W. Manson의 예수전

W. Manson 한신대학교 한신신학연구소 1955 신학연구 Vol.1 No.-

Theoretical study of the photoionization of the excited1s22s2pPo1,3states of theBe-likeB+ion

Kim, Dae-Soung,Manson, Steven T. American Physical Society 2005 Physical review. A. Atomic, molecular, and optical Vol.71 No.3

Photoionization of the Be-like O^{4 +} ion: total and partial cross sections for the ground 2s² ¹S and excited 2s2p ^{1, 3}P states

Kim, Dae-Soung,Manson, Steven T IOP Pub 2010 Journal of Physics B: Atomic, Molecular and Optica Vol.43 No.15

<P>Photoionization cross sections of the Be-like O<SUP>4 +</SUP> ion in the photon energy region from the first threshold up to the O<SUP>5 +</SUP> 3d threshold have been calculated using a non-iterative variational <I>R</I>-matrix method combined with multichannel quantum-defect theory for the ground 2s<SUP>2</SUP> <SUP>1</SUP>S and excited 2s2p <SUP>1, 3</SUP>P states. The partial cross sections are presented and the autoionizing resonance structures arising from the ground and excited states are identified and characterized. Our calculational results, which show excellent agreement between length and velocity gauges, are compared with the available experiment and previous calculations, and good agreement is found.</P>

Financial Exclusion and Strategic Corporate Social Responsibility

Kenneth Amaeshi,Abel Ezeoha,Bongo Adi,Manson Nwafor 피터드러커 소사이어티 2010 창조와 혁신 Vol.3 No.1

Sustainable finance is gradually gaining a centre stage in contemporary corporate social responsibility (CSR) discourse, especially through the growing legitimacy of social responsible investments (SRI). While most of the emerging trends in CSR-led sustainable finance could be arguably linked to dominant western (i.e. developed economies) CSR interests and ideologies, the socio-economic challenges posed by exclusion from access to financial services due to socio-economic conditions in developing economies, appear to be underrepresented in the extant CSR literature. In line with this observation and drawing from the Nigerian context, this paper examines the seeming ‘contradictory’ implications of financial exclusion for financial institutions operating in developing economies: first as a socio-economic malaise with potential adverse effects on firms’ profitability by, for instance, shrinking and limiting their market reach; and secondly as a source of strategic opportunities to enhance their brands as good corporate citizens and mitigate probable risk of 'harsh’ regulatory policies to combat financial exclusion. It further argues that by reducing financial exclusion, financial institutions in developing economies can contribute more meaningfully to the fight against poverty and social exclusion, and fill in a gap in sustainable finance discourse

Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia

Brian Tomlinson,Nivritti Gajanan Patil,Manson Fok,Christopher Wai Kei Lam 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.2

Patients with familial hypercholesterolemia (FH) are at high or very high risk for cardiovascular disease. Those with heterozygousFH (HeFH) often do not reach low-density lipoprotein cholesterol (LDL-C) targets with statin and ezetimibe therapy, and those withhomozygous FH (HoFH) usually require additional lipid-modifying therapies. Drugs that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) offer a novel approach to reduce LDL-C. The monoclonal antibodies, alirocumab and evolocumab, given bysubcutaneous injection every 2 or 4 weeks produce reductions in LDL-C of 50% to 60% in patients with HeFH, allowing many ofthem to achieve their LDL-C goals. Patients with HoFH show a reduced and more variable LDL-C response, which appears to depend on residual LDL receptor activity, and those with receptor-negative mutations may show no response. Inclisiran is a long-actingsmall interfering RNA therapeutic agent that inhibits the synthesis of PCSK9. Subcutaneous doses of 300 mg can reduce LDL-C bymore than 50% for at least 6 months and the responses in HeFH and HoFH patients are similar to those achieved with monoclonalantibodies. These PCSK9 inhibitors are generally well tolerated and they provide a new opportunity for effective treatment for themajority of patients with FH.

