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- 저자 : Man Minh Vo (검색결과 2 건)
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Nguyen-Thach Tung,Man-Van Hung,Xuan-Minh Vo,Thanh-Hai Nguyen,Thi-Minh-Hue Pham 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.2
A novel dosage form integrating solid dispersion(SD) in orally disintegrating tablets (ODTs) wasdeveloped and optimized by the face-centered centralcomposite design to improve poorly soluble property andslow onset action time of felodipine (Fel). SD of Fel andhydroxypropyl methylcellulose E6 was prepared by solventevaporation method. Differential scanning calorimetry andfourier transforms infrared spectroscopy indicated that Feltransformed from crystalline to amorphous state by theformation of hydrogen bond between –N–H in Fel and O–Rin HPMC. The accelerated stability test in 45 C, 75 % RHdemonstrated that the optimized SD was stable in terms ofthe dissolution rate of Fel and thermodynamic property. The ODTs containing SD (Fel:HPMC E6 = 1:3) wereprepared by direct compression technique. The face-centeredcentral composite design with the ODT-SD wasemployed to investigate the effect of mannitol (X1),crospovidone XL (X2) on the ODT-SD disintegration time(Y1), % Fel released after 5 min (Y2) and the ODT-SDfriability (Y3). ANOVA test showed that X2 and X2 * X2had a significant effect on the ODT-SD disintegration time(p\0.05). Meanwhile, the dissolution rate of Fel after5 min did not remarkably depend on any independentvariables (p[0.05). The ODT-SD friability was substantiallyproportional to the amount of mannitol (X1)(p\0.05). The optimized ODT-SD disintegration time, %Fel released after 5 min, and friability were 27.67 s, 88.35and 0.48 %, respectively.
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Tien Huynh Manh,Khanh Quoc Le Tran,Phat Tan Ho,Man Minh Vo,Thong Quang Pham,Thong Duy Vo 대한소화기학회 2023 대한소화기학회지 Vol.81 No.6
Strongyloidiasis, a chronic helminth infection caused by the parasitic nematode Strongyloides stercoralis, has various clinical manifestations. Although rare, duodenal obstructions and venous thromboembolism are possible complications of strongyloidiasis. This paper presents the case of a 47-year-old Vietnamese male with a history of right lower limb edema, anorexia, nausea, vomiting, diarrhea, and abdominal discomfort lasting for four months. Venous Doppler ultrasound detected a thrombus in the right femoral vein, while an abdominal CT scan revealed a mass lesion suggestive of a lower bile duct tumor. Esophageogastroduodenoscopy showed a friable duodenal cap mucosa with multiple ulcers and edematous mucosa of the second part of the duodenum that caused a partial lumen obstruction. The final histological examination of the biopsy specimen revealed chronic duodenitis with larvae consistent with Strongyloides stercoralis. The patient was treated with Ivermectin for two weeks and anticoagulation therapy for three months. After treatment and a six-month follow-up, the patient's gastrointestinal symptoms and leg swelling resolved completely. This is the first documented case of a patient in Vietnam with strongyloidiasis who presented with venous thromboembolism and duodenal obstruction.
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