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Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?
Macedo, Filipa,Ladeira, Katia,Longatto-Filho, Adhemar,Martins, Sandra F. The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.1
Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: "Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]". A total of 30 articles were initially collected, and 4 were subsequently excluded. Among the 26 articles collected, 16 examined the role of vascular endothelial growth factor (VEGF), 4 studied endostatin, 3 investigated angiopoietin (Ang)-2, 2 studied the Ang-like protein 2 (ANGTPL2), and 1 each examined interleukin (IL)-12, IL-8, and hypoxia inducible factor. Regarding VEGF, 6 articles concluded that the protein was related to lymph node metastasis or distant metastases. Five articles concluded that VEGF levels were elevated in the presence of GC and decreased following tumor regression, suggesting that VEGF levels could be a predictor of recurrence. Four articles concluded that high VEGF levels were correlated with poor prognosis and lower survival rates. Ang-2 and ANGTPL2 were elevated in GC and associated with more aggressive disease. Endostatin was associated with intestinal GC. VEGF is the most extensively studied angiogenic factor. It is associated with the presence of neoplastic disease and lymph node metastasis. It appears to be a good biomarker for disease progression and remission, but not for diagnosis. The data regarding other biomarkers are inconclusive.
Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?
Filipa Macedo,Kátia Ladeira,Adhemar Longatto-Filho,Sandra F. Martins 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1
High levels of angiogenic and growth factors in serum and tumors are associated with worse outcomes in patients with gastric carcinomas. VEGF-A, the most extensively studied angiogenic factor, appears to be a useful biomarker for disease progression and remission, but not for diagnosis.
Juliana Alves Macedo,Lara Duraes Sette,Helia Harumi Sato 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.5
Covalent cross-links between a number of proteins and peptides explain why transglutaminase may be widely used by food processing industries. The objective of this work was optimization of the fermentation process to produce transglutaminase from a new microbial source, the Streptomyces sp. P20. The strategy adopted to modify the usual literature media was: (1) fractional factorial design (FFD) to elucidate the key medium ingredients, (2) central composite design (CCD) to optimise the concentration of the key components. Optimization of the medium resulted in not only an 86% increase in microbial transglutaminase activity as compared to the media cited in the literature, but also a reduction in the production cost. Optimal fermentation conditions - namely temperature and agitation rate - were also studied, using CCD methodology. Usual conditions of 30℃ and 100 rpm were within the optimal area. All other parameters for enzyme production were experimentally proven to be optimum fermentation conditions.
Daniel A. Macedo,Graziele L. Souza,Moisés R. Cesário,Beatriz Cela,Antonio E. Martinelli,Carlos A. Paskocimas,Rubens M. Nascimento 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.6
In this study, a chemical route was adopted to obtain strontium-doped lanthanum manganite (LaSrMnO3 or LSM) powders in order to prepare LaSrMnO3-4YSZ (4 mol% Y2O3) composite films by the suspension spin coating method onto 4YSZ and 8YSZ/8YSZ-NiO substrates with or without the application of a zirconia interlayer in the film/substrate interface. The multilayers were sintered at 1150 oC for 6 h and the effect of the interlayer on the morphological properties of the films has been investigated by scanning electron microscopy. The results show that in the less roughn substrates the application of the interlayer (~500 nm) not only improved the adhesion in the film/substrate interface, but also avoided new coating failures. All the films were porous, crack-free and with a thickness below 30 μm, desirable features for application as SOFC cathodes.
Asimilación Socioeconómica de los Jóvenes de Origen Mexicano en Estados Unidos
Alejandro Roman Macedo 부산외국어대학교 중남미지역원 2014 이베로아메리카 Vol.16 No.2
The level of formal education of migrants and their descendants in the United States is an indicator which, according to different theories of assimilation, lets know if migrants and their descendants are assimilating or not to the host society. In this regard some studies have indicated that assimilation will be different according to the socioeconomic segment of society in which migrants and their descendants are inserted. This theory considers that those who belong to a segment of middle and high income will have greater opportunities to assimilate socio-economically; that is because persons are located in contexts that allow them access to better educational services. Moreover, those who are in the low income segment will have access to lower educational quality schools and their opportunities to ascend socially will be limited. The aim of this article is to analyze, for 2003 and 2010, the segmented assimilation of Mexican origin youth in the United States, through the educational level reached. The hypothesis that will guide this analysis means that Mexican origin youth in the United States will present differences in its socioeconomic assimilation in different generations and income segments. It would be expected that the second and third generations have greater assimilation (similar educational achievements to the natives) in both segments of income.
