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Wang, Shou-Zhen,Lee, Seok-Yong,Zhu, Sheng-Zu,Wotta, Diane R.,Parsons, Ann M.,El-Fakahany, Esam E. 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
We investigated the coupling of the M2 muscarinic acetylcholine receptors expressed in Chinese hamster ovary cells to activation of neuronal nitric oxide(NO) synthase. Stimulation of guanylate cyclase activity in detector neuroblastoma cells was used as an indirect measure of the generation of NO in Chinese hamster ovary cells. The muscarinic agonist carbachol induced marked time-and concentration-dependent enhancement of the activity of NO synthase. Activation of neuronal NO synthase by M2 muscarinic receptors was associated with a small increase in the concentration of intracellular Ca^2+. These data suggest the presence of alternate mechanisms of activation of neuronal NO synthase which might be operative in the absence of large changes in the concentration of cellular Ca^2+. These findings help to understand the mechanisms of activation of NO synthase.
Ndel1 and Reelin Maintain Postnatal CA1 Hippocampus Integrity
Jiang, Yulan,Gavrilovici, Cezar,Chansard, Mathieu,Liu, Rui Han,Kiroski, Ivana,Parsons, Kari,Park, Sang Ki,Teskey, G. Campbell,Rho, Jong M.,Nguyen, Minh Dang Society for Neuroscience 2016 The Journal of neuroscience Vol.36 No.24
<P>How the integrity of laminar structures in the postnatal brain is maintained impacts neuronal functions. Ndel1, the mammalian homolog of NuDE from the filamentous fungus Aspergillus nidulans, is an atypical microtubule (MT)-associated protein that was initially investigated in the contexts of neurogenesis and neuronal migration. Constitutive knock-out mice for Ndel1 are embryonic lethal, thereby necessitating the creation a conditional knock-out to probe the roles of Ndel1 in postnatal brains. Here we report that CA1 pyramidal neurons from mice postnatally lacking Ndel1 (Ndel1 conditional knock-out) exhibit fragmented MTs, dendritic/synaptic pathologies, are intrinsically hyperexcitable and undergo dispersion independently of neuronal migration defect. Secondary to the pyramidal cell changes is the decreased inhibitory drive onto pyramidal cells from interneurons. Levels of the glycoprotein Reelin that regulates MTs, neuronal plasticity, and cell compaction are significantly reduced in hippocampus of mutant mice. Strikingly, a single injection of Reelin into the hippocampus of Ndel1 conditional knock-out mice ameliorates ultrastructural, cellular, morphological, and anatomical CA1 defects. Thus, Ndel1 and Reelin contribute to maintain postnatal CA1 integrity.</P>
Hyde, G K,McCullen, S D,Jeon, S,Stewart, S M,Jeon, H,Loboa, E G,Parsons, G N Institute of Physics Pub 2009 Biomedical materials Vol.4 No.2
<P>Atomic layer deposition (ALD) is investigated as a process to produce inorganic metallic bio-adhesive coatings on cellulosic fiber substrates. The atomic layer deposition technique is known to be capable of forming highly conformal and uniform inorganic thin film coatings on a variety of complex surfaces, and this work presents an initial investigation of ALD on porous substrate materials to produce high-precision biocompatible titanium oxynitride coatings. X-ray photoelectron spectroscopy (XPS) confirmed TiNO<I><SUB>x</SUB></I> composition, and transmission electron microscopy (TEM) analysis showed the coatings to be uniform and conformal on the fiber surfaces. Biocompatibility of the modified structures was determined as a function of coating layer thickness by fluorescent live/dead staining of human adipose-derived adult stem cells (hADSC) at 6, 12 and 24 h. Cell adhesion showed that thin TiNO<I><SUB>x</SUB></I> coatings yielded the highest number of cells after 24 h with a sample coated with a 20 Å coating having approximately 28.4 ± 3.50 ng DNA. By altering the thickness of the deposited film, it was possible to control the amount of cells adhered to the samples. This work demonstrates the potential of low temperature ALD as a surface modification technique to produce biocompatible cellulose and other implant materials.</P>
The Properties of Planck Galactic Cold Clumps in the L1495 Dark Cloud
Tang, Mengyao,Liu, Tie,Qin, Sheng-Li,Kim, Kee-Tae,Wu, Yuefang,Tatematsu, Ken’ichi,Yuan, Jinghua,Wang, Ke,Parsons, Harriet,Koch, Patrick M.,Sanhueza, Patricio,Ward-Thompson, D.,Tó,th, L. Viktor,S American Astronomical Society 2018 The Astrophysical journal Vol.856 No.2
Does humeral fixation technique affect long-term outcomes of total shoulder arthroplasty?
