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RISS 인기검색어
- 검색키워드
- 저자 : Mahshid Mostafavi (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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A Novel Niosomal Combination of Selenium Coupled with Glucantime against Leishmania tropica
Mahshid Mostafavi,Payam Khazaeli,Iraj Sharifi,Saeedeh Farajzadeh,Hamid Sharifi,Alireza Keyhani,Maryam Hakimi Parizi,Sina Kakooei 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.1
There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. In this study, the niosomal formulations of selenium and in combination with glucantime were prepared. The size and morphology of the niosomal formulations were charac- terized and the effectivity of the new formulation was also evaluated using in vitro MTT assay, intra-macrophage model, and gene expression profile. From the results obtained, no cytotoxicity effect was observed for niosomal and simple forms of drugs, as alone or in combination. Niosomal formulations of the drugs significantly showed more inhibitory ef- fects (P ≤ 0.001) than the simple drugs when the selectivity index was considered. The gene expression levels of Interleu- kin (IL-10) significantly decreased, while the level of IL-12 and metacaspase significantly increased (P ≤ 0.001). The results of the present study showed that selenium plus glucantime niosome possess a potent anti-leishmanial effect and en- hanced their lethal activity as evidenced by the in vitro experiments.
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Prevalence of latent tuberculosis infection among tuberculosis laboratory workers in Iran
Mahshid Nasehi,Abdolrazagh Hashemi-Shahraki,Amin Doosti-Irani,Saeed Sharafi,Ehsan Mostafavi 한국역학회 2017 Epidemiology and Health Vol.39 No.-
OBJECTIVES: The risk of transmission of Mycobacterium tuberculosis from patients to health care workers (HCWs) is a neglected problem in many countries, including Iran. The aim of this study was to estimate the prevalence of latent tuberculosis (TB) infection (LTBI) among TB laboratory staff in Iran, and to elucidate the risk factors associated with LTBI. METHODS: All TB laboratory staff (689 individuals) employed in the TB laboratories of 50 Iranian universities of medical sciences and a random sample consisting of 317 low-risk HCWs were included in this cross-sectional study. Participants with tuberculin skin test indurations of 10 mm or more were considered to have an LTBI. RESULTS: The prevalence of LTBI among TB laboratory staff and low-risk HCWs was 24.83% (95% confidence interval [CI], 21.31 to 27.74%) and 14.82% (95% CI, 11.31 to 19.20%), respectively. No active TB cases were found in either group. After adjusting for potential confounders, TB laboratory staff were more likely to have an LTBI than low-risk HCWs (prevalence odds ratio, 2.06; 95% CI, 1.35 to 3.17). CONCLUSIONS: This study showed that LTBI are an occupational health problem among TB laboratory staff in Iran. This study reinforces the need to design and implement simple, effective, and affordable TB infection control programs in TB laboratories in Iran.
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Ehsan Mostafavi,Mahshid Nasehi,Abdolrazagh Hashemi Shahraki,Saber Esmaeili,Ebrahim Ghaderi,Saeed Sharafi,Amin Doosti-Irani 한국역학회 2016 Epidemiology and Health Vol.38 No.-
OBJECTIVES: The tuberculin skin test (TST) and the QuantiFERON-TB Gold test (QFT) are used to identify latent tuberculosis infections (LTBIs). The aim of this study was to determine the agreement between these two tests among health care workers in Iran. METHODS: This cross-sectional study included 177 tuberculosis (TB) laboratory staff and 67 non-TB staff. TST indurations of 10 mm or more were considered positive. The Student’s t-test and the chi-square test were used to compare the mean score and proportion of variables between the TB laboratory staff and the non-TB laboratory staff. Kappa statistics were used to evaluate the agreement between these tests, and logistic regression was used to assess the risk factors associated with positive results for each test. RESULTS: The prevalence of LTBIs according to both the QFT and the TST was 17% (95% confidence interval [CI], 12% to 21%) and 16% (95% CI, 11% to 21%), respectively. The agreement between the QFT and the TST was 77.46%, with a kappa of 0.19 (95% CI, 0.04 to 0.34). CONCLUSIONS: Although the prevalence of LTBI based on the QFT and the TST was not significantly different, the kappa statistic was low between these two tests for the detection of LTBIs.
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