Poster Session : The functional analysis of NLCAM during gastrulation and neurogenesis

( Su Hyun Kim ),( Hyung Seok KIM ),( Tae Lin Huh ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

Beneficial effects of the traditional medicine Igongsan and its constituent ergosterol on dextran sulfate sodium-induced colitis in mice

KIM, SU-JIN,SHIN, HYUN-JI,LEE, GEUN-HYUK,KIM, DAE-SEUNG,KIM, HYE-LIN,PARK, JINBONG,JUNG, YUNU,YOUN, DONG-HYUN,KANG, JONGWOOK,HONG, SEUNG-HEON,UM, JAE-YOUNG SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3

<P>Ulcerative colitis (UC) is a type of inflammatory bowel disease and is considered a chronic gastrointestinal disorder. Igongsan (IGS) is a Korean herbal medicine, which has been used to treat digestive disorders. However, the ameliorative effect and molecular mechanisms of IGS in intestinal inflammation have not yet been studied in detail. The present study aimed to investigate the protective effects of IGS and its constituent, ergosterol, in a mouse model of dextran sulfate sodium (DSS)?induced colitis. Colitis was induced in mice by supplementing their drinking water with 5% (w/v) DSS for 7 days. The effects of IGS were then determined on DSS?induced clinical signs of colitis, including weight loss, colon shortening, diarrhea and obscure/gross bleeding. In addition, the effects of IGS were determined on the expression levels of inflammation?associated genes in the colon tissue of DSS?treated mice. The results of the present study demonstrated that mice treated with DSS exhibited marked clinical symptoms, including weight loss and reduced colon length. Treatment with IGS attenuated these symptoms and also suppressed the expression levels of tumor necrosis factor?α and interleukin?6, as well as the expression of cyclooxygenase?2 in the colon tissue of DSS?treated mice. IGS also reduced the activation of the transcription factor nuclear factor?κB p65 in the colon tissue of DSS?treated mice. In addition, ergosterol was shown to attenuate the DSS?induced clinical symptoms of colitis in mice. In conclusion, the present study provided experimental evidence that IGS may be a useful therapeutic drug for patients with UC.</P>

지식경영

김인수(Lin Su Kim) 한국경영학회 1999 經營學硏究 Vol.28 No.3

Knowledge management has recently emerged as an appealing subject in management literature. Although its history is short, it can benefit greatly from the long history of other related disciplines in building its theories. Innovation, organizational learning, knowledge creation, organizational capability buiding, technology transfer and network, information technology, organizational behavior, and intellectual capital are the disciplines that have accumulated theories related to knowledge management. This paper first presents a conceptual framework that integrates three dimensions: the characteristics of knowledge (tacit and explicit), knowledge process(acquisition, creation, diffusion, storing, measurement, and application of knowledge), and the unit of analysis (individual, organization, sector, and nation). The conceptual framework produces a number of cells that need to be filled by new theories in order to understand knowledge management better. It then reviews existing theories available in the related disciplines that may be used as building blocks in constructing new theories for these cells. Finally, based on the theories available in other disciplines, the paper suggests a set of future research directions for knowledge management at the level of individual, organization, sector, and nation.

조직공학적 연골재생을 위한 In Vivo 환경에서의 케라틴/PLGA 지지체의 효과

정수현 ( Su Hyun Jung ),김순희 ( Soon Hee Kim ),양재찬 ( Jae Chan Yang ),홍현혜 ( Hyun Hye Hong ),김혜린 ( Hye Lin Kim ),김원 ( Won Kim ),손영숙 ( Young Sook Son ),( Sang Jin Lee ),( Mark Van Dyke ),( James J Yoo ),이종문 ( 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1

