http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Maximiliano Garcia ),( Rene Mendez ),( Aida Galicia ),( Efrain Garrido ),( Glustein Pozo ),( Edgar Moran ),( Norma Herrera ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Rheumatoid Arthritis (RA) is the most common autoimmune disease worldwide. T cells and their cytokines play a key role in the etiopathogenesis of this illness. In the last two decades IL-17A has shown to play a major role in the disease pathogenesis. Previous research on the SNP (Single Nucleotide Polymorphism) rs3804513 has shown a link to radiological progression in patients with RA. Objetive: To determine the correlation between rs3804513 IL-17A SNP and the risk of developing RA, and assess the relation between rs3804513 SNP and the severity of the disease. Methods: Oral epithelial cells were obtained as source for genetic material. The DNA was ampli. ed using Polymerase Chain Reaction. Subsequently, a Restriction Fragment Length Polymorphism was performed. finally, in order to con. rm the SNP presence, direct sequencing of the DNA was performed. We used a case-control design. Results: 76 patients with RA and 94 healthy subjects were included. Of the 76 patients evaluated, 15% (n=12) tested positive for SNP rs3804513 vs 3 % (n=3) subjects in the control group. An odds ratio (OR) of 5.6 (p=0.01) for developing RA was obtained in RA patients carrying the studied SNP. Interestingly, a large percentage of patients who tested positive required 3 DMARDs to control the disease in comparison to patients who tested negative: 73% vs 32% (OR 5.6, p<0.01). Conclusions: The SNP rs3804513 is a risk factor for developing RA. Furthermore, carriers need more aggressive treatment to control the disease.
CCD SNAPSHOTS OF FIELDS IN A STUDY OF THE VERTICAL DISTRIBUTION OF STARS
CHEN ALFRED B.,TSAY WEAN-SHUN,LU PHILLIP K.,SMITH ALLYN,MENDEZ RENE The Korean Astronomical Society 1996 Journal of The Korean Astronomical Society Vol.29 No.suppl1
Snapshots of eight SA and standard fields from low to high galactic latitudes were made using the KPNO 0.9m 2K $\times$ 2K CCD with a limiting magnitude from 19 to 22.5. The purpose of this study is to determine the vertical distribution of stars with respect to Galactic latitude and z-distance in comparison with the model simulation between intermediate population to the 'thick disk' component of scale height of a few kpc. Comparison of the preliminary results between observed and model simulation for 3 of the S fields shows good agreement both in V-mag and B- V color distributions. A bimodal distribution in B- V at high galactic latitude seems to be represented by a halo and 'thick disk' dwarf in the blue and by a normal disk dwarf population in the red.