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Leppanen, Jenni,Ng, Kah Wee,Kim, Youl-Ri,Tchanturia, Kate,Treasure, Janet Elsevier 2018 Journal of affective disorders Vol.225 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Heightened threat sensitivity is a transdiagnostic feature in several psychiatric disorders. The neuropeptide oxytocin has been shown to reduce fear related behaviours and facilitated fear extinction in animals. These findings have led to increasing interest to explore the effects of intranasal oxytocin on threat processing in humans.</P> <P><B>Methods</B></P> <P>The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234). The clinical groups included were people with borderline personality disorder (BPD), anorexia nervosa, bulimia nervosa, depression, anxiety, and alcohol dependence disorder. We examined the effects of a single dose of intranasal oxytocin on startle response, attentional responses, and behavioural responses to threat.</P> <P><B>Results</B></P> <P>A single dose of intranasal oxytocin significantly increased the physiological startle response to threat in healthy people with a small effect size. However, oxytocin did not have significant effects on attentional bias towards social or disorder-specific threat, fixation towards threatening stimuli among healthy or clinical populations, or on threat related behavioural approach or avoidance responses.</P> <P><B>Limitations</B></P> <P>No studies investigated the effects of oxytocin on the startle response to threat among clinical populations. Additionally, only one of the reviewed studies had sufficient power to detect at least a moderate effect of oxytocin according to our criterion.</P> <P><B>Discussion</B></P> <P>The synthesis of literature suggest that oxytocin may influence the salience of threatening stimuli among healthy individuals, increasing the startle response to threat. It would be of interest to investigate the effects of oxytocin on the startle response to threat among clinical populations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The review explores the effects of intranasal oxytocin on threat processing. </LI> <LI> Intranasal oxytocin increased startle response to threat in healthy people. </LI> <LI> No significant effects on attentional or approach responses were observed. </LI> </UL> </P>
New Data Processing Features in the Serpent Monte Carlo Code
T. Viitanen,J. Leppanen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
This paper presents two separate nuclear data related features recently implemented in the Serpent Monte Carlo reactor physics burnup calculation code. Probability table sampling in the unresolved resonance region was included to improve the modelling capabilities, especially for fast spectrum systems. The procedure follows standard ENDF reaction laws for ACE format cross section data. The practical implementation of the sampling routine, however, required some additional effort, due to the internal unionized energy grid format and the Woodcock delta-tracking method used by the Serpent code. The second new feature is a built-in Doppler broadening routine that allows the temperatures of point-wise cross sections to be adjusted above their original values.
Rheology in papermaking - from fibre suspension flows to mechanics of solid paper
Hamalainen, Jari,Eskola, Roope,Erkkila, Anna-Leena,Leppanen, Teemu 한국유변학회 2011 Korea-Australia rheology journal Vol.23 No.4
Mathematical modelling of both papermaking fibre suspension flows and solid paper are considered in this paper. The authors own research work has mainly been carried out in the University of Eastern Finland by Paper Physics Group since 2004. The paper also consists of review of other related publications on rheology of paper and fibre suspension flows.
Garcia, Manuel,Vocka, Radim,Tuominen, Riku,Gommlich, Andre,Leppanen, Jaakko,Valtavirta, Ville,Imke, Uwe,Ferraro, Diego,Uffelen, Paul Van,Milisdorfer, Lukas,Sanchez-Espinoza, Victor Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.10
This work deals with the validation of a high-fidelity multiphysics system coupling the Serpent 2 Monte Carlo neutron transport code with SUBCHANFLOW, a subchannel thermalhydraulics code, and TRANSURANUS, a fuel-performance analysis code. The results for a full-core pin-by-pin burnup calculation for the ninth operating cycle of the Temelín II VVER-1000 plant, which starts from a fresh core, are presented and assessed using experimental data. A good agreement is found comparing the critical boron concentration and a set of pin-level neutron flux profiles against measurements. In addition, the calculated axial and radial power distributions match closely the values reported by the core monitoring system. To demonstrate the modeling capabilities of the three-code coupling, pin-level neutronic, thermalhydraulic and thermomechanic results are shown as well. These studies are encompassed in the final phase of the EU Horizon 2020 McSAFE project, during which the Serpent-SUBCHANFLOW-TRANSURANUS system was developed.