메니에르병의 진단기준

Jose A. Lopez-Escamez,John Careyb,Won-Ho Chung,Joel A. Goebeld,Måns Magnusson,Marco Mandalà,David E. Newman-Tokerg,Michael Strupp,Mamoru Suzuki,Franco Trabalzini,Alexandre Bisdorff 대한평형의학회 2015 Research in Vestibular Science Vol.14 No.3

This paper presents diagnostic criteria for Ménierè’s disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology, the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery, and the Korean Balance Society. The classification includes two categories: definite Ménière's disease and probable Menière's disease. The diagnosis of definite Ménière's disease is based on clinical criteria and requires the observation of an episodic vertigo syndrome associated with low- to me-dium-frequency sensorineural hearing loss and fluctuating aural symptoms (hearing, tinnitus and/or fullness) in the affected ear. Duration of vertigo episodes is limited to a period between 20 minutes and 12 hours. Probable Ménierè's disease is a broader concept defined by episodic vestibular symptoms (vertigo or dizziness) associated with fluctuating aural symptoms occurring in a period from 20 minutes to 24 hours. Res Vestib Sci 2015;14(3):67-74

Effects of Combining Feed Grade Urea and a Slow-release Urea Product on Characteristics of Digestion, Microbial Protein Synthesis and Digestible Energy in Steers Fed Diets with Different Starch:ADF Ratios

Lopez-Soto, M.A.,Rivera-Mendez, C.R.,Aguilar-Hernandez, J.A.,Barreras, A.,Calderon-Cortes, J.F.,Plascencia, A.,Davila-Ramos, H.,Estrada-Angulo, A.,Valdes-Garcia, Y.S. Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.2

As a result of the cost of grains, the replacement of grains by co-products (i.e. DDGS) in feedlot diets is a common practice. This change produces diets that contain a lower amount of starch and greater amount of fibre. Hypothetically, combining feed grade urea (U) with slow release urea (Optigen) in this type of diet should elicit a better synchrony between starch (high-rate of digestion) and fibre (low-rate of digestion) promoting a better microbial protein synthesis and ruminal digestion with increasing the digestible energy of the diet. Four cannulated Holstein steers ($213{\pm}4$ kg) were used in a $4{\times}4$ Latin square design to examine the combination of Optigen and U in a finishing diet containing different starch:acid detergent fibre ratios (S:F) on the characteristics of digestive function. Three S:F ratios (3.0, 4.5, and 6.0) were tested using a combination of U (0.80%) and Optigen (1.0%). Additionally, a treatment of 4.5 S:F ratio with urea (0.80% in ration) as the sole source of non-protein nitrogen was used to compare the effect of urea combination at same S:F ratio. The S:F ratio of the diet was manipulated by replacing the corn grain by dried distillers grain with solubles and roughage. Urea combination did not affect ruminal pH. The S:F ratio did not affect ruminal pH at 0 and 2 h post-feeding but, at 4 and 6 h, the ruminal pH decreased as the S:F ratio increased (linear, p<0.05). Ruminal digestion of OM, starch and feed N were not affected by urea combination or S:F ratio. The urea combination did not affect ADF ruminal digestion. ADF ruminal digestion decreased linearly (p = 0.02) as the S:F ratio increased. Compared to the urea treatment (p<0.05) and within the urea combination treatment (quadratic, p<0.01), the flow of microbial nitrogen (MN) to the small intestine and ruminal microbial efficiency were greater for the urea combination at a S:F ratio of 4.5. Irrespective of the S:F ratio, the urea combination improved (2.8%, p = 0.02) postruminal N digestion. As S:F ratio increased, OM digestion increased, but ADF total tract digestion decreased. The combination of urea at 4.5 S:F improved (2%, p = 0.04) the digestible energy (DE) more than expected. Combining urea and Optigen resulted in positive effects on the MN flow and DE of the diet, but apparently these advantages are observed only when there is a certain proportion of starch:ADF in the diet.

