백신학회 2019 Clinical and Experimental Vaccine Research Vol.8 No.2
Purpose: Results from a post-marketing study to generate evidence on 1-year antibody persistence and safety following vaccination of infants from South Korea with the quadrivalent meningococcal conjugate vaccine MenACWY-CRM. Materials and Methods: In this phase IV, open-label, multi-center study (NCT02446691), 128 infants received MenACWY-CRM at ages 2, 4, 6, and 12 months. One-year antibody persistence following the full vaccination course was evaluated (primary objective) for the four meningococcal serogroups (Men) by serum bactericidal activity assay using human or rabbit complement (hSBA/rSBA). Immune responses at 1-month post-vaccination and safety were also assessed. Results: The percentage of children with hSBA titers ≥8 ranged between 94% (MenA) and 100% (MenY/W) 1-month post-vaccination, and from 39% (MenA) to 89% (MenY) 1-year post-vaccination. At least 99% and 92% of children had rSBA titers ≥8 and ≥128 against each meningococcal serogroup, 1-month post-vaccination. One-year post-vaccination, the percentage of children with rSBA titers ≥8 and ≥128 ranged from 54% (MenC) to 99% (MenA) and from 30% (MenC) to 98% (MenA). Geometric mean titers declined from 1-month to 1-year post-vaccination, when they varied between 6.8 (MenA) and 53.6 (MenW) by hSBA and between 17.2 (MenC) and 2,269.5 (MenA) by rSBA. At least one solicited and unsolicited adverse event was reported for 79% and 66% of children. Of 36 serious adverse events reported, none were vaccination-related. Conclusion: Antibody persistence (hSBA/rSBA titers ≥8) was determined in 39%-99% of children 1 year after a 4-dose MenACWY-CRM series during infancy, with an acceptable clinical safety profile.
KCI
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