Characterization and dielectric studies of hydrogen-beam-irradiated PDMS polymeric materials

Haifa A. Al‑Yousef,B. M. Alotaibi,A. Atta,M. M. Abdel‑Hamid 한국고분자학회 2023 Macromolecular Research Vol.31 No.8

In this work, PDMS films are treated with varying fluence of hydrogen ion beams (6 × 1017, 9 × 1017, and 12 × 1017 ions/cm2) for used in storage energy devices. XRD and FTIR were used to analyze the PDMS films. Furthermore, the SEM is employed to study the morphological alterations in treated PDMS films. Both XRD and FTIR result indicated that PDMS is chemically interacting after ion treatment. In addition, the dielectric parameters of PDMS films are measured using an LCR device in the frequencies 102–106 Hz. After PDMS exposed to 12 × 1017 ions/cm2, the dielectric constant of the PDMS increased from 23.4 to 44.8, and energy density increased from 1.01 × 10–4 to 1.92 × 10–4 J/m3, while the conductivity increased from 0.29 × 10–7 to 4.3 × 10–7 S/cm. Moreover, the real M′ decreased from 0.198 for PDMS to 0.165 for 6 × 1017 ions/cm2 and to 0.052 at 12 × 1017 ions/cm2, while the imaginary M″ is decreased from 0.205 to 0.155 for 6 × 1017 ions/cm2, and to 0.069 for 12 × 1017 ions/cm2. The studies indicated that the structure as well as electrical characteristics of the treated PDMS had been improved, which allowing being used these substances in different electronic instrumentations.

Low energy irradiation induced effects on the surface characteristics of polydimethylsiloxane polymeric films

B. M. Alotaibi,A. Atta,M. R. Atta,E. Abdeltwab,M. M. Abdel-Hamid 한국고분자학회 2023 Macromolecular Research Vol.31 No.1

This work attempts to modify the hydrophilic-adherence properties of polydimethylsiloxane (PDMS) by exposing to oxygen beam for used in painting, printing, and clothing applications. The structural and morphology changes of irradiated PDMS films are analyzed using XRD and SEM, respectively. The chemical functional group is investigated by Fourier infrared spectroscopy (FTIR). The contact angle for water is reduced from 81.38° to 42.50°, while the contact angle for diiodomethane is reduced from 63.20° to 25.40° by varying the irradiation time from 1.5 to 6 min. On the other hand, for water liquid, the adhesion work is enhanced from 82.75 to 125.5 mJ/m2, and for diiodomethane liquid, it’s increased from 73.70 to 96.68 mJ/m2. Moreover, the polar energy γsp is enhanced from 6.44 to 20.25 mJ/m2, while, the γsd is increased from 26.73 to 46.01 mJ/m2, and the total γst is increased from 33.18 to 66.26 mJ/m2 by enhancing exposing time 1.5–6 min. The improvement in the adhesion and surface energy of the irradiated PDMS films is due to oxygen ion beam induced decreasing in PDMS surface hydrophobicity. The experimental data show the surface morphology, structure and surface properties of treated PDMS are modified and depend closely on the oxygen beam irradiation time.

A review of polymeric nanocomposite membranes for water purification

M. Bassyouni,M.H. Abdel-Aziz,M.Sh. Zoromba,S.M.S Abdel-Hamid,Enrico Drioil 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.73 No.-

Nanocomposites are now commonly employed to augment the standard polymeric membrane materialsthat are used in water treatment processes. A number of different materials and methods have been putforward; amongst those that show the greatest promise so far are thin-film nanocomposite (TFN),electrospun polymeric nanofibrous membranes, carbon nanotubes, metal and metal oxides, grapheneand graphene oxide, and zwitterionic materials. This paper presents a detailed review of the currentdevelopments in the use of polymeric nanocomposite membranes for purifying water. Variousnanocomposite membranes have been reported to evaluate their effectiveness in terms of resistance tofouling and the performance of the membranes. A specific focus has been placed on better understandinghow nanomaterials can be used in a number of different ways, such as nanofiltration, micro-filtration,reverse osmosis and membrane distillation. This review aims to offer inspiration for further progress inthefield of water treatment and desalination employing polymeric nanocomposite membranes.

