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P206 : Integral hair lipid based barrier in human hair follicle
( Long Quan Pi ),( Sungjoo Tommy Hwang ),( Won Soo Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Integral hair lipid (IHL) plays an important role in all compartments of hair and skin substructures and also in involvement of hair development and function. Objectives: In this study, we described the IHL based barrier in human hair follicle according to the hair keratinization. Methods: The techniques of immunofluorescence and of transmission electron microscopy were performed to observe the ultrastructure of the hair lipid. Hair follicles were cut and observed longitudinally along the hair axis. For revealing IHL with electron microscopy, Lee’s fixative, composed of OsO4 and RuO4 was designed and used. Results: Ultrastructure of anagen hair follicle at the level where Henle layers are keratinizing, showed the intercellular lipid layer (IL) and lamellar structure (LS). Ultrastructure of anagen hair follicle at the level where the inner root sheath (IRS) is completely keratinized showed multiple LS and lamellar granules (LG). Multitudes of LS and IL are observed between the keratinized cells in IRS. Conclusion: The IHL in the hair follicle may be regarded as hair barrier to be similar to the epidermal lipid layer functioning as skin barrier.
Long-quan Pi,이원수,민성희 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2
Effects of hot water extracts of oriental melon leaves (OML) on promotion of hair growth were investigated. Topical OML extract administration for hair regeneration was investigated using an in vivo model with C57BL/6 mice. Effects of OML extracts on the human hair growth were investigated using a hair follicle organ culture. OML extracts induced a shortened telogen to anagen conversion and promoted hair growth in the C57BL/6 mouse model. Culture of human hair follicles in the presence of OML extracts for 8 days promoted hair growth and prolonged the anagen duration due to induction of hair follicle cell proliferation in the bulb region. OML extracts exert a hair growth promotion effect and, therefore, can be used as a therapeutic agent for prevention of hair loss.