Articular cartilage that is difficult to recovery when damaged needs to tissue engineering. keratin are the intermediate filament proteins that form a dense meshwork of filaments throughout the of cells and generally expressed in particular pairs of type I and type II keratin proteins in a-specific and cellular differentiation-specific manner. In this study, we are developing an alternative approach that consists of generating chondrocytes anchored to poly(L-lactide-co-glycolide)(PLGA) scaffolds impregnated keratin(keratin/PLGA) using tissue-engineering principles. We prepared PLGA and keratin/PLGA scaffolds using solvent casting/salt leaching method. Chondrocytes were isolated from the articular cartilage of New Zealand white rabbit and cultured With DMEM/Ham`s F-12 supplemented with 10 % FBS, 1 % penicillin streptomycin, 200 mM L-glutamin, 50 ?g/ml of ascorbic acid and 15 mM HEPES buffer 1M. After 2weeks of cell seeding, we implanted keratin /PLGA scaffolds on the back of nude mice. Morphological observation, histology, biological assay for collagen and sGAG, and PCR were performed at each time point 1, 2, 3 and 6 weeks. The cell viability and the quantity of collagen and sGAG were better keratin/PLGA scaffolds than PLGA scaffolds. Specific mRNA, type II and type I collagen, for chondrocyte expressed significantly highly in keratin/PLGA scaffold. keratin/PLGA scaffold promotes in vivo chondrocyte of rabbit articular chondrocytes. This study suggests that keratin/PLGA scaffold may serve as a potential cell delivery vehicle and a structural basis for in vivo tissue engineered articular cartilage.

조선 후기 민가 정원 쌍산재의 조영과 변화 과정

김서린 ( Kim Seo-lin ),성종상 ( Sung Jong-sang ),김희수 ( Kim Hee-su ),최유나 ( Cui Yu-na ),정진아 ( Jung Jin-ah ),조성아 ( Cho Seong-ah ) 한국전통조경학회(구 한국정원학회) 2021 한국전통조경학회지 Vol.39 No.2

