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- 저자 : Manfred Wilhelm (검색결과 4 건)
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Yvonne MÖdinger,Christiane SchÖn,Manfred Wilhelm,Christina Pickel,Torsten Grothe 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.11
The plant Santa herba (Eriodictyon californicum) contains high flavonoids, thus potentially exerting beneficial effects in context of obesity, often accompanied by inflammation and metabolic imbalance. The study assessed the impact of Santa herba on oxidative stress, energy metabolism, weight reduction, and eating behavior, combining in vitro models with clinical data. Santa herba binding of the adenosine receptor A2A (ADORA2A) was assessed using a radioligand binding assay. A Caenorhabditis elegans model was used to determine mobility boosting effects, and Santa herba oxygen radical absorbance capacity (ORAC) values were determined in comparison to antioxidative plants. Clinical data, that is, body weight and appetite-related parameters, were obtained from overweight and obese women receiving either Santa herba or placebo for 12 weeks. Results showed that Santa herba extract binds to ADORA2A, stimulates C. elegans motility (+7.5%) and locomotion, and yields high antioxidative capacities (ORAC: 819 trolox equivalent). Clinical data, obtained from 24 overweight and 25 obese women (mean: 47.5 years), demonstrated a reduced body weight (P = .042) and body fat (P = .044), and by trend reduced leptin levels (P = .065) in women with obesity after Santa herba consumption compared to placebo. In conclusion, Santa herba extract has energizing and antioxidative properties and may aid in weight management of people with obesity.
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Ahirwal, Deepak,Palza, Humberto,Schlatter, Guy,Wilhelm, Manfred 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.3
In this article, a new way to characterize the percolation threshold of polymer nanocomposites made of polyethylene (PE) with single and multi walled carbon nanotubes (SWCNTs and MWCNTs) is presented. Small and large oscillatory shear (SAOS and LAOS) experiments were performed to characterize the degree of dispersion and percolation threshold. The analysis of the stress response in the LAOS regime as a function of the applied deformation amplitude and frequency was performed using Fourier Transform (FT)-Rheology. The zero strain intrinsic nonlinear parameter, $Q_0({\omega})$, was calculated by extrapolation of $I_{3/1}({\gamma}_0,{\omega})$ and was, used to quantify the nonlinearity measured by FT-Rheology. Interestingly, a drop in $Q_0$ as a function of the CNT weight fraction at a fixed frequency was found that was below the percolation threshold. This was followed by, a steep rise in $Q_0$ above the percolation threshold. Therefore, the new method based on this observation that is proposed and described with this article has the potential to lead to a better understanding of structure-property relationships in polymer nanocomposites.
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Deepak Ahirwal,Humberto Palza,Guy Schlatter,Manfred Wilhelm 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.3
In this article, a new way to characterize the percolation threshold of polymer nanocomposites made ofpolyethylene (PE) with single and multi walled carbon nanotubes (SWCNTs and MWCNTs) is presented. Small and large oscillatory shear (SAOS and LAOS) experiments were performed to characterize the degreeof dispersion and percolation threshold. The analysis of the stress response in the LAOS regime as a functionof the applied deformation amplitude and frequency was performed using Fourier Transform (FT)-Rheology. The zero strain intrinsic nonlinear parameter, Q0(ω), was calculated by extrapolation of I3/1(γ0, ω) andwas, used to quantify the nonlinearity measured by FT-Rheology. Interestingly, a drop in Q0 as a functionof the CNT weight fraction at a fixed frequency was found that was below the percolation threshold. Thiswas followed by, a steep rise in Q0 above the percolation threshold. Therefore, the new method based onthis observation that is proposed and described with this article has the potential to lead to a better understandingof structure-property relationships in polymer nanocomposites.
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Claudia Dafinger,Markus M. Rinschen,Lori Borgal,Carolin Ehrenberg,Sander G. Basten,Mareike Franke,Martin Höhne,Manfred Rauh,Heike Göbel,Wilhelm Bloch,F. Thomas Wunderlich,Dorien J. M. Peters,Dirk Tasch 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Ciliopathies comprise a large number of hereditary human diseases and syndromes caused by mutations resulting in dysfunction of either primary or motile cilia. Both types of cilia share a similar architecture. While primary cilia are present on most cell types, expression of motile cilia is limited to specialized tissues utilizing ciliary motility. We characterized protein complexes of ciliopathy proteins and identified the conserved AAA-ATPase Ruvbl1 as a common novel component. Here, we demonstrate that Ruvbl1 is crucial for the development and maintenance of renal tubular epithelium in mice: both constitutive and inducible deletion in tubular epithelial cells result in renal failure with tubular dilatations and fewer ciliated cells. Moreover, inducible deletion of Ruvbl1 in cells carrying motile cilia results in hydrocephalus, suggesting functional relevance in both primary and motile cilia. Cilia of Ruvbl1-negative cells lack crucial proteins, consistent with the concept of Ruvbl1-dependent cytoplasmic pre-assembly of ciliary protein complexes.
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