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Enterocytozoon bieneusi Genotypes and Infections in the Horses in Korea
Haeseung Lee,Seung-Hun Lee,Yu-Ran Lee,Ha-Young Kim,Bo-Youn Moon,Jee Eun Han,Man Hee Rhee,Oh-Deog Kwon,Dongmi Kwak 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.6
Enterocytozoon bieneusi is a microsporidian pathogen. Recently, the equestrian population is increasing in Korea. The horse-related zoonotic pathogens, including E. bieneusi, are concerns of public health. A total of 1,200 horse fecal samples were collected from riding centers and breeding farms in Jeju Island and inland areas. Of the fecal samples 15 (1.3%) were PCR positive for E. bieneusi. Interestingly, all positive samples came from Jeju Island. Diarrhea and infection in foals were related. Two genotypes (horse1, horse2) were identified as possible zoonotic groups requiring continuous monitoring.
Occurrence and genetic diversity of <i>Blastocystis</i> in Korean cattle
Lee, Haeseung,Lee, Seung-Hun,Seo, Min-Goo,Kim, Ha-Young,Kim, Jong Wan,Lee, Yu-Ran,Kim, Jong Ho,Kwon, Oh-Deog,Kwak, Dongmi Elsevier 2018 Veterinary parasitology Vol.258 No.-
<P><B>Abstract</B></P> <P> <I>Blastocystis</I> is one of the most commonly detected intestinal protozoan parasites worldwide and has been found in humans and other animals. Therefore, many countries have actively researched this parasite. However, to our knowledge, no study of <I>Blastocystis</I> has been conducted in Korea. Therefore, we conducted a study of the current status of <I>Blastocystis</I> infection in domestic cattle, the various genotypes involved, and its zoonotic potential through a phylogenetic comparison with subtypes found in other studies. The feces of cattle were randomly collected throughout Korea; basic information, including collection date, sex, and cattle type was recorded, and DNA extraction, PCR, and phylogenetic analyses were performed. A total of 1,512 fecal samples were tested. The 101 <I>Blastocystis</I>-positive samples were obtained, yielding an approximate infection rate of 6.7%. Differences in age, cattle type, fecal type, and season were statistically significant between <I>Blastocystis</I>-positive and -negative cattle. In this study, four subtypes of <I>Blastocystis</I> (ST1, ST5, ST10, and ST14) were confirmed by phylogenetic analysis. ST1 and ST5 are potential zoonotic subtypes, therefore the possibility of zoonotic transmission cannot be ignored. Further research and clarification of the infection and transmission patterns of <I>Blastocystis</I> are warranted.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fecal samples from Korean domestic cattle were collected for <I>Blastocystis</I> testing. </LI> <LI> Cattle age, breed, fecal type, and season influenced infection rates. </LI> <LI> Phylogenetic analysis confirmed the presence of subtypes ST1, ST5, ST10, and ST14. </LI> <LI> Zoonotic subtypes were detected, suggesting the risk of zoonotic transmission. </LI> </UL> </P>
Lee, Seung-Hun,Kim, Ha-Young,Lee, Haeseung,Kim, Jong Wan,Lee, Yu-Ran,Chae, Myeong Ju,Oh, Sang-Ik,Kim, Jong Ho,Rhee, Man Hee,Kwon, Oh-Deog,Goo, Youn-Kyoung,Kim, Tae-Hwan,Geraldino, Paul John L,Kwak, Do BMJ Group Group Ltd 2018 The Veterinary record Vol.183 No.16
<P>This study evaluated the prevalence of <I>Eimeria</I> species, particularly <I>E bovis</I>, <I>E zuernii</I> and <I>E auburnensis</I> that are pathogenic to cattle, in faecal samples collected from cattle with diarrhoea reared in the Republic of Korea by using microscopy and PCR. In addition, the prevalence of <I>Eimeria</I> species was analysed according to age, type of cattle, region, season and nature of diarrhoea. Overall, <I>Eimeria</I> species were identified in 279 of the 1261 (22.1 per cent) faecal samples through microscopy, and statistical analysis revealed a lower prevalence in calves aged than three weeks or less and higher prevalence in cattle with haemorrhagic diarrhoea. Of the 279 microscopy-positive samples, <I>E bovis</I>, <I>E zuernii</I> and <I>E auburnensis</I> were identified in 100 (7.9 per cent), 83 (6.6 per cent) and 27 (2.1 per cent) faecal samples, respectively, by using PCR. To the authors' knowledge, this study is the first to apply PCR for epizootiology of bovine coccidiosis.</P>
Systems pharmacology approaches in herbal medicine research: a brief review
Myunggyo Lee,Hyejin Shin,Musun Park,Aeyung Kim,Seongwon Cha,Haeseung Lee 생화학분자생물학회 2022 BMB Reports Vol.55 No.9
Herbal medicine, a multi-component treatment, has been extensivelypracticed for treating various symptoms and diseases. However, its molecular mechanism of action on the humanbody is unknown, which impedes the development and applicationof herbal medicine. To address this, recent studies areincreasingly adopting systems pharmacology, which interpretspharmacological effects of drugs from consequences of the interactionnetworks that drugs might have. Most conventional network-based approaches collect associations of herb-compound,compound-target, and target-disease from individual databases,respectively, and construct an integrated network of herb-compound-target-disease to study the complex mechanisms underlyingherbal treatment. More recently, rapid advances in highthroughputomics technology have led numerous studies to exploringgene expression profiles induced by herbal treatmentsto elicit information on direct associations between herbs andgenes at the genome-wide scale. In this review, we summarizekey databases and computational methods utilized in systemspharmacology for studying herbal medicine. We also highlightrecent studies that identify modes of action or novel indicationsof herbal medicine by harnessing drug-induced transcriptomedata.
