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- 저자 : Manik (검색결과 45 건)
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Manik, Tumiar Katarina,Sidle, Roy Carl Institute of Forest Science 2018 Journal of Forest Science Vol.34 No.4
Sumber Jaya (54,194 hectares) is a district in West Lampung, Indonesia, located at the upper part of Tulang Bawang watershed. This watershed is one major water resource for Lampung Province, but has become a focal point of discussion because of the widespread conversion of forestland to coffee plantations and human settlements which lead to environmental and hydrological problems. This research aimed to evaluate Sumber Jaya watershed affecting by rapid land use change using hydrological methods as a base for watershed management. Nested catchment structure consisted of eight sub-catchments was employed in this research to assess scaling issues of land use change impacts on rainfall-runoff connections. Six tipping bucket rain gages were installed on the hill slopes of each sub-catchment and Parshall flumes were installed at the outlets of each sub-catchment to monitor stream flow. First, unit hydrograph that expressed the relationship of rainfall and runoff was computed using IHACRES model. Second, unit hydrograph was also constructed from observations of input and response during several significant storms with approximately equal duration. The result showed that most of the storm flow from these catchments consisted of slow flow. A maximum of about 50% of the effective rainfall became quick flow, and only less than 10% of remaining effective rainfall which was routed as slow flow contributed to hydrograph peaks; the rest was stored. Also, comparing peak responses and recession rates on the hydrograph, storm flow discharge was generally increased slowly on the rising limb and decreased rapidly on the falling limb. These responses indicated the soils in these catchments were still able to hold and store rain water.
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Manik, M.K.,Yang, H.,Tong, J.,Im, Y.J. Current Biology 2017 Structure Vol.25 No.4
<P>Yeast Osh1 belongs to the oxysterol-binding protein (OSBP) family of proteins and contains multiple targeting modules optimized for lipid transport at the nucleus-vacuole junction (NVJ). The key determinants for NVJ targeting and the role of Osh1 at NVJs have remained elusive because of unknown lipid specificities. In this study, we determined the structures of the ankyrin repeat domain (ANK), and OSBP-related domain (ORD) of Osh1, in complex with Nvj1 and ergosterol, respectively. The Osh1 ANK forms a unique bi-lobed structure that recognizes a cytosolic helical segment of Nvj1. We discovered that Osh1 ORD binds ergosterol and phosphatidylinositol 4-phosphate PI(4) P in a competitive manner, suggesting counter-transport function of the two lipids. Ergosterol is bound to the hydrophobic pocket in a head-down orientation, and the structure of the PI(4) P-binding site in Osh1 is well conserved. Our results suggest that Osh1 performs non-vesicular transport of ergosterol and PI(4) P at the NVJ.</P>
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Influence of the Dominant Follicle on the Superovulatory Response in Cattle
Manik, R.S.,Singla, S.K.,Palta, P.,Madan, M.L. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.4
Nine cows were superovulated by administration of 8 injections of Folltropin each (2.5 ml/injection, 1.75 mg/ml) i.m spread over 4 days, beginning on Day 10 of oestrous cycle, and 30 and 20 mg prostaglandin $F_{2{\alpha}}$ was given along with the 5th and 6th injections of Folltropin, respectively, to induce luteolysis. The animals were artificially inseminated 48, 60 and 72 h after the first prostaglandin $F_{2{\alpha}}$ injection. The number of corpora lutea was recorded by palpation per rectum and by ultrasonography on Day 6 (Day 0 = day of oestrus). The ovaries were examined daily by ultrasonography on Days 3-9 of the oestrous cycle for following the growth and regression of the largest follicle, which was considered the morphologically dominant follicle. The animals were classified into two groups depending upon the presence (n = 4) and absence of a dominant follicle (n = 5). There was a high correlation (r = 0.97, p < 0.001) between the number of corpora lutea observed by palpation per rectum and that determined by ultrasonography. Mean (${\pm}SEM$) number of corpora lutea determined by ultrasonography ($11.20{\pm}3.71$ vs $3.25{\pm}0.75$) and by palpation per rectum ($10.40{\pm}3.91$ vs $2.25{\pm}0.75$) was significantly higher (p < 0.05) in the nondominant group compared to that in the dominant group. There was no difference in the numbers of follicles 2-3 mm ($13.80{\pm}4.49$ vs $8.00{\pm}1.08$), 4-6 mm ($7.00{\pm}1.87$ vs $3.50{\pm}1.33$), and the total number of follicles ${\geq}2mm$ ($22.00{\pm}5.95$ vs $12.50{\pm}1.26$) between the two groups, one day prior to initiation of superovulation. There was, however, a significant (p<0.01) positive correlation between the number of corpora lutea with the numbers of follicles 2-3 mm (r = 0.83), 4-6 mm (r = 0.80) and the total number of follicles ${\geq}2mm$ (r = 0.89) observed one day prior to initiation of superovulation. The results of this study indicate that the presence of a dominant follicle adversely affects the superovulatory response in cattle.
