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Novel upper gastrointestinal bleeding sensor capsule: a first human feasibility and safety trial
Lukas Bajer,Marvin Ryou,Christopher C. Thompson,Pavel Drastich 대한소화기내시경학회 2024 Clinical Endoscopy Vol.57 No.2
Background/Aims: Upper gastrointestinal bleeding (UGIB) is the most common GI condition requiring hospitalization. The present study aimed to evaluate the safety and feasibility of using the PillSense system (EnteraSense Ltd.), a novel diagnostic tool designed for the rapid in vivo detection of UGIB, in human volunteers. Methods: In the present study, 10 volunteers swallowed a PillSense capsule, followed by 2 servings of an autologous blood preparation. Participants were monitored for capsule passage, overall tolerability of the procedure, and adverse events. Results: The procedure was completed per the protocol established in the present study in 9/10 cases. In 9 of the subjects, after capsule ingestion, the device indicated the absence of blood with sensor output values of 1. After the ingestion of the first blood mixture, the sensor outputs of all devices increased to a range from 2.8 to 4, indicating that each sensor capsule detected blood. The sensor output remained within that range after the ingestion of the second mixture; however, in one case, the baseline capsule signal was positive, because of a preexisting condition. The passage of the capsule was verified in all patients, and no adverse events were reported. Conclusions: The first trial of the PillSense system in human subjects demonstrated the feasibility, safety, and tolerability of utilizing this product as a novel, noninvasive, and easy-to-use triage tool for the diagnosis of patients suspected of having UGIB.
Local Signs and Symptoms in Spontaneous Cervical Artery Dissection: A Single Centre Cohort Study
Lukas Mayer,Christian Boehme,Thomas Toell,Benjamin Dejakum,Johann Willeit,Christoph Schmidauer,Klaus Berek,Christian Siedentopf,Elke Ruth Gizewski,Gudrun Ratzinger,Stefan Kiechl,Michael Knoflach 대한뇌졸중학회 2019 Journal of stroke Vol.21 No.1
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Vocational Education of Skilled Workers for Industrial Chemistry, Germany - Switzerland
Lukas Sigrist 대한공업교육학회 1982 대한공업교육학회지 Vol.7 No.2
숙련 기술자들의 수준에서 두 가지 직업이 공업화학을 위해 구분된다. 하나는 화학실험실 작업으로 규정되고, 다른 하나는 제조과정으로 규정된다. 직업교육은 도제살이에 의해서 행해진다. 즉, 다시말하면 실재 작업장소에서 실재훈련이나, 실업계 학교들에서 행해지는 이론적이고 일반적인 교육을 말한다. 직업교육은 법률과 규칙으로 규정되고 있다. On the level of skilled workers, two vocations are distinguished for industrial chemistry, one oriented to the chemical laboratory work, the other to the manufacturing process. The vocational education is done by apprenticeship, i.e. the practical training on the real working place, the theoretical and general education at vocatonal schools. The vocational education is legislated by laws and regulations.
Lukas Hefermehl,Karolin Bossert,Venkat M. Ramakrishnan,Burkhardt Seifert,Kurt Lehmann 대한배뇨장애요실금학회 2018 International Neurourology Journal Vol.22 No.2
Purpose: This study aims to objectively characterize the effect of successful nerve sparing (NS) during radical prostatectomy (RP) on postoperative urinary continence (UC) using International Index of Erectile Function (IIEF)-scores and a previously described Expanded Prostate Cancer Index Composite (EPIC) score cutoff value (COV) for UC. Several notable studies on this topic present conflicting outcomes. This is largely due to a lack of clear definitions and consensus regarding preserved erectile function (EF) and UC. Methods: This study is comprised of all patients who underwent RP at the Kantonsspital Baden, Switzerland, between 2004 and 2013. Patients completed self-assessment questionnaires for UC (EPIC) and EF (IIEF) pre- and postoperatively (3, 6, 9, 12, 18, and 24 months; yearly thereafter). We used a previously described EPIC subscore COV, with “satisfactory continence” signified by a score >85. Statistical analysis was performed using Kaplan-Meier and Cox regression analyses for “surgeon-” and “IIEF-defined” NS definitions. Results: Of 236 men with a median age of 63 years (interquartile range [IQR], 59–66 years) and median follow-up time of 48 months (IQR, 30–78 months), 176 underwent unilateral (n=33) or bilateral (n=143) NS RP. Fifty-four underwent non-NS (NNS) RP. Kaplan-Meier analyses identified the following risk factors for UC: age, prostate volume, cancer risk group, and NS status. In surgeon-defined NS RP cases, multivariate analysis for regaining continence demonstrated no significant difference (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.48–1.25; P=0.3). With successful IIEF-defined NS RPs, regression analysis demonstrated no significant difference (HR, 0.89; 95% CI, 0.59–1.35; P=0.58). Conclusions: In our population, analysis and comparison of surgeon- and IIEF-defined NS and NNS cohorts revealed that NS RP did not improve postoperative UC. The conservation of UC alone should not motivate surgeons or patients to pursue NS RP.
Lukas de Lorent,Agorastos Agorastos,Alexander Yassouridis,Michael Kellner,Christoph Muhtz 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.4
Although acupuncture treatment is increasingly in demand among psychiatric patients, to date no studies have investigated the effectiveness of auricular acupuncture (AA) in treating anxiety disorders or major depressive disorder. Thus, this study aimed to compare the effectiveness of AA versus progressive muscle relaxation (PMR), a standardized and accepted relaxation method. We examined 162 patients with a primary diagnosis of anxiety disorder or major depressive disorder, and each patient chose between treatment with AA, executed according to the National Acupuncture Detoxification Association protocol, and treatment with PMR. Each group had treatments twice a week for 4 weeks. Before and after treatment, each participant rated four items on a visual analog scale: anxiety, tension, anger/aggression, and mood. Statistical analyses were performed with the original visual analog scale scores and the Change-Intensity Index, an appropriate indicator of the difference between two values of a variable. Our results show that treatment with AA significantly decreased tension, anxiety, and anger/aggression throughout the 4 weeks, but did not elevate mood. Between AA and PMR, no statistically significant differences were found at any time. Thus, we suggest that both AA and PMR may be useful, equally-effective additional interventions in the treatment of the above-mentioned disorders.