Synaptic Vesicle Protein 2 (SV2) Isoforms

Bandala, Cindy,Miliar-Garcia, A.,Mejia-Barradas, C.M.,Anaya-Ruiz, M.,Luna-Arias, J.P.,Bazan-Mendez, C.I.,Gomez-Lopez, M.,Juarez-Mendez, S.,Lara-Padilla, E. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

New molecular markers of cancer had emerged with novel applications in cancer prevention and therapeutics, including for breast cancer of unknown causes, which has a high impact on the health of women worldwide. The purpose of this research was to detemine protein and mRNA expression of synaptic vesicle 2 (SV2) isoforms A, B and C in breast cancer cell lines. Cultured cell lines MDA-MB-231, SKBR3, T47D were lysed and their protein and mRNA expression analyzed by real-time PCR and western blot technique, respectively. SV2A, B proteins were identified in non-tumor (MCF-10A) and tumor cell lines (MDA-MB-231 and T47D) while SV2C only was found in the T47D cell line. Furthermore, the genomic expression was consistent with protein expression for a such cell line, but in MDA-MB-231 there was no SV2B genomic expression, and the SV2C mRNA and protein were not found in the non tumoral cell line. These findings suggest a possible cellular transdifferentiation to neural character in breast cancer, of possible relevance to cancer development, and point to possible use of SV2 as molecular marker and a vehicle for cancer treatment with botulinum toxin.

Influence of Ionophore Supplementation on Growth Performance, Dietary Energetics and Carcass Characteristics in Finishing Cattle during Period of Heat Stress

Barreras, A.,Castro-Perez, B.I.,Lopez-Soto, M.A.,Torrentera, N.G.,Montano, M.F.,Estrada-Angulo, A.,Rios, F.G.,Davila-Ramos, H.,Plascencia, A.,Zinn, R.A. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.11

Forty-eight crossbred heifers ($378.1{\pm}18$ kg) were used in a 56-d feeding trial (four pens per treatment in a randomised complete block design) to evaluate the influence of ionophore supplementation on growth performance, dietary energetics and carcass characteristics in finishing cattle during a period of heat stress. Heifers were fed a diet based on steam-flaked corn (2.22 Mcal $NE_m/kg$) with and without an ionophore. Treatments were: i) control, no ionophore; ii) 30 mg/kg monensin sodium (RUM30); iii) 20 mg/kg lasalocid sodium (BOV20), and iv) 30 mg/kg lasalocid sodium (BOV30). Both dry matter intake (DMI) and climatic variables were measured daily and the temperature humidity index (THI) was estimated. The maximum THI during the study averaged 93, while the minimum was 70 (THI average = $79.2{\pm}2.3$). Compared to controls, monensin supplementation did not influence average daily gain, the estimated NE value of the diet, or observed-to-expected DMI, but tended (p = 0.07) to increase (4.8%) gain to feed. Compared to controls, the group fed BOV30 increased ($p{\leq}0.03$) daily gain (11.8%), gain to feed (8.3%), net energy of the diet (5%), and observed-to-expected DMI (5.2%). Daily weight gain was greater (7.6%, p = 0.05) for heifers fed BOV30 than for heifers fed MON30. Otherwise, differences between the two treatments in DMI, gain to feed, and dietary NE were not statistically significant (p>0.11). Plotting weekly intakes versus THI, observed intake of controls was greater (p<0.05) at THI values ${\leq}77$ than ionophore groups. When THI values were greater than 79, DMI of control and MON30 were not different (p = 0.42), although less than that of groups fed lasalocid (p = 0.04). Variation in energy intake was lower (p>0.05) in the ionophores group (CV = 1.7%) than in the control group (CV = 4.5%). Inclusion of ionophores in the diet resulted in relatively minor changes in carcass characteristics. It is concluded that ionophore supplementation did not exacerbate the decline of DM intake in heat-stressed cattle fed a high-energy finishing diet; on the contrary, it stabilised feed intake and favoured feed efficiency. Ionophore supplementation reduced estimated maintenance coefficients around 10% in finishing cattle during a period of heat stress. This effect was greatest for heifers supplemented with 30 mg lasalocid/kg of diet.

Effects of Combining Feed Grade Urea and a Slow-release Urea Product on Performance, Dietary Energetics and Carcass Characteristics of Feedlot Lambs Fed Finishing Diets with Different Starch to Acid Detergent Fiber Ratios

Estrada-Angulo, A.,Lopez-Soto, M.A.,Rivera-Mendez, C.R.,Castro, B.I.,Rios, F.G.,Davila-Ramos, H.,Barreras, A.,Urias-Estrada, J.D.,Zinn, R.A.,Plascencia, A. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.12