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Manik, R.S.,Singla, S.K.,Palta, P.,Madan, M.L. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.5
The present study examined the follicular populations prior to and during superovulation and investigated their relationship with superovulatory response in crossbred cattle. Eleven animals were administered i.m. 8 doses of Folltropin of 2.5 ml each (1.75 mg/ml) spread over 4 days beginning on Day 10 of oestrous cycle, and 30 and 20 mg Lutalyse was given alongwith the 5th and 6th injections of Folltropin, respectively, to induce luteolysis. The animals were artificially inseminated 48, 60 and 72 h after the first Lutalyse injection. The number of corpora lutea (CL) was recorded by palpation per rectum and embryos were recovered non-surgically on Day 6 (Day 0 day of superoestrus). The ovarian follicular population was examined by transrectal Ultrasonography 15 h prior to and 52 h after the first FSH injection, and then on the day of superoestrus and the day of flushing. The follicles were classfied on the basis of diameter as small (3-5 mm), medium (6-9 mm) and large (${\geq}10mm$). The total number of follicles increased significantly (p < 0.01) from $2.45{\pm}0.35$, 15 h prior to the first FSH injection to $8.09{\pm}1.12$, 52 h after the first FSH injection and then further to $13.27{\pm}1.89 $ on the day of superoestrus. A positive correlation was observed between the number of small follicles 15 h prior to the first FSH injection (r = 0.60, p < 0.05), the number of large follicles 52 h after the first FSH injection (r=0.59, p < 0.05) and the number of CL. The follicular population prior to and during superovulation was, however, not significantly different between high (> 6 CL) and low responders (${\leq}6CL$). The present study suggests that the follicular populations undergo dynamic changes during superovulation and that follicular populations prior to superovulation have a limited application as an indicator of the superovulatory response.
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Conformers of Zwitterionic Glycine in Aqueous Phase
Manik Kumer Ghosh,최태훈,최철호 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.2
Zwitterionic glycine was investigated for its major conformers and their isomerizations in aqueous phase by QM/MM-MD. The rotameric barrier of zwitterionic glycine along C−C bond is approximately 2 kcal/mol higher than that of non-ionized one. It can be attributed to the strong electrostatic effects of zwitterion, which attracts water solvents more tightly. Unlike the previous quantum mechanical calculations, our QM/MM-MD found that only the gauche conformer as stable minima along the C−N bond rotation. Overall, the preferred conformers in real solution are different from those found with limited clusters, necessitating the use of QM/MM-MD.
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Comparative Follicular Dynamics in Superovulated Crossbred Cows and Water Buffaloes
Manik, R.S.,Singla, S.K.,Madan, M.L. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.1
To understand the caused for poor response to superovulation in water buffalo compared to crossbred cows, follicular events, before start of superovulation, during superovulation and after superovulation were compared. Follicular development was monitored a day before start of superovulation, daily upto superestrus and on the day of flushing. A real time B mode diagnostic instrument equipped with a linear array, 5 MHz transducer was used in five crossbred cows and five Murrah buffaloes. Crossbred cows yielded significantly (p < 0.01) higher number of corpora lutea than buffaloes (21 vs 10). The mean number of small size (2 to 5 mm); medium size (6 to 9 mm) and large size $({\geq}10mm)$ follicles, a day before start of superovulation were almost similar or even slightly higher in buffalo. Though initial shift in the mean number of follicles was higher in buffalo than cow, yet, from Day 2 to Day 3 of the treatment, the average increase in medium (3.2 vs 1.2) and large size (5.0 vs 2.0) follicles was higher in cows than buffaloes. The mean number of medium and large size follicles was 9.8 and 14.4 in cows and 6.4 and 7.6 in buffaloes. On the day of flushing, the number of large size follicle was more in buffaloes than cows, indicating the ovulation problem in this species. The major conclusion from this investigation was that, a day before start of superovulatory treatment, the number of small and medium size follicles was slightly higher in buffaloes, even then superovulatory response was better in cows, due to shift, recruitment and passage of follicles from smaller size to larger size from Day 2 of treatment. Ovulation problem in buffaloes was also responsible for lower superovulatory responses as revealed by the presence of higher number of large size follicles on the day of flushing.
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Manik, R.S.,Singla, S.K.,Palta, P.,Madan, M.L. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.5
Application of trans rectal ultrasonography to buffaloes (n=6) to follow the growth of large antral follicles individually, on each day of one interovulatory interval revealed that follicular turnover during oestrous cycle occured in waves. There was a predominance of a two-wave pattern (5/6 animals) compared to that of a three-wave pattern (1/6 animals). For two-wave pattern, the first wave emerged at Day $0.20{\pm}0.19$ (Day 0 = day of ovulation) and was marked by development of a dominant anovulatory follicle which grew in size from $5.40{\pm}0.24mm$ at the day of detection to a maximum diameter of $12.40{\pm}0.81mm$ on Day $8.60{\pm}1.57$, with a growth rate of $0.88{\pm}0.17mm/day$ and then regressed, with a mean persistence of $19.40{\pm}1.54$ days. The second wave emerged at Day $9.20{\pm}1.06$ and was marked by development of a dominant ovulatory follicle which grew in size from $4.20{\pm}0.37mm$ at the day of detection to a maximum diameter of $13.80{\pm}0.37mm$ on Day $21.00{\pm}1.38$, with a growth rate of $0.66{\pm}0.12mm/day$ and then ovulated on Day $21.60{\pm}1.25$, with a mean persistence of $11.80{\pm}1.39$ days. The maximum diameters attained and the growth rates of dominant anovulatory and dominant ovulatory follicles, and the mean number of follicles ${\geq}3mm$ diameter detected at the time of emergence of first and second waves ($11.80{\pm}1.74$ and $9.00{\pm}2.81$, respectively) were not significantly different. In the animal which showed a three-wave pattern, the first, second and third waves emerged on Days 1, 10 and 19, respectively. All animals, except one had at least one subordinate follicle in the first or second or both waves. The subordinate follicles increased in diameter over a few days and then regressed. The results indicate that in buffaloes, the follicular turnover during oestrous cycle occurs predominantly in a two-wave pattern.
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