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Po-Wei Lee,Tzu-Yun Wang,Yun-Hsuan Chang,Sheng-Yu Lee,Shiou-Lan Chen,Ze-Cheng Wang,Po See Chen,Chun-Hsien Chu,San-Yuan Huang,Nian-Sheng Tzeng,I Hui Lee,Kao Chin Chen,Yen Kuang Yang,Jau-Shyong Hong,Ru-B 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1
Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors’ Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2+*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1 */*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.
Poster Display : Mast Cells in the Mice Renal Fibrosis Model by Adriamycin
( Dong Wei Yuan ),( Sun Hee Do ),( Hai Jie Yang ),( Il Hwa Hong ),( Young Sook Son ),( Mi Ran Ki ),( Jin Kyu Park ),( Moon Jung Goo ),( Hye Rim Lee ),( Woo Sook Kim ),( Young Ha Lee ),( Suk Hwan Lee ) 한국수의병리학회 2006 학술대회 Vol.10 No.-
( Yan Houy Lee ),( Chong Oui Hong ),( Mi Hyun Nam ),( Ji Hoon Kim ),( Yuan Yuan Ma ),( Young Bu Kim ),( Kwang Won Lee ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Oxidative stress has been postulated to contribute significantly to the accelerated accumulation of advanced glycoxidation endproducts (AGEs) in collagen, which is implicated in the process of skin aging. Effectiveness of Actinidia chinensis, commonly called gold kiwifruit, in counteracting skin aging was investigated. Firstly, primary crude 70% ethanolic extracts of whole A. chinensis, pulp, and rind were screened for their in vitro antioxidant activities and anti-glycation activity by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), Ferric Reducing Antioxidant Power (FRAP) assay, and bovine serum albumin-derived glycation model. Result indicated that rind portion exhibited significantly (p<0.05) high antioxidant activity as well as high phenolic and flavonoid contents compared to those of pulp and whole A. chinensis. Thus, rind was selected for further fractionated with hexane, chloroform, ethyl acetate, and butanol. Among these solvent fractions, A. chinensis rind ethyl acetate (ACRE-E) had the greatest radical-scavenging activity and reducing power, comparable to standard antioxidant, vitamin C. Immunofluorescence staining was used to determine AGEs distribution in glycated collagen matrix. ACRE-E inhibited formation of 67% AGEs. High Performance Liquid Chromatography analysis revealed phenolic compound of ACRE-E as quercetin-3-rhamnoside. High antioxidant and anti-glycation activities of ACRE-E in glycated collagen model indicate its contribution to anti-aging process. A. chinensis rind, previously considered as a byproduct, may have potential as a low-cost raw material for cosmetic and pharmaceutical industries.
Cholangiocarcinoma in a ferret with metastasis to duodenum and mesentery
( Ho Suk Lee ),( Jin Kyu Park ),( Il Hwa Hong ),( Moon Jung Goo ),( Hai Jie Yang ),( Dong Wei Yuan ),( Hye Rim Lee ),( Ok Kyung Hwang ),( Jung Youn Han ),( Kyung Sook Hong ),( Mi Ran Ki ),( Young Sook 한국수의병리학회 2007 학술대회 Vol.11 No.-
Jin Chong-Shik,Kim Mi-Sun,Lee Eun-Hee,Lee Joon-Ho,Lee Jong-Hyun,Moon Su-Jin,Lee Bo-Ra,Jung Kyung-Phil,Li Hong-Yuan Kyung Hee Oriental Medicine Research Center 2002 Oriental pharmacy and experimental medicine Vol.2 No.1
There are over 4,000 different chemicals in cigarette smoke, including nicotine and tar. These compounds influence on lung tissue directly or indirectly. In this study, we have examined whether an aqueous extract of Se-Yeon-Eum (SYE), composed of Oriental medicine that has been known to be effective to symptom by smoking, inhibits nicotine- or cigarette smoke extract (CSE)-induced cytotoxicity in human embryonic lung fibroblast, MRC-9. Assessment of cell viability using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay indicated that SYE inhibited not only nicotine-induced cytotoxicity but also CSE-induced cytotoxicity. These results suggest the possibility that the use of SYE may be useful for improvement of many symptoms by smoking.