Recent findings have shown that microbial nitrogen flow and digestible energy of diets are increased when urea is combined with a slow-release urea (SRU) in diets with a starch to acid detergent fibre ratio (S:F) 4:1. This affect is attributable to enhanced synchrony between ruminal N availability for microbial growth and carbohydrate degradation. To verify the magnitude of this effects on lamb performance, an experiment was conducted to evaluate the effects of combining urea and a SRU in diets containing S:F ratios of 3:1, 4:1, or 5:1 on performance, dietary energetics and carcass characteristics of finishing lambs. For that, 40 Pelibuey${\times}$Katahdin lambs ($36.65{\pm}3kg$) were assigned to one of five weight groupings in 20 pens (5 repetition/treatments). The S:F ratio in the diet was manipulated by partially replacing the corn grain and dried distiller's grain with solubles by forage (wheat straw) and soybean meal to reach S:F ratios of 3:1, 4:1 or 5:1. An additional treatment of 4:1 S:F ratio with 0.8% urea as the sole source of non-protein nitrogen was used as a reference for comparing the effect of urea combination vs. conventional urea at the same S:F ratio. There were no treatment effects on dry matter intake (DMI). Compared the urea combination vs urea at the same S:F ratio, urea combination increased (p<0.01) average daily gain (ADG, 18.3%), gain for feed (G:F, 9.5%), and apparent energy retention per unit DMI (8.2%). Irrespective of the S:F ratio, the urea combination improved the observed-to-expected dietary ratio and apparent retention per unit DMI was maximal (quadratic effect, $p{\leq}0.03$) at an S:F ratio of 4:1, while the conventional urea treatment did not modify the observed-to-expected net energy ratio nor the apparent retention per unit DMI at 4:1 S:F ratio. Urea combination group tended (3.8%, p = 0.08) to have heavier carcasses with no effects on the rest of carcass characteristics. As S:F ratio increased, ADG, G:F, dietary net energy, carcass weight, dressing percentage and longissimus thoracis (LM) area increased linearly ($p{\leq}0.02$). Combining urea and a slow-release urea product results in positive effects on growth performance and dietary energetics, but the best responses are apparently observed when there is a certain proportion (S:F ratio = 4:1) of starch to acid detergent fibre in the diet.

A STUDY OF THE PHOTOMETRIC VARIABILITY OF THE PECULIAR MAGNETIC WHITE DWARF WD 1953-011

Valyavin, G.,Antonyuk, K.,Plachinda, S.,Clark, D. M.,Wade, G. A.,Machado, Lester Fox,Alvarez, M.,Lopez, J. M.,Hiriart, D.,Han, Inwoo,Jeon, Young-Beom,Bagnulo, S.,Zharikov, S. V.,Zurita, C.,Mujica, R. IOP Publishing 2011 The Astrophysical journal Vol.734 No.1

<P>We present and interpret simultaneous new photometric and spectroscopic observations of the peculiar magnetic white dwarf WD 1953-011. The flux in the V-band filter and intensity of the Balmer spectral lines demonstrate variability with the rotation period of about 1.45 days. According to previous studies, this variability can be explained by the presence of a dark spot having a magnetic nature, analogous to a sunspot. Motivated by this idea, we examine possible physical relationships between the suggested dark spot and the strong-field magnetic structure (magnetic 'spot' or 'tube') recently identified on the surface of this star. Comparing the rotationally modulated flux with the variable spectral observables related to the magnetic 'spot,' we establish their correlation and therefore their physical relationship. Modeling the variable photometric flux assuming that it is associated with temperature variations in the stellar photosphere, we argue that the strong-field area and dark, low-temperature spot are comparable in size and located at the same latitudes, essentially overlapping each other with a possible slight longitudinal shift. In this paper, we also present a new, improved value of the star's rotational period and constrain the characteristics of the thermal inhomogeneity over the degenerate's surface.</P>

Bolted joints for single-layer structures: numerical analysis of the bending behaviour

A. Lopez- Arancibia,A.M. Altuna-Zugasti,H. Aizpurua Aldasoro,A. Pradera-Mallabiabarrena 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.3

This paper deals with a new designed joint system for single-layer spatial structures. As the stability of these structures is greatly influenced by the joint behaviour, the aim of this paper is the characterization of the joint response in bending through Finite Element Method (FEM) analysis using ABAQUS. The behaviour of the joints studied here was influenced by many geometrical factors, such as bolts and plate sizes, distance between bolts and end-plate thickness. The study comprised five models of joints with different values of those parameters. The numerical results were compared to the results of previous experimental tests and the agreement was good enough. The differences between the numerical and experimental initial stiffness are attributed to the simplifications introduced when modelling the bolt threads as well as the presence of residual stresses in the test specimens.

