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RISS 인기검색어
- 검색키워드
- 저자 : Linyong Sun (검색결과 2 건)
- 무료
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- 유료
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The Expression of Aldehyde Dehydrogenase Family in Breast Cancer
Yan Qiu,Tianjie Pu,Li Li,Fei Cheng,Changli Lu,Linyong Sun,Xiao Teng,Feng Ye,Hong Bu 한국유방암학회 2014 Journal of breast cancer Vol.17 No.1
Purpose: It is widely accepted that aldehyde dehydrogenase(ALDH) activity is a signature of breast cancer stem cells, andhigh activity has been reported to be associated with poor clinicaloutcome. The aim of this study was to assess the expressionof members of the ALDH family of isozymes in breast cancer tissuesand to evaluate the implications of the results. Methods: Weanalyzed paraffin-embedded tumor tissue from 160 patients withbreast cancer. Immunohistochemistry (IHC) staining was performedon the slides using antibodies against different ALDHfamily members. We collated the IHC results with patient clinicalcharacteristics and determined their prognostic value. In addition,we analyzed normal, hyperplastic, and carcinomatous tissues insitu to check their ALDH distributions. Results: All the testedALDH members were detected in the various tissue types, but atdifferent levels. Only ALDH 1A3 was found to be significantly associatedwith distant metastasis (p=0.001), disease-free survival(p<0.001), and overall survival (p<0.001). Conclusion: The levelof ALDH 1A3 in breast cancer tissue is a predictive marker of apoor clinical outcome.
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The Presence of EpCAM-/CD49f+ Cells in Breast Cancer Is Associated with a Poor Clinical Outcome
Feng Ye,Yan Qiu,Li Li,Libo Yang,Fei Cheng,Hongying Zhang,Bing Wei,Zhang Zhang,Linyong Sun,Hong Bu 한국유방암학회 2015 Journal of breast cancer Vol.18 No.3
Purpose: It is well established that breast cancer stem cells (BCSCs) play an essential role in tumor invasion for both local and distant metastasis. The aim of this study was to establish whether BCSCs could act as a prognostic and clinical marker. Methods: We analyzed tumor tissues from 161 breast cancer patients. Dual immunohistochemistry and immunofluorescence were performed on all the slides, and we analyzed the relationship between EpCAM–/CD49f+ tumor cells and key clinical and prognostic factors. Results: Univariate survival analysis using the Kaplan-Meier method showed that the presence of EpCAM–/ CD49f+ tumor cells in breast cancer was significantly associated with shorter disease-free survival (DFS) and overall survival (OS). Multivariate analysis showed that the presence of EpCAM–/ CD49f+ cells was associated with shorter DFS (p=0.010; hazard ratio [HR], 2.070) and OS (p=0.002; HR, 3.235). Tumors containing EpCAM–/CD49f+ cells were also more likely to metastasize after initial surgery (p=0.048). Conclusion: Our study suggests that breast tumors containing EpCAM–/CD49f+ cells are more likely to undergo distant metastasis after initial surgery and are associated with a shorter DFS and OS.
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