Hong, Ming,Geng, Yuanyuan,Liu, Mei,Xu, Yuan,Lee, Yong-Ill,Hao, Jingcheng,Liu, Hong-Guo Elsevier 2015 JOURNAL OF COLLOID AND INTERFACE SCIENCE - Vol.438 No.-
<P><B>Abstract</B></P> <P>An emulsion-directed assembly and adsorption approach has been used to fabricate composite films of polystyrene-b-poly(acryl acid)-b-polystyrene (PS-b-PAA-b-PS) and Eu<SUP>3+</SUP> and La<SUP>3+</SUP> ions at the planar liquid/liquid interface of the polymer DMF/chloroform (1:1, v/v) mixed solution (lower phase) and aqueous solutions of the corresponding salts (upper phase). The lower phase gradually transformed to a water-in-oil (W/O) emulsion via spontaneous emulsification due to the “ouzo effect”. Polymer molecules and the metal ions assembled around emulsion droplets that adsorbed at the planar liquid/liquid interface at last, resulting in formation of composite films. The film morphologies and structures depend on Ln<SUP>3+</SUP> ions: polymer/Eu<SUP>3+</SUP> composite films were foam films composed of microcapsules ranging in size from several hundreds of nanometers to micrometers, while polymer/La<SUP>3+</SUP> composite films were composed of hollow spheres several tens of nanometers in size. Fourier transform infrared (FTIR) spectra revealed that the coordination modes of carboxyl groups to Eu<SUP>3+</SUP> and La<SUP>3+</SUP> were bridging bidentate and ionic, respectively, in the two types of composites. These results indicate that stable microcapsules can be fabricated around droplets for polymer/Eu<SUP>3+</SUP> systems, while microcapsules of polymer/La<SUP>3+</SUP> are unstable. This leads to different film morphologies and structures. Compositions of these films were characterized using energy-dispersive spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS). In addition, foam films of polymer/Eu<SUP>3+</SUP>/2,2′-bipyridine (bpy) were fabricated using this approach, and their photoluminescence properties were investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Composite films of block copolymer/Ln<SUP>3+</SUP> were fabricated at liquid/liquid interfaces. </LI> <LI> Eu<SUP>3+</SUP> and La<SUP>3+</SUP> have great effects on morphologies and microstructures of the films. </LI> <LI> Polymer/Eu<SUP>3+</SUP> and polymer/Eu<SUP>3+</SUP>/bpy films exhibit good luminescent properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yuan, Langtian,Seo, Jin-Soo,Kang, Nam Sook,Keinan, Shahar,Steele, Sarah E.,Michelotti, Gregory A.,Wetsel, William C.,Beratan, David N.,Gong, Young-Dae,Lee, Tong H.,Hong, Jiyong Royal Society of Chemistry 2009 Molecular bioSystems Vol.5 No.9
<P>From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4<I>H</I>-1-benzopyran-4-ones were shown to be isoform-selective PKC-ζ inhibitors.</P> <P>Graphic Abstract</P><P>3-hydroxy-2-(3-hydroxyphenyl)-4<I>H</I>-1-benzopyran-4-ones were shown to be isoform-selective PKC-ζ inhibitors. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b903036k'> </P>
Yuan-Hong Jiang,Ping-Jui Lee,Hann-Chorng Kuo 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.1
Purpose: The aim of this study was to investigate the efficacy of autologous platelet-rich plasma (PRP) in the treatment of stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD) refractory to medical treatment. Methods: Thirty-five patients with SUI due to urodynamically proven ISD were prospectively enrolled. Five milliliters of PRP (2.5–5 times the platelet concentration in peripheral blood) was injected into the external sphincter at 5 sites; all patients received 4 injections at monthly intervals. The primary end-point was the change in SUI severity as assessed by a visual analogue scale (VAS of SUI). The secondary-endpoints were the Global Response Assessment score and changes in urodynamic parameters from baseline to 3 months after treatment. Results: The mean age of patients was 68.7±12 years; the median duration of SUI was 4 years. Five patients had neurogenic SUI, while 30 had nonneurogenic SUI (21 with postprostatectomy incontinence, 6 with previous radical cystectomy, and 3 with other etiologies). Complete dryness was achieved in 7 patients (20.0%) while moderate improvement was observed in 14 (40.0%). The mean VAS of SUI score decreased significantly from 6.57±1.89 to 3.77±2.41 after treatment. The abdominal leak point pressure (ALPP) increased significantly from 98.3±55.8 to 157.3±79.3 cm H2O. There was no increase of ALPP in neurogenic SUI and less increase of ALPP in patients with failed treatment outcomes. No perioperative adverse events or severe complications occurred. Conclusions: Urethral PRP injection is safe and effective in increasing urethral resistance and improving SUI. PRP could be an alternative treatment modality for male and female patients with moderate SUI due to nonneurogenic causes.