Numerical modelling for evaluating the TMD performance in an industrial chimney

Iban, A.L.,Brownjohn, J.M.W.,Belver, A.V.,Lopez-Reyes, P.M.,Koo, K. Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.17 No.3

A numerical technique for fluid-structure interaction, which is based on the finite element method (FEM) and computational fluid dynamics (CFD), was developed for application to an industrial chimney equipped with a pendulum tuned mass damper (TMD). In order to solve the structural problem, a one-dimensional beam model (Navier-Bernoulli) was considered and, for the dynamical problem, the standard second-order Newmark method was used. Navier-Stokes equations for incompressible flow are solved in several horizontal planes to determine the pressure in the boundary of the corresponding cross-section of the chimney. Forces per unit length were obtained by integrating the pressure and are introduced in the structure using standard FEM interpolation techniques. For the fluid problem, a fractional step scheme based on a second order pressure splitting has been used. In each fluid plane, the displacements have been taken into account considering an Arbitrary Lagrangian Eulerian approach. The stabilization of convection and diffusion terms is achieved by means of quasi-static orthogonal subscales. For each period of time, the fluid problem was solved and the geometry of the mesh of each fluid plane is updated according to the structure displacements. Using this technique, along-wind and across-wind effects have been properly explained. The method was applied to an industrial chimney in three scenarios (with or without TMD and for different damping values) and for two wind speeds, showing different responses.

Effect of Serve Execution on Serve Efficacy in Men`s and Women`s Beach Volleyball

( A. B. Lopez Martinez ),( J. M. Palao ) 한국스포츠정책과학원(구 한국스포츠개발원) 2009 International Journal of Applied Sports Sciences Vol.21 No.1

The purpose of this study was to assess the effect of serve technique and its manner of execution on the efficacy of the serve in beach volleyball according to gender. A total of 1073 serves from 25 sets of the 2003 World Championship and the 2004 Olympic Games were analyzed (508 serves from men`s games and 576 serves from women`s games). The variables studied were: type of serve (standing serve or jump serve), manner of execution (origin, destination, and distance), serve efficacy, result of the action, and gender. Descriptive and inferential analyses of the data were done (chi-square test and likelihood ratio) with a level of statistical significance set at p<0.05. The results show that for both genders: a) the jump serve involved a higher number of errors, points, and actions that limited the opponent; b) the jump serve and standing serve involved similar levels of efficacy; c) the serve directed toward the interference zone between receivers was the most effective; d) players used the jump serve and the standing serve; and e) no relationship was found between type of serve and result of the rally.

Validity of the estimates of oral cholera vaccine effectiveness derived from the test-negative design

Ali, M.,You, Y.A.,Sur, D.,Kanungo, S.,Kim, D.R.,Deen, J.,Lopez, A.L.,Wierzba, T.F.,Bhattacharya, S.K.,Clemens, J.D. Butterworths ; Elsevier Science Ltd 2016 Vaccine Vol.34 No.4

Background: The test-negative design (TND) has emerged as a simple method for evaluating vaccine effectiveness (VE). Its utility for evaluating oral cholera vaccine (OCV) effectiveness is unknown. We examined this method's validity in assessing OCV effectiveness by comparing the results of TND analyses with those of conventional cohort analyses. Methods: Randomized controlled trials of OCV were conducted in Matlab (Bangladesh) and Kolkata (India), and an observational cohort design was used in Zanzibar (Tanzania). For all three studies, VE using the TND was estimated from the odds ratio (OR) relating vaccination status to fecal test status (Vibrio cholerae O1 positive or negative) among diarrheal patients enrolled during surveillance (VE= (1-OR)x100%). In cohort analyses of these studies, we employed the Cox proportional hazard model for estimating VE (=1-hazard ratio)x100%). Results: OCV effectiveness estimates obtained using the TND (Matlab: 51%, 95% CI:37-62%; Kolkata: 67%, 95% CI:57-75%) were similar to the cohort analyses of these RCTs (Matlab: 52%, 95% CI:43-60% and Kolkata: 66%, 95% CI:55-74%). The TND VE estimate for the Zanzibar data was 94% (95% CI:84-98%) compared with 82% (95% CI:58-93%) in the cohort analysis. After adjusting for residual confounding in the cohort analysis of the Zanzibar study, using a bias indicator condition, we observed almost no difference in the two estimates. Conclusion: Our findings suggest that the TND is a valid approach for evaluating OCV effectiveness in routine vaccination programs.