Troy Li,Kenneth H. Levy,Akiro H. Duey,Akshar V. Patel,Christopher A. White,Carl M. Cirino,Alexis Williams,Kathryn Whitelaw,Dave Shukla,Bradford O. Parsons,Evan L. Flatow,Paul J. Cagle 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.3
Background: For anatomic total arthroscopic repair, cementless humeral fixation has recently gained popularity. However, few studies have compared clinical, radiographic, and patient-reported outcomes between cemented and press-fit humeral fixation, and none have performed follow-up for longer than 5 years. In this study, we compared long-term postoperative outcomes in patients receiving a cemented versus press-fit humeral stem anatomic arthroscopic repair. Methods: This study retrospectively analyzed 169 shoulders that required primary anatomic total shoulder arthroplasty (aTSA). Shoulders were stratified by humeral stem fixation technique: cementation or press-fit. Data were collected pre- and postoperatively. Primary outcome measures included range of motion, patient reported outcomes, and radiographic measures. Results: One hundred thirty-eight cemented humeral stems and 31 press-fit stems were included. Significant improvements in range of motion were seen in all aTSA patients with no significant differences between final cemented and press-fit stems (forward elevation: P=0.12, external rotation: P=0.60, and internal rotation: P=0.77). Patient reported outcome metrics also exhibited sustained improvement through final follow-up. However, at final follow-up, the press-fit stem cohort had significantly better overall scores when compared to the cemented cohort (visual analog score: P=0.04, American Shoulder and Elbow Surgeon Score: P<0.01, Simple Shoulder Test score: P=0.03). Humeral radiolucency was noted in two cemented implants and one press-fit implant. No significant differences in implant survival were observed between the two cohorts (P=0.75). Conclusions: In this series, we found that irrespective of humeral fixation technique, aTSA significantly improves shoulder function. However, within this cohort, press-fit stems provided significantly better outcomes than cemented stems in terms of patient reported outcome scores.
Troy Li,Akiro H. Duey,Christopher A. White,Amit Pujari,Akshar V. Patel,Bashar Zaidat,Christine S. Williams,Alexis Williams,Carl M. Cirino,Dave Shukla,Bradford O. Parsons,Evan L. Flatow,Paul J. Cagle 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.3
Background: In the past decade, the number of anatomic total shoulder arthroplasty (aTSA) procedures has steadily increased. Patients over 65 years of age comprise the vast majority of recipients, and outcomes have been well documented; however, patients are opting for definitive surgical treatment at younger ages.We aim to report on the effects of age on the long-term clinical outcomes following aTSA. Methods: Among the patients who underwent TSA, 119 shoulders were retrospectively analyzed. Preoperative and postoperative clinical outcome data were collected. Linear regression analysis (univariate and multivariate) was conducted to evaluate the associations of clinical outcomes with age. Kaplan-Meier curves and Cox regression analyses were performed to evaluate implant survival. Results: At final follow-up, patients of all ages undergoing aTSA experienced significant and sustained improvements in all primary outcome measures compared with preoperative values. Based on multivariate analysis, age at the time of surgery was a significant predictor of postoperative outcomes. Excellent implant survival was observed over the course of this study, and Cox regression survival analysis indicated age and sex to not be associated with an increased risk of implant failure. Conclusions: When controlling for sex and follow-up duration, older age was associated with significantly better patient-reported outcome measures. Despite this difference, we noted no significant effects on range of motion or implant survival.