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Concurrence of ovarian cancer and dermatomyositis: a propensity score analysis
Hongyan Cheng,Lanqing Huo,Dan Wang,Yang Xiang 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6
Objective: To analyze the clinical characteristics, prognosis and parallel clinical course ofovarian cancer (OC) and dermatomyositis (DM). Methods: The medical records of 23 consecutive patients who were diagnosed with OC andDM and were treated at Peking Union Medical College Hospital (PUMCH) between 2002and 2017 were reviewed. Propensity score matching method was used to match controlgroup (OC patients without DM) at a ratio of 1:5. The correlation between OC and DM wasmeasured using the Pearson correlation scatter plot and Pearson's r. Kaplan-Meier survivalanalysis and Cox proportional hazard regression analysis were performed to evaluate theprognostic factors. Results: After matching, 23 patients who have the concurrence of OC and DM (DM group)and 115 patients diagnosed with OC alone (No DM group) were included. The 5-year overallsurvival rates (71.6% vs. 51.8%, p=0.020) and 5-year progression-free survival (30.5% vs. 0%, p=0.018) were poorer in DM group. Correlation between serum cancer antigen 125 (CA125) and creatine kinase (CK) level was observed in 12 patients. The time between OC andDM diagnosis is significant through univariable analysis (p=0.021) but not in multivariableanalysis in patients who have the concurrence of OC and DM. Conclusion: The concurrence of OC and DM as a paraneoplastic syndrome is rare and has apoor prognosis. The risk for patients diagnosed with DM is highest within 3 years before orafter OC diagnosis. A correlation and a parallel clinical course exist between these 2 diseases.