Trade in a small-range songbird, the Javan crocias, gives insight into the Asian Songbird Crisis

Vincent Nijman,Ahmad Ardiansyah,Rifqi Hendrik,Abdullah Langgeng,Sophie Manson,Katey Hedger,Muhammad Ali Imron,K. Anne-Isola Nekaris 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.2

The Asian Songbird Crisisdthe recognition that the cage bird trade is the number one threat to manysongbirdsdhas focussed on either individual bird markets or specific taxa. We here show, throughsustained monitoring, that even species that were not thought to be traded are also at risk from overexploitation. The Javan crocias Laniellus albonotatus is endemic to the montane forests of western Javaethis remoteness was thought to be the reason why it had escaped from being at risk. We surveyed21 bird markets over a 44-month period; the number of crocias recorded in markets (1.29 birds/survey)was negatively related to the distance to its habitat. The size of the bird market had no effect on thenumber of crocias we recorded. Prices (US$26.70/bird), when corrected for inflation, did not change over12 years suggesting supply can keep up with demand. Turnover is high (50% sold after 8 days), and weestimate the total trade at 1,200 to 1,500 birds/year. Legal protection of Javan crocias seen in isolationthus far is proven to be ineffective. A more inclusive approach where government bodies, conservationagencies and society participate, is needed to curb the trade in this and other imperiled songbirds.

Multimarker Prediction of Coronary Heart Disease Risk

Kim, H.C.,Greenland, P.,Rossouw, J.E.,Manson, J.E.,Cochrane, B.B.,Lasser, N.L.,Limacher, M.C.,Lloyd-Jones, D.M.,Margolis, K.L.,Robinson, J.G. Elsevier Biomedical 2010 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.55 No.19

Objectives: The aim of this study was to investigate whether multiple biomarkers contribute to improved coronary heart disease (CHD) risk prediction in post-menopausal women compared with assessment using traditional risk factors (TRFs) only. Background: The utility of newer biomarkers remains uncertain when added to predictive models using only TRFs for CHD risk assessment. Methods: The Women's Health Initiative Hormone Trials enrolled 27,347 post-menopausal women ages 50 to 79 years. Associations of TRFs and 18 biomarkers were assessed in a nested case-control study including 321 patients with CHD and 743 controls. Four prediction equations for 5-year CHD risk were compared: 2 Framingham risk score covariate models; a TRF model including statin treatment, hormone treatment, and cardiovascular disease history as well as the Framingham risk score covariates; and an additional biomarker model that additionally included the 5 significantly associated markers of the 18 tested (interleukin-6, d-dimer, coagulation factor VIII, von Willebrand factor, and homocysteine). Results: The TRF model showed an improved C-statistic (0.729 vs. 0.699, p = 0.001) and net reclassification improvement (6.42%) compared with the Framingham risk score model. The additional biomarker model showed additional improvement in the C-statistic (0.751 vs. 0.729, p = 0.001) and net reclassification improvement (6.45%) compared with the TRF model. Predicted CHD risks on a continuous scale showed high agreement between the TRF and additional biomarker models (Spearman's coefficient = 0.918). Among the 18 biomarkers measured, C-reactive protein level did not significantly improve CHD prediction either alone or in combination with other biomarkers. Conclusions: Moderate improvement in CHD risk prediction was found when an 18-biomarker panel was added to predictive models using TRFs in post-menopausal women.

Control of Cellular Bcl-x_L Levels by Deamidation-Regulated Degradation

Dho, So Hee,Deverman, Benjamin E.,Lapid, Carlo,Manson, Scott R.,Gan, Lu,Riehm, Jacob J.,Aurora, Rajeev,Kwon, Ki-Sun,Weintraub, Steven J. Public Library of Science 2013 PLoS biology Vol.11 No.6

