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Franciele Donato,Carlos Borges Filho,Renata Giacomeli,Elza Eliza Teno´rio Alvater,Lucian Del Fabbro,Michele da Silva Antunes,Marcelo Gomes de Gomes,Andre´ Tiago Rossito Goes,Leandro Cattelan Souza,Sil 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.7
The administration of hesperidin elicits an antidepressant-like effect in mice by a mechanism dependent on an interaction with the l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway, whose stimulation is associated with the activation of potassium (K+ ) channels. Thus, this study investigated the involvement of different types of K+ channels in the antidepressant-like effect of hesperidin in the mice tail suspension test (TST). The intracerebroventricular administration of tetraethylammonium (TEA, a nonspecific blocker of K+ channels), glibenclamide (an ATP-sensitive K+ channel blocker), charybdotoxin (a large- and intermediate-conductance calcium-activated K+ channel blocker) or apamin (a small-conductance calcium-activated K+ channel blocker) combined with a subeffective dose of hesperidin (0.01 mg/kg, intraperitoneally [i.p.]) was able to produce a synergistic antidepressant-like effect in the mice TST. Moreover, the antidepressant-like effect elicited by an effective dose of hesperidin (0.3 mg/kg, i.p.) in TST was abolished by the treatment of mice with pharmacological compounds K+ channel openers (cromakalim and minoxidil). Results showed that the antidepressantlike effect of hesperidin in TST may involve, at least in part, the modulation of neuronal excitability through inhibition of K+ channels and may act through a mechanism dependent on the inhibition of l-arginine-NO pathway.