DFT and experimental study on adsorption of dyes on activated carbon prepared from apple leaves

Abdel-Aziz Mohamed Helmy,El-Ashtoukhy Elsayed Zakaria,Bassyouni Mohamed,Al-Hossainy Ahmed Farouk,Fawzy Eman M.,Abdel-Hamid Shereen M. S.,Zoromba Mohamed Shafick 한국탄소학회 2021 Carbon Letters Vol.31 No.5

This work reports utilization of apple leaves as a source of activated carbon. Activated carbon from apple leaves is prepared by two diferent methods, thermal activation where AC1 is obtained and chemical activation using H3PO4 and ZnCl2 where AC2 and AC3 are obtained, respectively. XRD analysis revealed that all types of prepared ACs have a semi-crystalline nature with a mean crystallite size of 13, 21.02, and 39.47 nm for AC1, AC2, and AC3, respectively. To identify the most suitable desorption temperature, the exothermic behavior was discovered for the three types of ACs by DSC. The exothermic onset temperatures are 340 °C, 200 °C, 400 °C, or AC1, AC2, and AC3, respectively. The point of zero charge for the three types of ACs is 8.6, 7.3, and 2.5 for AC1, AC2, and AC3, respectively. The BET surface area analysis data demonstrated that mesoporous structure was developed in AC1 and AC2, while a microporous structure was developed in AC3. Quantum chemical calculations for ACs is carried out using Density Functional Theory (DFT). Application of the prepared ACs in adsorption of basic dye C.I. base blue 47 is studied. The maximum removal efciency was 65.1%, 96% and 99% for AC1, AC2, and AC3, respectively under the infuence of diferent operating aspects. Adsorption data are modeled by Langmuir, Freundlich, and Temkin isotherms. The data revealed that adsorption of basic dye C.I. base blue 47 on AC1 follows Langmuir isotherm and adsorption on AC2 and AC3 follows Freundlich isotherm.

Synthesis, structural characterization, and optical properties of PVA/MnO2 materials for optoelectronics applications

Norah A. M. Alsaif,A. Atta,E. Abdeltwab,M. M. Abdel‑Hamid 한국고분자학회 2024 Macromolecular Research Vol.32 No.1

In this study, polyvinyl alcohol (PVA) was mixed with concentration of 5%, 7.5%, and 10% of manganese dioxide ( MnO2) to form PVA/MnO2 films using solution cast approach method. The X-ray diffraction (XRD) verified that the nanomaterials films were successfully fabricated. The scanning electron microscope (SEM) illustrates the uniform MnO2 dispersion within the PVA host matrix. Additionally, the influence of MnO2 on the optical properties is recorded. The refractive index (n0) is improved by adding MnO2, from 1.29 for PVA to 1.87 for PVA/5%MnO2 and 2.86 for PVA/10%MnO2. The PVA had a dispersion energy of 2.53 eV, while PVA with 5% MnO2 had 4.86 eV, PVA with 7.5% MnO2 had 5.74 eV, and PVA with 10%MnO2 had 7.12 eV. In addition, the oscillation energy E0 decreased from 3.79 for PVA to 1.94, 1.72, and 0.99 eV, respectively for PVA/5%MnO2, PVA/7.5%MnO2, and PVA/10%MnO2. It is evident from the data that the incorporation of MnO2 to the PVA polymer alters its optical properties. This proved the existence of strong interactions of PVA and MnO2 due to the modification of the PVA/MnO2 electronic structure. Moreover, the plasma frequency W p value increased from 0.79 × 1013 s− 1 for PVA to 2.06 × 1013 s− 1 for PVA/10%MnO2. These shifts in W p provided the polarization is modified for the PVA/MnO2. The results obtained in this study provide evidence of the advantages associated with the utilization of MnO2 nanoparticles as a filler of improved polymeric structures. These findings also propose the potential suitability of MnO2 nanoparticles for application in the field of optics and electronic devices.

Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3- triazol-1-yl)salicylhydrazones: revitalizing an old drug

Hajjaj H. M. Abdu-Allah,Bahaa G. M. Youssif,Mostafa H. Abdelrahman,Mohammed K. Abdel-Hamid,Rudraraju Srilakshmi Reshma,Perumal Yogeeswari,Tarek Aboul-Fadl,Dharmarajan Sriram 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.2

The antitubercular drug; para-aminosalicylicacid (PAS) was used as the core scaffold for the design of aseries of 1H-1,2,3-triazolylsalicylhydrazones upon couplingwith triazole and arylhydrazone moietis to furnish asingle molecular architecture. The obtained derivativeswere screened against Mycobacterium tuberculosis H37Rvrevealing good to high activity for the active compounds(MIC values of 0.39–1.5 lg/mL) compared to the marketeddrugs isoniazid, rifampicin and ethambutol. Moreover, themost active analogue N-(1-(4-chlorobenzyl)-2-oxoindolin-3-ylidene)-2-hydroxy-4-(4-phenyl-1H-1,2,3-triazol-1-yl)-benzohydrazide (20) was found to be ten-fold more potentthan PAS and equipotent to rifampicin (MIC 0.39 lg/mL),while exhibiting low cytotoxicity with a selectivity indexof[128. In addition, this compound was shown to beactive against persistent forms of mycobacteria comparableto standard drugs in nutrient starvation model. Accordingly,we introduce compound 20 as a valuable lead forfurther development. A 3D-QSAR study was also conductedto help in explaining the observed activity and toserve as a tool for further development.

