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Silvia Lakatošová,Katarína Janšáková,Jaroslava Babková,Gabriela Repiská,Ivan Belica,Mária Vidošovičová,Daniela Ostatníková 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.2
Objective Purpose of the study was to identify the relationship among actual plasmatic levels of steroid hormones and behavioral manifestations in boys with autism and to assess the genetic contribution to these manifestations.Methods 172 boys with autism under 10 years of age and 135 neurotypical boys attended the study. ADI-R and ADOS-2 were used to evaluate the core symptom severities. Problem behavior was assessed using BPI-01 questionnaire. Levels of testosterone, estradiol, dehydroepiandrosterone, dehydroepiandrosterone-sulfate and sex hormone binding globulin (SHBG) were measured in plasma of autistic boys. Three SNPs (in ESR1, SHBG, SRD5A2 genes) and one STR in AR gene (number of CAG repeats in first exon) were assessed. Hormonal levels and number of CAG repeats in AR gene were used for correlation analysis with behavioral measures. Genotype and allelic frequencies were compared among autistic and neurotypical boys.Results We found negative relationship among SHBG levels and restricted, repetitive behaviors (measured by ADOS-2) and positive relationship among actual testosterone levels and frequency of stereotyped behavior (measured by BPI-01).Conclusion Actual levels of SHBG and testosterone are related to severities of restricted and repetitive behaviors in boys with autism. Mechanisms of action of these hormones in brain require further investigation.
Z. Špitalský,D. Rástočná Illová,O. Žigo,M. Mičušík,Z. Nógellová,M. Procházka,A. Kleinová,M. Kováčová,I. Novák 한국섬유공학회 2019 Fibers and polymers Vol.20 No.8
Polyester (PES) fabrics were pre-treated with atmospheric discharge plasma, and the surface properties, chemicalcomposition, and physical changes on the surfaces of the PES fabrics were investigated. The hydrophobic recovery of theplasma-modified surface during aging of the PES fabrics treated with plasma was also investigated. The glycerin contactangles were determined along with the chemical composition changes in the PES fabric using X-ray photoelectronspectroscopy, Fourier-transform infrared spectroscopy, and iodometric analyses. The physical changes in the topography androughness of the plasma-modified PES were studied using scanning electron microscopy and nanoindentation. The relationbetween the hydrophilicity and hydroperoxide concentration on the surface of the plasma-treated PES fabrics was analyzedand the antibacterial behavior of the fabrics with respect to selected two bacterial strains was monitored.