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RISS 인기검색어
- 검색키워드
- 저자 : M. Ramakrishna Rao (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
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A Pilot Study of Open Label Sesame Oil in Hypertensive Diabetics
D. Sankar,M. Ramakrishna Rao,G. Sambandam,K.V. Pugalendi 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
The objective of this study was to investigate the effect of sesame oil in hypertensive diabetics medicated withatenolol (.-blocker) and glibenclamide (sulfonylurea). This open label trial with two intervention periods comprised 22 maleand 18 female patients, 4565 years old, with mild to moderate hypertension and diabetes. Sesame oil (Idhayam Gingelly™oil, V.V.V. & Sons, Virudhunagar, Tamilnadu, India) was supplied to the patients, who were instructed to use it in place ofother cooking oils for 45 days. Blood pressure (BP), anthropometric measurements, plasma glucose, glycated hemoglobin(HbA1c), lipid profiles [total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein choles-terol, and triglycerides (TG)], lipid peroxidation [thiobarbituric acid-reactive substances (TBARS)], electrolytes (sodium, potas-sium, and chloride), and enzymic (superoxide dismutase, glutathione peroxidase, and catalase) and nonenzymic (vitamin C,vitamin E, .-carotene, and reduced glutathione) antioxidants were measured at baseline and after 45 days of sesame oil sub-stitution. The same patients were then switched over to other oils like palm or groundnut oils as their regular oils at randomfor another 45 days, and the investigations were carried out again at the end. Systolic and diastolic BP decreased remarkably.When oil substitution was withdrawn, BP values rose again. Body weight, body mass index, girth of waist, girth of hip, andwaist:hip ratio were reduced upon substitution of sesame oil. Plasma glucose, HbA1c, TC, LDL-C, and TG were decreased.TBARS level was reduced, while the activities of enzymic and the levels of nonenzymic antioxidants were increased. Plasmasodium levels were reduced, while potassium levels were elevated. These results indicate that substitution of sesame oil asthe sole edible oil has an additive effect in further lowering BP and plasma glucose in hypertensive diabetics.
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