Voltammetric Studies of Cu-Adriblastina Complex and Its Effect on ssDNA-Adriblastina Interaction at In Situ Mercury Film Electrode

D. Abd El-Hady,M. Ibrahim Abdel-Hamid,M. Mahmoud Seliem,N. Abo E-Maali 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.11

Adriblastina, a cancerostatic anthracycline antibiotic, causes considerable oxidative damage to DNA molecules. The interaction of this compound with DNA was investigated using Osteryoung square wave stripping voltammetry (OSWSV) and cyclic voltammetry (CV) at an in situ mercury film electrode. It was found that the equilibrium constant of the bonded oxidized form of the drug was 63 times bigger more important than that of the bonded reduced form. Copper forms 1 metal: 2 drug stoichiometry complex which is highly stable compared to ssDNA-drug interaction and consequently inhibited the drug biochemical damaging effects. Copper complex offered sub-nanogram determination of adriblastina in aqueous and urine media.

Estimation of Leucine Aminopeptidase and 5-Nucleotidase Increases Alpha-Fetoprotein Sensitivity in Human Hepatocellular Carcinoma Cases

Abouzied, Mekky Mohammed,Eltahir, Heba M.,Fawzy, Michael Atef,Abdel-Hamid, Nabil Mohie,Gerges, Amany Saber,El-Ibiari, Hesham Mohmoud,Nazmy, Maiiada Hassan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

Purpose: To find parameters that can increase alpha-fetoprotein (AFP) sensitivity and so help in accurate diagnosis and rapid management of hepatocullular carcinoma (HCC), as AFP has limited utility of distinguishing HCC from benign hepatic disorders for its high false-positive and false negative rates. Materials and Methods: Serum levels of AFP, 5'-nucleotidase enzyme activity (5-NU) and leucine aminopeptidase enzyme (LAP) activity were measured in 40 individuals. Results: LAP and 5'NU were elevated in HCC at p<0.001. Pearson correlation coefficients showed that changes in AFP exhibited positive correlation with both 5'-NU and LAP at (p<0.001). The complementary use of LAP only with AFP resulted in an increase in sensitivity of AFP from 75% to 90% in detecting HCC. The complementary use of both LAP and 5-NU with AFP resulted in an increased sensitivity of AFP in detecting HCC from 75% to 95%. Conclusions: LAP and 5-FU can be determined in HCC patients in combination with AFP to improve its sensitivity and decrease false negative results.

Nanoparticles of ZnO/Berberine complex contract COVID-19 and respiratory co-bacterial infection in addition to elimination of hydroxychloroquine toxicity

Ghareeb Doaa A.,Saleh Samar R.,Seadawy Mohamed G.,Nofal Mohammed S.,Abdulmalek Shaymaa A.,Hassan Salma. F.,Khedr Shaimaa M.,AbdElwahab Miral G.,Sobhy Ahmed A.,Abdel-Hamid Ali saber Ali,Yassin Abdelrah 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.6

Purpose A novel coronavirus (COVID-19) that has not been previously identified in humans and has no specific treatment has recently spread. Treatment trials using antiviral and immune-modulating drugs such as hydroxychloroquine (HCQ) were used to control this viral outbreak however several side effects have emerged. Berberine (BER) is an alkaloid that has been reported to reveal some pharmacological properties including antioxidant and antimicrobial activities. Additionally, Zinc oxide nanoparticles (ZnO-NPs) possess potent antioxidant and anti-inflammatory properties. Therefore, this study was undertaken to estimate the efficiency of both BER and synthetic ZnO/BER complex as an anti-COVID-19 therapy. Methods First, the ZnO/BER complex was prepared by the facile mixing method. Then in vitro studies on the two compounds were conducted including VeroE6 toxicity, anti-COVID-19 activity, determination of inhibitory activity towards papain-like proteinase (PL pro) and spike protein- and receptor- binding domain (RBD) as well as assessment of drug toxicity on RBCs. Results The results showed that ZnO/BER complex acts as an anti-COVID-19 by inhibiting spike protein binding with angiotensin-converting enzyme II (ACE II), PL pro activity, spike protein and E protein levels, and expression of both E-gene and RNA dependent RNA polymerase (RdRp) at a concentration lower than that of BER or ZnO-NPs alone. Furthermore, ZnO/BER complex had antioxidant and antimicrobial properties where it prevents the auto oxidation of 2,2-Diphenyl- 1-picrylhydrazyl (DPPH) and the culture of lower respiratory system bacteria that affected Covid 19 patients. The ZnO/BER complex prevented as well the HCQ cytotoxic effect on both RBC and WBC (in vitro) and hepatotoxicity, nephrotoxicity and anemia that occurred after HCQ long administration in vivo. Conclusion The ZnO/BER complex can be accounted as promising anti-COVID 19 candidate because it inhibited the virus entry, replication, and assembly. Furthermore, it could be used to treat a second bacterial infection that took place in hospitalized COVID 19 patients. Moreover, ZnO/BER complex was found to eliminate the toxicity of long-term administration of HCQ in vivo.