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RISS 인기검색어
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- 저자 : Liu Yanghui (검색결과 5 건)
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Local estimation for longitudinal semiparametric varying-coefficient partially linear model
Yanghui Liu,Riquan Zhang,Hongmei Lin 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.2
In this paper, estimation for the semiparametric varying coefficient partially linear model with longitudinal data is investigated. We propose an intuitive procedure to estimate the regression function and the covariance structure simultaneously based on the modified Cholesky decomposition and profile least square technique. The asymptotic normality of the resulting estimators is further derived. Moreover, we develop a variable selection procedure to select significant parameter components for the model within the framework of profile least square estimate. A simulation study is conducted to illustrate the finitesample performance of the estimation and variable selection procedures. Finally, the proposed method is applied to analyze a set of chronic kidney disease (CKD) progression data in a study of the relationship between glomerular filtration rate (GFR) and the risk factors among CKD patients.
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Robust estimation for a general functional single index model via quantile regression
Zhu Hanbing,Zhang Riquan,Liu Yanghui,Ding Hui 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.4
This paper studies the estimation of a general functional single index model, in which the conditional distribution of the response depends on the functional predictor via a functional single index structure. We find that the slope function can be estimated consistently by the estimation obtained by fitting a misspecified functional linear quantile regression model under some mild conditions. We first obtain a consistent estimator of the slope function using functional linear quantile regression based on functional principal component analysis, and then employ a local linear regression technique to estimate the conditional quantile function and establish the asymptotic normality of the resulting estimator for it. The finite sample performance of the proposed estimation method is studied in Monte Carlo simulations, and is illustrated by an application to a real dataset.
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Identification of a mimotope of an infectious bronchitis virus S1 protein
Jingming Zhou,Jianan Li,Yanghui Li,Hongliang Liu,Yanhua Qi,Aiping Wang 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.4
The S1 protein of the infectious bronchitis virus (IBV) is a major structural protein that induces the production of the virus-neutralization antibodies. The monoclonal antibody against the IBV M41 S1 protein was used as a target for biopanning. After three rounds of biopanning, randomly selected phages bound to the monoclonal antibody. Sequence analysis showed that the dominant sequence was SFYDFEMQGFFI. Indirect competitive enzyme-linked immunosorbent assay showed that SFYDFEMQGFFI is a mimotope of the S1 protein that was predicted by PepSurf. The mimotope may provide information for further structural and functional analyses of the S1 protein.
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Yang, Hui,Liu, Yu-Hui,Xu, Liang,Liu, Li-Heng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Background: The aim of this study was to explore the efficacy and adverse reactions of CT-guided radioactive 125I-seed implantation treatment combined with chemotherapy for platinum-resistant recurrent ovarian carcinoma. Materials and Methods: From September 2010 to December 2012, 23 patients with platinum-resistant recurrent ovarian carcinoma were enrolled. All the patients refused, could not bear, or were not suitable for surgery. They all had no more than 3 lesions, which were detected and could also be measured by CT. All were clarified as single-lesion or multiple-lesion groups. A total of 41 lesions underwent implantation of from 8 to 106 125I seeds (median=43). Multi-plane implanting was adopted and 125I-seeds of (0.4-0.7)mCi were placed at intervals of (0.5-1.0) cm. After implantation treatment, all patients underwent 4 cycles of chemotherapy with gemcitabine $800mg/m^2$ (days 1, 8 and 15). Results: The outcome was evaluated with CT 3 weeks and every 3 months after implantation treatment. After 6 months, the volume of 32 out of 41 lesions (78.0%) was reduced at least 30%, within which 9 lesions completely disappeared(22.0%). Complete response was observed in 7 cases (30.4%), with a partial response in 4 cases (17.4%), 4 cases stable(17.4%)and 8 cases showing progression (34.8%). The total clinical remission rate was 47.8% (11/23). The clinical remission rate was 77.8% (7/9) in the single-lesion group and 28.6% (4/14) in the multiple-lesion group with a significant difference between the two(P=0.036). The common side effects observed were mild gastrointestinal reactions. Conclusions: 125I-seed implantation combined with chemotherapy applies an effective way in the treatment of platinum-resistant recurrent ovarian epithelial carcinoma with the advantages of high local control rates, good short-term effects, little trauma and less side effects.
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Involvement of Orai1 in tunicamycin-induced endothelial dysfunction
Yang, Hui,Xue, Yumei,Kuang, Sujuan,Zhang, Mengzhen,Chen, Jinghui,Liu, Lin,Shan, Zhixin,Lin, Qiuxiong,Li, Xiaohong,Yang, Min,Zhou, Hui,Rao, Fang,Deng, Chunyu The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
Endoplasmic reticulum (ER) stress is mediated by disturbance of $Ca^{2+}$ homeostasis. The store-operated calcium (SOC) channel is the primary $Ca^{2+}$ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on $Ca^{2+}$ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular $Ca^{2+}$ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.
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