쌍산재는 1800년대 중반에 조성된 민가 정원이다. 북으로 지리산 줄기를 등지고 남으로는 섬진강을 내려다보는, 전형적인 한국의 배산임수 형국을 이루는 터에 입지하고 있다. 조성된 이후 6대를 거쳐 오면서도 정원에 큰 변화 없이 조선 후기 민가 정원의 면모를 잘 간직하고 있는 정원이다. 본 연구는 현장 조사와 인터뷰, 작정자의 유고집과 편액, 주련의 내용 분석을 통해 역사 정원으로서 쌍산재의 변화하는 경관에 대해 고찰하였다. 완만한 구릉지에 위치한 쌍산재는 크게 내원과 외원으로 분류되며, 내원은 진입 공간, 주거 공간, 전이 공간, 후원 영역으로 구분된다. 후원은 서당채와 그 정원, 경암당 등으로 구성되며 외원인 사도저수지 영역으로 이어 진다. 쌍산재의 특징적인 식생 경관은 13,000㎡의 죽녹차밭과 잔디밭을 가로지르는 길 양쪽에 열식된 모란과 작약, 그리고 동백이나 사철나무의 휜 가지가 보여주는 액경, 마지막으로 탱자나무와 대나무로 이뤄진 생울타리를 꼽을 수 있다. 쌍산재는 지형과 원식생(原植生)을 고려한 공간 구성과 배치가 돋보인다. 주요 건축물은 후손들이 선대의 아호를 따 이름 지었는데, 벼슬길에 오르지 않고, 은일하며 후학을 양성하고자 했던 선대 조영자들의 철학관이 묻어난다. 오주석 선생이 세운 입석과 하얀 경계석은 쌍산재만의 독특한 정원 시설이다. 현 소유자가 가족들과 방문객의 편의를 위해 조성한 석상, 돌의자, 수영장 등 또한 특징적인 경관을 연출한다. 쌍산재는 거주자에게는 살림집이자 친우들과의 교류의 장, 수신(修身)과 은일(隱逸)의 장이었으며, 아이들에게는 배움의 장이었다면 현재는 여러 사람들이 힐링할 수 있는 민가 정원으로서 성격을 갖는다. 200여 년의 시간이 흐르는 동안 쌍산재의 내외원의 경관은 일부 변화를 겪었다. 이렇듯 변화하는 속성을 가진 역사 정원의 특성은 살아 있는 유산으로서 정원 고유의 속성으로 인식할 필요가 있다. 본 연구는 쌍산재를 조경학 관점에서 다룬 최초의 연구로서, 현존하는 조선조 민가 정원이 매우 적다는 점에서 앞으로 보다 심층적인 연구가 필요할 것으로 본다. 아울러 현재 점차 관심이 높아지고 있는 정원 관광 상품으로서 역사 정원의 가치와 효용을 가늠해 볼 여지도 있을 것으로 판단된다. Ssangsanjae was created in the mid-1800s, It is located at Jiri Mountain to the north and the Seomjin River to the south. This garden has not changed much even though it has passed through the sixth generation since its creation, so it still retains the features of a private garden in the late Joseon Dynasty. This study focused on the changing landscape of Ssangsanjae as a historical garden; through field surveys, interviews and analysis of builder's collection, boards and couplets. Ssangsanjae is largely classified into inner and outer gardens, and the inner is divided into an entry space, a residential space, and a backyard. The backyard consists of Seodangchae, it's garden, Gyeongamdang, and swimming pool, and is connected to the Sado Reservoir area, which is the outer garden. The distinct vegetation landscape of Ssangsanjae are a 13,000㎡ bamboo and green tea field, Peony(Paeonia suffruticosa Andr. and Paeonia lactiflora var. trichocarpa(Bunge) Stern) planted on both sides of the road that crosses the lawn, the view through a frame(額景) shown by the twisted branches of Camellia and Evergreen spindletree, and a fence made of Trifolia Orange(Poncirus trifoliata) and Bamboo. Ssangsanjae stands out for its spatial composition and arrangement in consideration of the topography and native vegetation. The main building was named by the descendants based on the predecessor's Aho(pseudonym), and it is the philosophical view of the predecessors who tried to cultivate the younger students without going up on the road. The standing stone and white boundary stone built by Mr. Oh Ju Seok are Ssangsanjae's unique gardening facilities. The stone chairs, and swimming pool which were created by the current owner for the convenience of families and visitors also make a distinctive landscape. Ssangsanjae, for residents, was a place for living, exchanging friendships, training himself and seculusion, for children was a place for learning, but now is ‘the private garden’ where many people can heal themselves. Over the 200 years, the landscape of Ssangsanjae's inner and outer gardens experienced large and small changes. As such, it is necessary to recognize the historical gardens with changing properties as a living heritage. This study is significant in that, as the first study to approach Ssangsanjae in the view of landscape research, it provides basic data on Ssangsanjae as a destination of garden tourism.

PLGA의 염증완화에 대한 피브린의 효과

김수진(Su Jin Kim),홍현혜(Hyun Hye Hong),김순희(Soon Hee Kim),김혜린(Hye Lin Kim),김세호(Se Ho Kim),강길선(Gil Son Khang) 한국고분자학회 2010 폴리머 Vol.34 No.1

원주 매지농악 진풀이와 김백봉 <선의 유동> 구도 변화 연구

이수린 ( Su-lin Lee ),김경회 ( Kyung-hoi Kim ) 대한무용학회 2017 대한무용학회논문집 Vol.75 No.4

The purpose of this research is to examine Wonju Maeji Nong-ak having a variety of unique jinpulis and Kim Baik Bong`s < Flow of Line > showing a number of changeable dance composition in order to find the way of utilising the composition changes for Korean traditional dance. The jinpuli of Wonju Maeji Nong-ak shows 28 composition changes: 13 curve structures and 12 straight linear structures and 3 compound structures. < Flow of Line > shows 41 composition changes: 23 curve structures, 9 straight linear structures and 9 compound structures. Each work has distinctive composition changes and also has 11 similar composition structures.