Ossifying fibroma in the maxilla and orbital floor: report of an uncommon case
Diogo de Vasconcelos Macedo,Gabriely Ferreira,Eduardo Hochuli Vieira,Marcelo Silva Monnazzi 대한구강악안면외과학회 2020 대한구강악안면외과학회지 Vol.46 No.3
Benign fibro-osseous lesions occur when normal bone is replaced by cellular fibrous connective tissue and mineralized structures. One rare type of these lesions is the ossifying fibroma (OF). The aim of this study is to report an unusual case of OF in a 57-year-old female. Physical examination showed facial asymmetry without any tenderness, fluctuation, ocular pain, or ophthalmoplegia. Imaging exams revealed a solid mass involving the left maxilla and orbital floor. Surgical resection was performed without any complications or sequelae, and the histopathological results confirmed OF. Although recurrence is rare in this condition, the patient remains under follow-up.
On the Security Aspects of Internet of Things: A Systematic Literature Review
Evandro L. C. Macedo,Egberto A. R. de Oliveira,Fabio H. Silva,Rui R. Mello Jr,Felipe M. G. França,Flavia C. Delicato,José F. de Rezende,Luís F. M. de Moraes 한국통신학회 2019 Journal of communications and networks Vol.21 No.5
Internet of Things (IoT) has gained increasing visibilityamong emerging technologies and undoubtedly changing our dailylife. Its adoption is strengthened by the growth of connected devices(things) as shown in recent statistics. However, as the numberof connected things grows, responsibility related to security aspectsalso needs to increase. For instance, cyberattacks might happenif simple authentication mechanisms are not implemented on IoTapplications, or if access control mechanisms are weakly defined. Considering the relevance of the subject, we performed a systematicliterature review (SLR) to identify and synthesize security issuesin IoT discussed in scientific papers published within a periodof 8 years. Our literature review focused on four main security aspects,namely authentication, access control, data protection, andtrust. We believe that a study considering these topics has the potentialto reveal important opportunities and trends related to IoTsecurity. In particular, we aim to identify open issues and technologicaltrends that might guide future studies in this field, thusproviding useful material both to researchers and to managers anddevelopers of IoT systems. In this paper, we describe the protocoladopted to perform the SLR and present the state-of-the-art on thefield by describing the main techniques reported in the retrievedstudies. To the best of our knowledge, ours is the first study tocompile information on a comprehensive set of security aspects inIoT. Moreover, we discuss the placement, in terms of architecturaltiers, for deploying security techniques, in an attempt to provideguidelines to help design decisions of security solution developers. We summarize our results showing security trends and researchgaps that can be explored in future studies.
Anode power deposition in dry EDM
Felipe T. B. Macedo,Moritz Wiessner,Christoph Hollenstein,Caroline P. Martendal,Friedrich Kuster,Konrad Wegener 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.2
Dry electrical discharge machining (DEDM) has been developed as an environmentally friendlier alternative to the traditional EDM in oil-based dielectric. Proper understanding of the physics of the DEDM discharges is necessary in order to improve this new manufacturing technology, since its workpiece material removal and tool electrode wear mechanisms are governed by plasma-material interactions. The present work proposes the application of theoretical models, numerical simulations, and advanced diagnostics from the field of plasma physics as effective tools to estimate the electric discharge power deposition onto the anode workpiece in DEDM. Collisional-radiative models are used here to calculate several plasma properties, from which the anode power deposition can be estimated. In addition, electrical circuit simulations, which use a modified Cassie-Mayr model, calculate the fraction of the total electric discharge power that is consumed by thermal conduction into the anode electrode material. The methods proposed in the present work provide fundamental information for further workpiece material erosion modelling and simulation under different DEDM processing conditions.