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        Amla (Emblica officinalis Gaertn.) Extracts Reduce Oxidative Stress in Streptozotocin-Induced Diabetic Rats

        T.P. Rao,N. Sakaguchi,L.R. Juneja,E. Wada,T. Yokozawa 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3

        The antioxidant properties of amla extracts and their effects on the oxidative stress in streptozotocin-induceddiabetes were examined in rats. Amla in the form of either the commercial enzymatic extract SunAmla (Taiyo Kagaku Co.Ltd., Yokkaichi, Japan) (20 or 40 mg/kg of body weight/day) or a polyphenol-rich fraction of ethyl acetate extract (10 or 20mg/kg of body weight/day) was given orally for 20 days to the streptozotocin-induced diabetic rats. Amla extracts showedstrong free radical scavenging activity. Amla also showed strong inhibition of the production of advanced glycosylated endproducts. The oral administration of amla extracts to the diabetic rats slightly improved body weight gain and also signifi-cantly alleviated various oxidative stress indices of the serum of the diabetic rats. The elevated serum levels of 5-hydrox-ymethylfurfural, which is a glycosylated protein that is an indicator of oxidative stress, were significantly reduced dose-de-pendently in the diabetic rats fed amla. Similarly, the serum level of creatinine, yet another oxidative stress parameter, wasalso reduced. Furthermore, thiobarbituric acid-reactive substances levels were significantly reduced with amla, indicating areduction in lipid peroxidation. In addition, the decreased albumin levels in the diabetic rats were significantly improved withamla. Amla also significantly improved the serum adiponectin levels. These results form the scientific basis supporting theefficacy of amla for relieving the oxidative stress and improving glucose metabolism in diabetes.

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