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- 검색키워드
- 저자 : M. Rafiei (검색결과 2 건)
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M. Jafari,M. Rafiei,H. Mostaan 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.10
In this investigation, the microstructure and mechanical properties of AISI420/SAF2507 dissimilar joint produced by TLPprocess were investigated at different bonding times. For this purpose, TLP process was carried out in a vacuum furnace at1050 °C using BNi-2 interlayer. The microstructure of different areas of the joint was evaluated by optical microscopy, scanningelectron microscopy and energy dispersive spectroscopy. Also, the mechanical properties of the bonded samples werestudied using microhardness and shear-tensile tests. It was found that isothermal solidification was completed after 60 minof bonding time. The width of DAZ in SAF2507 steel side was greater than that of AISI420 steel side at all bonding timesowing to the easier volume diffusion of boron in to the fully austenitic structure of AISI420 steel as compared with dualcrystal structure of SAF2507 steel. At bonding time of 60 min, by regarding the more time for diffusion as compared with1 min, boride compounds dissolved in the base metals and were discontinued. Thus, the aggregation of boride compoundsdecreased and as a result the microhardness decreased. In fully isothermal solidification sample, due to the lack of eutecticand intermetallic compounds and creating a homogenous joint (γ-Ni phase), the strength increased. In fact, transformationof athermal solidification to isothermal solidification led to the increase of the joint strength.
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Shaghayegh Askarian-Amiri,Solmaz Nasseri Maleki,Seyedeh Niloufar Rafiei Alavi,Arian Madani Neishaboori,Amirmohammad Toloui,Mohammed I. M. Gubari,Arash Sarveazad,Mostafa Hosseini,Mahmoud Yousefifard 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1
Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials.
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