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- 저자 : Leng Mui Tan (검색결과 2 건)
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Predictions of Wake and Central Mixing Region of Double Horizontal Axis Tidal Turbine
Stephen Oppong,Wei-Haur Lam,Jianhua Guo,Leng Mui Tan,Zhi Chao Ong,Wah Yen Tey,Yun Fook Lee,Zaini Ujang,Ming Dai,Desmond Robinson,Gerard Hamill 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.7
Predicting the velocity distribution of double horizontal axis tidal turbines (DHATTs) is significant for the effective development of tidal streams. This current research gives an account on double turbine wake theory and flow structure of DHATT connected to single support by using the joint axial momentum theory and computational fluid dynamics (CFD) method. Characteristics of single turbine wake were previously studied with two theoretical equations predicting the initial upstream velocity closer to the turbine, and it’s lateral distributions along the downstream of the turbine. This current works agreed with the previous wake equations, which was used for predicting the velocity region along the downstream of the turbines. Flow field separating the two turbines is complicated in nature due to the indirect disturbance of turbines and no report was found on this central region. The Central region in the downstream flow is initially suppressed due to the blockage effects with a high velocity close to the free stream. Lateral expansion of two turbine wakes penetrated the central region with velocity reduction and followed by the flow recovery further downstream. This work provides more understandings of the wake and its central mixing region for double turbines with a proposed theoretical model.
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Siew Lian Chong,Asral Wirda Ahmad Asnawi,Tze Shin Leong,Jenq Tzong Tan,Kian Boon Law,Siong Leng Hon,Rui Jeat Fann,Sen Mui Tan 대한혈액학회 2021 Blood Research Vol.56 No.3
Background With the emergence of tyrosine kinase inhibitors and the incorporation of stringent measurable residual disease (MRD) monitoring, risk stratification for BCR-ABL1-positive acute lymphoblastic leukemia (ALL) patients has changed significantly. However, whether this monitoring can replace conventional risk factors in determining whether patients need allogeneic stem cell transplantation is still unclear. This study aimed to determine the impact of BCR-ABL1 monitoring on the outcome of patients with BCR-ABL1-positive ALL after allogeneic stem cell transplantation. Methods We retrospectively analyzed the survival outcome of patients with BCR-ABL1-positive ALL based on the quantification of BCR-ABL1 at 3 timepoints: the end of induction (timepoint 1), post-consolidation week 16 (timepoint 2), and the end of treatment for patients who were either transplant-eligible or non-transplant eligible (timepoint 3). Results From 2006 to 2018, a total of 96 patients newly diagnosed with BCR-ABL1-positive ALL were treated with chemotherapy and tyrosine kinase inhibitors. Thirty-eight (41.3%) patients achieved complete remission, and 33 patients underwent allogeneic stem cell transplantation. Our data showed that pre-transplant MRD monitoring by real-time quantitative polymerase chain reaction had the highest correlation with survival in patients with BCR-ABL1-positive ALL, especially for those who underwent allogeneic stem cell transplantation. Conclusion Patients without MRD pre-transplantation had superior survival compared with those who had MRD, and they had excellent long-term outcomes after allogeneic stem cell transplantation.
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