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- 검색키워드
- 저자 : Lingarkar Silpavathi (검색결과 2 건)
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Lingarkar Silpavathi,Mukesh Kumar Das,Debajyoti Das 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.1
Ardisia solanacea is a well-known herb with a significant medicinal value. Traditionally, the plant extracts have commonly been used as an immunomodulator, antimicrobial, thrombolytic, anthelminthic, and cytotoxic agent in India. The objective of this study was to assess the in-vivo antiarthritic potential of A. solanacea in the adjuvant-induced arthritic rat model. The rats were divided into nine groups (n = 6). They were administered with complete freunds adjuvant (CFA) in the right hind paw and treated with different doses (250 mg/kg, 500 mg/kg) of the leaf extract orally from day one to day 21st. The standard group was treated with 10 mg/kg body weight of diclofenac sodium. Throughout the treatment, we monitored the differences in paw edema, body weight (BW), and arthritis index in different groups of animals. Besides, we also have evaluated the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, C-reactive protein, rheumatoid factor (RF), and hematology. Further, we have assessed the severity of arthritis through radiography and histopathology of ankle joints. In addition, we also have studied liver and kidney histology. The arthritic symptoms were subsided significantly (p < 0.01) in the test extract treated groups at a higher dose. We also observed a downregulation of cytokines in the ASM and ASW treated group compared to the negative control. Furthermore, radiography and histopathology revealed improved prognosis in ASM and ASW administered groups. Methanolic and aqueous extract of Ardisia solanacea exhibited potential antiarthritic effect against CFA-induced arthritic rats.
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Das Mukesh Kumar,Silpavathi Lingarkar,Das Debajyoti 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.3
Ulva fasciataDelile, a marine macroalga is abundantly available on the intertidal rocky surface of Visakhapatnam coasts, India, during summer. The algae belong to family Ulvaceae and division Chlorophyta is glossy green in color. Being a prolific source of bioactive compounds, this thallus allured an unprecedented concern of the author to study its anatomy, histo-chemistry and in-vivo anticancer property. Primarily, the morpho-anatomy and histo-chemistry of the thallus were studied to identify correct species and locate the active phytoconstituents in the cell saps. Besides, the in-vivo anticancer activity of the methanolic algal extract (MAE) was studied on Ehrlich’s ascites carcinoma (EAC) xenografted mice. The light microscopy of the thallus divulged very thick cuticularized layers in the sectional view. A fat middle lamella was observed in between two layers of vertically oblong palisade cells. The histo-chemistry revealed the presence of starch grains, calcium oxalate crystals, tannin, protein,and lipids as major cell inclusions. The extract exhibited a profound inhibitory activity on EAC xenografted mice (p˂0.001). Increase in mean survival time (p˂0.001) and restoration of the hematological parameter in drug-treated rodents were clear indicators of anticancer potential of the MAE. It was espoused by the results garnered from various parameters like reduced ascites tumor volume, declined peritoneal cavity size, the percentage increase in life span (%ILS), declined cell viability andperitoneal angiogenesis, and the improved result obtained from histopathology of vital organs.
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