<P>The cellular concentration of Bcl-x<SUB>L</SUB> is among the most important determinants of treatment response and overall prognosis in a broad range of tumors as well as an important determinant of the cellular response to several forms of tissue injury. We and others have previously shown that human Bcl-x<SUB>L</SUB> undergoes deamidation at two asparaginyl residues and that DNA-damaging antineoplastic agents as well as other stimuli can increase the rate of deamidation. Deamidation results in the replacement of asparginyl residues with aspartyl or isoaspartyl residues. Thus deamidation, like phosphorylation, introduces a negative charge into proteins. Here we show that the level of human Bcl-x<SUB>L</SUB> is constantly modulated by deamidation because deamidation, like phosphorylation in other proteins, activates a conditional PEST sequence to target Bcl-x<SUB>L</SUB> for degradation. Additionally, we show that degradation of deamidated Bcl-x<SUB>L</SUB> is mediated at least in part by calpain. Notably, we present sequence and biochemical data that suggest that deamidation has been conserved from the simplest extant metazoans through the human form of Bcl-x<SUB>L</SUB>, underscoring its importance in Bcl-x<SUB>L</SUB> regulation. Our findings strongly suggest that deamidation-regulated Bcl-x<SUB>L</SUB> degradation is an important component of the cellular rheostat that determines susceptibility to DNA-damaging agents and other death stimuli.</P><P><B>Author Summary</B></P><P>Cellular levels of the pro-survival protein Bcl-x<SUB>L</SUB> are an important determinant of cellular susceptibility to many death stimuli, including most cancer therapies. We previously showed that human Bcl-x<SUB>L</SUB> undergoes deamidation – the conversion of two neutral asparaginyl side-chains into negatively charged aspartyl side-chains – a process that occurs spontaneously but is accelerated by the treatment of tumor cells with DNA-damaging agents. Here, we show that deamidation activates a hitherto undetected signal sequence within Bcl-x<SUB>L</SUB> that targets it for degradation by a pathway involving the proteolytic enzyme calpain. This increased degradation of Bcl-x<SUB>L</SUB>, and the consequent enhanced cellular susceptibility to programmed cell death, may contribute to the ability of DNA-damaging agents to kill tumors. We also demonstrate that deamidation of Bcl-x<SUB>L</SUB> has likely been conserved from the simplest metazoans to humans, underscoring the importance of deamidation in the regulation of Bcl-x<SUB>L</SUB>.</P>

Spectral responsivity measurement of photovoltaic detectors by comparison with a pyroelectric detector on individual nano-second laser pulses

Hong, Kee-Suk,Park, Seongchong,Hwang, Jisoo,Atkinson, Errol,Manson, Peter,Lee, Dong-Hoon BUREAU INTERNATIONAL DES POIDS ET MESURES 2017 METROLOGIA -BERLIN- Vol.54 No.3

<P>We demonstrate that the individual single pulse of a nano-second laser can be used to measure the spectral responsivity of photovoltaic detectors. With this new scheme, the relative spectral responsivity of a photodiode can be determined from the spectral reflectance of the surface of a pyroelectric detector. We also developed the adequate data acquisition procedure, which can eliminate systematic errors caused by the nonlinear pulse response. The method is experimentally demonstrated for Si and Ge photodiodes in a wide wavelength range from 420 nm to 1600 nm and verified by comparison with the method using a CW source.</P>

Vibration-based structural health monitoring using large sensor networks

A. Deraemaeker,A. Preumont,E. Reynders,G. De Roeck,J. Kullaa,V. Lämsä,K. Worden,G. Manson,R. Barthorpe,E. Papatheou,P. Kudela,P. Malinowski,W. Ostachowicz,T. Wandowski 국제구조공학회 2010 Smart Structures and Systems, An International Jou Vol.6 No.3

Recent advances in hardware and instrumentation technology have allowed the possibility of deploying very large sensor arrays on structures. Exploiting the huge amount of data that can result in order to perform vibration-based structural health monitoring (SHM) is not a trivial task and requires research into a number of specific problems. In terms of pressing problems of interest, this paper discusses: the design and optimisation of appropriate sensor networks, efficient data reduction techniques, efficient and automated feature extraction methods, reliable methods to deal with environmental and operational variability, efficient training of machine learning techniques and multi-scale approaches for dealing with very local damage. The paper is a result of the ESF-S3T Eurocores project Smart Sensing For Structural Health Monitoring(S3HM) in which a consortium of academic partners from across Europe are attempting to address issues in the design of automated vibration-based SHM systems for structures.