마이크로채널 열교환기에서 R-134a의 증발열전달 특성에 관한 실험적 연구
이해승(Haeseung Lee),전동순(Dong-Soon Jeon),김영률(Young-Lyoul Kim),김용찬(Yongchan Kim),김선창(Seon-Chang Kim) 대한기계학회 2010 大韓機械學會論文集B Vol.34 No.2
마이크로채널 열교환기에서 R-134a의 증발열전달 특성에 관하여 실험적 연구를 수행하였다. 마이크로 채널은 금속박판인 SUS304에 포토에칭 공정으로 식각되었으며, 13개의 금속박판은 차례로 적층되어 확산접합 공정을 통하여 접합되었다. 본 연구에서는 R-134a의 증발온도, 질량유속 그리고 물의 입구온도의 변화에 따른 열전달 특성을 대향류 조건에서 실험하였다. 실험결과 R-134a와 물의 입구온도차가 클수록 증발열전달량은 증가하였으며, 증발열전달계수는 0.67 ㎾/㎡ ?℃에서 6.23 ㎾/㎡ ?℃이었다. 아울러 마이크로채널 열교환기에서 R-134a와 물의 열교환에 따른 증발열전달 특성에 영향을 미치는 Reynold수와 무차원 온도비 θ를 도출하여 Nusselt수에 관한 실험적 상관식을 제안하였다. An experimental investigation was carried out to examine the evaporative heat transfer characteristics of R-134a in a micro-channel heat exchanger. The micro-channel heat exchanger used in this study was a sort of plate heat exchanger. Micro-channels were fabricated on the SUS304 plate by the photo-etching process: 13 sheets of plates were stacked and bonded by the diffusion bonding process. The effects of the evaporating temperature, mass flux of R-134a, and inlet temperature of water were examined. As the difference between the inlet temperatures of R-134a and water increased, the heat transfer rate increased. The evaporative heat transfer coefficients obtained in this study range from 0.67 to 6.23 ㎾/㎡ ?℃. The experimental correlation for the Nusselt number as a function of the Reynold number and θ was suggested for the micro-channel heat exchanger.
마이크로채널 열교환기에서 R-134a의 증발열전달 특성에 관한 실험적 연구
이해승(Haeseung Lee),김선창(Seon-Chang Kim),김영률(Young-Lyoul Kim),김용찬(Yongchan Kim) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
Experimental investigations have been carried out to verify the evaporative heat transfer characteristics of R-134a in micro-channel heat exchanger. The micro-channel heat exchanger used in this study is a sort of plate heat exchanger. Micro-channels are fabricated on the SUS304 plate by photo etching process : 13 sheets of plate are stacked and bonded by diffusion bonding process. Effects of evaporating temperature, inlet temperature of water and mass flowrate of R-134a have been examined. The relationship of effectiveness and NTU have been also investigated under the various inlet temperatures of refrigerant and water. As the difference between temperature of inlet refrigerant and that of water increases, the heat transfer rate increases. Evaporative heat transfer coefficients obtained in this study range from 3.30 ㎾/㎡ㆍ℃ to 12.98 ㎾/㎡ㆍ℃.