알긴산을 첨가한 수리미 혼합물의 응고에 미치는 칼슘의 영향

김수룡 ( Su-ryong Kim ),한현수 ( Hyeon-su Han ),박예린 ( Ye-lin Park ),강유석 ( Yoo-seok Kang ),박정철 ( Jeong-cheol Park ),서훈서 ( Hun-seo Seo ),최예희 ( Ye-hui Choi ),김수형 ( Su-hyeong Kim ),정소미 ( So-mi Jeong ),강우신 ( Woo 한국수산과학회(구 한국수산학회) 2021 한국수산과학회지 Vol.54 No.2

In this study, the possibility of use as a cartridge for 3D printing was confirmed by adding calcium to the alginic acid-added surimi mixture. The Alaska pollack Gadus chalcogrammus surimi added with alginic acid was immersed in a calcium solution (1 M calcium carbonate, 1 M calcium chloride, 1 M calcium sulfate, and 0.1 M calcium lactate) to evaluate the physical properties, color differences, and sensory properties of Alaska pollack surimi according to calcium types. As the results, in the case of surimi paste to which 1 M calcium carbonate was added, physical properties were weaker than that of 1 M calcium chloride, but gelation was appropriate and sensory properties was excellent. Addition of 1 M calcium chloride has the best physical properties, but it has a problem of bitter taste. With the addition of 1 M calcium sulfate, it has low solubility and poor physical properties as well as poor elasticity and bad taste. Addition of 0.1 M calcium lactate has weak physical properties but good sensory properties. From these results, 1 M calcium chloride has the best physical properties, but there is a decisive problem in sensory properties, so 1 M calcium carbonate is most suitable for commercial use.

아프리카 마다가스카르산 로돌라이트 가닛의 보석ㆍ광물학적 연구

김수현(Su Hyun Kim),장윤득(Yun Deuk Jang),김정진(Jeong lin Kim) 한국암석학회 2007 한국암석학회 학술발표회 논문집 Vol.- No.-

의림지 형성과정과 제방축조 연구

김주용(Kim, Ju-yong),양동윤(Yang, Dong-yoon),강상준(Kang, Sang-joon),이상헌(Yi, Sang-heon),남욱현(Nam, Wook-hyun),임재수(Lin, Jae-su),황세호(Hwang, Se-ho),윤현수(Yun, Hyun-su),김진관(Kim, Jin-kwan),홍세선(Hong, Sei-sun),이진영(Lee, J 忠北大學校 中原文化硏究所 2010 중원문화연구 Vol.14 No.-

Eurimji as an ancient water management facility has been known to be built in Iron Age(Sam-Han Age) according to historical document. Eurimji Bank materials are filled on the granitic gneiss and valley fill boulders and rounded water-laid gravels below 307m (asl). Artificial earth materials are gradually dominant at the altitude between 311.2m (asl) and 313.6m (asl). The constructed materials are chracterized by angular to subangular gravels and graded sands in lower part, but gray organic muds with sands are increased upwards. The organic muds up to 314m(asl) are dated ca2,000ysBP, while wood fragments are as old as 1,200yrBP in trhe same interval. This paper deals with the origin of the gray organic muds of Eurimji bank, particularly comparing it with Eurmji lake sediment records, dated as ca 1,900~2,000ysBP, in the interval of 307.5~311.7m(asl) of the borehole ER3-1. As result both Eurimji bank and lake sedimentary materials are the same in mineralogy and chemical composition. This implies that the ancient people excavated gray organic muds from Eurimji lake bottom and use them to construct embankment, made from earths and woods, on the natural lavee or elevated valley mouth due to alluviation. The Eurimji bottom sediments are traced as old as 1920yrBP from borehole ER-3-1, and records are continuous up to 1420ysBP. The lowermost bottom sediments are different in sedimentary matrix from the embankment materials at the same altitudinal level. The latter is typified by the gravel-supported bank materials at the level of 307.5~310.6m in altitude. This implies that a possible construction of Eurimji bank was as old as 1920 years, and bottom sedimentation in the Eurimji had been recorded continuously and stably up to 1200yrBP. However it is supposed that Eurimji bank was mainly constructed at 1200yrBP, when the unified Silla dynasty expanded water reservoirs in the whole country side.